RESUMO
Contractions induced by TAME-esterase on rat aorta strips mounted in vitro were significantly inhibited in presence of Vitamin C. The work lends support to the role of ascorbic acid in preventing endothelial dysfunction through release of nitric oxide. It is suggested that conclusions TAME-esterase could be an important biological marker associated with onset of vascular discases such as hypertension.
Assuntos
Aorta Torácica/efeitos dos fármacos , Ácido Ascórbico/farmacologia , Endotélio Vascular/efeitos dos fármacos , Peptídeo Hidrolases/farmacologia , Animais , Aorta Torácica/fisiologia , Endotélio Vascular/fisiologia , Técnicas In Vitro , Contração Muscular/efeitos dos fármacos , Ratos , Ratos Sprague-DawleyRESUMO
Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution of tyrosine kinases during TAME-esterase induced contractions in aorta.
