1.
Org Biomol Chem
; 21(37): 7643-7653, 2023 Sep 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37682240
RESUMO
Herein, we disclosed a sustainable electrochemical approach for site-selective C-H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks. Diversely functionalized disulfides and diselenides possessing EDGs and EWGs were successfully reacted with a variety of indolizines to directly access sulfenylated/selenylated indolizines in 40-96% yields. A mechanistic radical pathway was also validated with control experiments and cyclic voltammogram data.