Assuntos
Tenodese , Tenotomia , Braço , Humanos , Músculo Esquelético/cirurgia , Tendinopatia/cirurgia , Tendões/cirurgiaRESUMO
Comparison of the clastogenic effects of antimony and bismuth used as trioxides, when administered orally by gavaging to laboratory bred male mice, showed that the former was more strongly clastogenic than the latter. Three doses of each chemical (400, 666.67, and 1000 mg/kg body wt), corresponding to 1/50, 1/30, and 1/20 of oral LD50 of antimony trioxide, were fed daily to sets of mice up to 21 d. Animals were sacrificed on day 7, 14, and 21 of the experiment. Chromosomal aberrations and mitotic index were studied from bone marrow cells following a colchicine-air drying Giemsa schedule. The frequencies of chromosomal aberrations induced by both chemicals were directly proportional to the dose used and the duration of exposure, indicating their cumulative effects on the organism. The highest dose of antimony, given for the longest period was, however, lethal. Effects on germ cells, as shown by screening for sperm head abnormalities, were not significant.
Assuntos
Antimônio/toxicidade , Bismuto/toxicidade , Aberrações Cromossômicas , Mutagênicos/toxicidade , Animais , Masculino , CamundongosRESUMO
Antimony trioxide (Sb2O3), in aqueous suspension, was administered by gavaging to mice and monitored for chromosomal aberrations in bone marrow and sperm head abnormalities in germ cells. Acute exposure to the doses followed by observations after 6, 12, 18 and 24 h did not show any clastogenic effects. Chronic exposure daily to different doses for periods up to 21 days induced chromosomal aberrations in bone marrow. The frequencies were dose-dependent to a significant extent but no relationship could be seen with the sex of the animal. The findings indicate the harmful effects of cumulative exposure for prolonged periods to Sb2O3, which is being increasingly used in various industries.
Assuntos
Antimônio/toxicidade , Medula Óssea/patologia , Aberrações Cromossômicas , Mutagênicos/toxicidade , Cabeça do Espermatozoide/efeitos dos fármacos , Administração Oral , Análise de Variância , Animais , Medula Óssea/efeitos dos fármacos , Esquema de Medicação , Feminino , Masculino , Camundongos , Testes de Mutagenicidade , Cabeça do Espermatozoide/ultraestruturaRESUMO
Clastogenic effects of antimony trichloride, used in small industries, were monitored in laboratory bred white Swiss mice in vivo, following oral administration by gavaging, after 6, 12, 18 and 24 h. Chromosomal aberrations were principally breaks and damaged cells observed from bone marrow preparations. The frequencies of chromosomal aberrations were directly related to the dose used and were significantly higher than the control. The chemical did not alter the frequency of dividing cells to any significant level.
