RESUMO
The feeding of a fish extract, prepared by extracting whole fish with 80% ethanol, prevented abdominal, thoracic aorta and coronary atheroma in cholesterol-fed rabbits. Daily fish extract feeding reduced serum cholesterol and LDL-cholesterol levels by 41.8 and 38.0%, respectively. In addition, triglyceride levels were reduced by 52.8%. Hepatic and aortic contents of cholesterol and phospholipids approached normal levels in cholesterol-fed rabbits on the fish extract diet. Fish extract feeding induced a greater fecal excretion of cholesterol. Plaque formation was very little or absent in the aorta of fish-fed rabbits.
Assuntos
Anticolesterolemiantes/uso terapêutico , Colesterol/sangue , Doença da Artéria Coronariana/prevenção & controle , Óleos de Peixe/uso terapêutico , Peixes , Animais , Anticolesterolemiantes/isolamento & purificação , Aorta/metabolismo , Colesterol/metabolismo , Colesterol na Dieta/administração & dosagem , Dieta Aterogênica , Feminino , Óleos de Peixe/isolamento & purificação , Fígado/metabolismo , Masculino , Fosfolipídeos/metabolismo , Coelhos , Triglicerídeos/metabolismoRESUMO
Plumbagin (2-methyl-5-hydroxy, 1:4 naphthoquinone) isolated from the roots of Plumbago zeylanica when administered to hyperlipidaemic rabbits, reduced serum cholesterol and LDL-Chol. by 53 to 86 percent and 61 to 91 percent respectively. It lowered cholesterol/phospholipid ratio by 45.8 percent and elevates the decreased HDL-Chol significantly. Further, Plumbagin treatment prevented the accumulation of cholesterol and triglycerides in liver and aorta and regressed atheromatous plaques of thoracic and abdominal aorta. Plumbagin treated hyperlipidaemic subjects excreted more fecal cholesterol and phospholipids. In conclusion-Plumbagin feeding brings about a definite regression of atheroma and prevents the accumulation of cholesterol and triglycerides in liver and aorta.
