[Long-term prognosis of manic-depressive psychosis]. / Ob otdalennom prognoze techeniia maniakal'no-depressivnogo psikhoza.

Two groups of patients with a favourable and unfavourable prolonged course of manic-depressive psychosis (161 patients) were compared using computerized selection of the relevant sings and prognostically significant combinations of the signs. Out of the 39 clinical signs characteristic of the initial period of the disease, prognostically significant were the recurrence of psychotic attacks, severity of affective pathology, presence of cyclothymic states and their nature, manifestations of affective pathology (depressive or other) at the beginning of the first phase of psychosis and the severity of somato-vegetative disorders in this pathology. Additionally, the prognostic signs were identified in relation to sex. Combinations of these signs do not determine prognosis in all cases but make it far more probable.

[Intensive therapy of endogenous psychoses]. / Ob intensivnoi terapii éndogennykh psikhozakh.

A reduction of hospital stay facilitates the readaptation of mental patients. One of the conditions for implementing short hospitalization is the intensity of biological treatment: intravenous drip administration of drugs with a rapid increase of doses, rapid neuroleptization, and combination of psychotropic drugs with methods of a general biological influence. A study of 100 patients treated by the routine way demonstrated that intensive therapy significantly reduces the time of hospitalization and promotes remissions. The studies showed that intensive therapy is desirable only in acute psychoses and during the early stages of its development.