RESUMO
A total of 49 patients with rheumatism running a sluggish course, were examined, as were those with decompensated tonsillitis, systemic lupus erythematosus, and 20 essentially healthy subjects. In inactive rheumatism an increase in the killer activity of lymphocytes and augmentation of amounts of Fc+lymphocytes were revealed, which values were significantly different from those in the other groups. The detected changes in the activity of lymphocytes may serve as differential-diagnostic criteria.
Assuntos
Células Matadoras Naturais/imunologia , Doenças Reumáticas/etiologia , Citotoxicidade Celular Dependente de Anticorpos/imunologia , Doença Crônica , Diagnóstico Diferencial , Humanos , Fragmentos Fc das Imunoglobulinas/sangue , Lúpus Eritematoso Sistêmico/diagnóstico , Doenças Reumáticas/diagnóstico , Tonsilite/diagnósticoRESUMO
The group of 18 men exposed to radiation during amelioration work in the Chernobyl NPP was examined in the course of adaptation to intermittent hypoxia (rebreathing technique during 10 days of three daily 5-7 min sessions with 15 min break). The starting level of ventilatory response to hypoxic stimulus (HVR) did not differ from the one in persons living in non-contaminated areas. This hypoxic training (HT) caused the increase of HVR, activity of NADPH-oxidase and cationic protein content in neutrophils as well as various changes in myeloperoxidase activity. The correlation between respiration reactivity and deviations in neutrophil metabolism under HT was found.
Assuntos
Hipóxia/sangue , Hipóxia/fisiopatologia , Neutrófilos/efeitos da radiação , Exposição Ocupacional/efeitos adversos , Centrais Elétricas , Liberação Nociva de Radioativos , Sistema Respiratório/efeitos da radiação , Adaptação Fisiológica/efeitos da radiação , Adulto , Análise de Variância , Humanos , Masculino , Neutrófilos/enzimologia , Exposição Ocupacional/estatística & dados numéricos , Sistema Respiratório/fisiopatologia , UcrâniaRESUMO
Sixty-five patients with subleukemic myelosis (SLM) during the stage of advanced clinical manifestations were evaluated for parameters characterizing immunologic reactivity. Infectious- inflammatory processes in SLM were found out to develop in the presence of immunity deficiency manifested by the depression of T-and phagocytic link of immunity. Superimposed infection in this pathology promotes further depression of T-link of immunity as well as activation of those cellular parameters characterizing the nonspecific defence.
Assuntos
Infecções Bacterianas/imunologia , Doenças do Sistema Imunitário/imunologia , Tolerância Imunológica , Transtornos Mieloproliferativos/imunologia , Idoso , Infecções Bacterianas/etiologia , Doença Crônica , Feminino , Humanos , Doenças do Sistema Imunitário/etiologia , Imunoglobulinas/sangue , Masculino , Pessoa de Meia-Idade , Transtornos Mieloproliferativos/complicações , Linfócitos T/imunologiaRESUMO
T-cell immunity was assessed in 111 patients with subleukemic myelosis. In such patients with large tumor mass and leukemia exacerbation the amount of immunocompetent cells and their functional activity were reduced more prominently. Association of infection and inflammation promoted aggravation of initial immune deficiency.
Assuntos
Furunculose/imunologia , Leucemia Eritroblástica Aguda/imunologia , Infecções Respiratórias/imunologia , Linfócitos T/imunologia , Adulto , Idoso , Feminino , Furunculose/complicações , Furunculose/patologia , Humanos , Leucemia Eritroblástica Aguda/complicações , Leucemia Eritroblástica Aguda/patologia , Masculino , Pessoa de Meia-Idade , Infecções Respiratórias/complicações , Infecções Respiratórias/patologiaRESUMO
A study was made of cytotoxic activity of lymphocytes and neutrophils in the peripheral blood of 16 patients with advanced stage Kahler's disease, 4 patients in terminal stage, 14 patients with advanced stage chronic lymphoid leukosis, and 6 patients in the terminal stage disease. It has been shown that the level of cytotoxic activity of leucocytes in tumor diseases on the immunity B-system is a criterion for the extent to which the tumor process has been disseminated.
Assuntos
Citotoxicidade Celular Dependente de Anticorpos , Citotoxicidade Imunológica , Leucemia Linfocítica Crônica de Células B/imunologia , Leucócitos/imunologia , Mieloma Múltiplo/imunologia , Humanos , Imunidade Celular , Neutrófilos/imunologia , Estatísticas não ParamétricasRESUMO
An evaluation was done of parameters of neutrophilic link of fagocytosis in 177 patients with chronic myeloleukemia during the course of the illness. All parameters characterizing the phagocyte reaction got reduced compared to normal findings, with the chronic myeloleukemia patients presenting with great size tumors manifesting somewhat more apparent reduction. Pyo-inflammatory processes were found to be most common among those persons presenting with manifest suppression of the phagocytosis function.
Assuntos
Leucemia Mielogênica Crônica BCR-ABL Positiva/complicações , Neutrófilos/imunologia , Fagocitose , Humanos , Imunidade Inata , Síndromes de Imunodeficiência/etiologia , Síndromes de Imunodeficiência/imunologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Contagem de Leucócitos , RecidivaRESUMO
Immunological reactivity and factors of nonspecific body defense were studied in 35 patients with advanced chronic myeloid leukemia (CML). Prior to cytostatic therapy, CML patients have secondary combined immunodeficiency manifesting by inhibition of T-system immunity and phagocytic neutrophil activity. Repeated courses of myelosan chemotherapy aggravate the above immune defects. The adjuvant immunomodulator tactivin corrects cellular immunity and reduces the occurrence of infectious complications 1.77-fold.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Peptídeos/uso terapêutico , Extratos do Timo/uso terapêutico , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The author studied natural cellular cytotoxicity (NCC) and antibody-dependent cytotoxicity (ADC) in lymphocytes from 31 patients with chronic myeloid leukemia (CML) and 37 patients with subleukemic myeloleukemia (SLM) in active clinical stage. The above parameters were found low in both diseases. Cytostatic therapy for CML did not affect NCC, but inhibited ADC. SLM treatment with myelobromol inhibited both cytotoxic responses. Combined therapy with adjuvant tactivin stimulated cytotoxic reactions activity. Tactivin positive effects persisted for two months.
Assuntos
Adjuvantes Imunológicos/farmacologia , Citotoxicidade Imunológica/efeitos dos fármacos , Linfócitos/efeitos dos fármacos , Transtornos Mieloproliferativos/tratamento farmacológico , Peptídeos/farmacologia , Extratos do Timo/farmacologia , Doença Crônica , Humanos , Transtornos Mieloproliferativos/imunologiaRESUMO
The paper provides the results of experimental studies of the effects of heparin given to albino rats with vasorenal hypertension in a dose of 150 U/kg on electrolyte levels in plasma, erythrocytes, cardiac and abdominal aortic tissues, the viscosity coefficient and charge of erythrocytic suspension, transmural difference of abdominal aortic potentials. Heparin has been shown to correct hypertension-induced changes in the transmural difference of abdominal aortic potentials, the charge and viscosity coefficient of erythrocytic suspension, the gradient of sodium, potassium, and calcium in the system of erythrocyte-plasma-abdominal aortic wall.
Assuntos
Aorta Abdominal/efeitos dos fármacos , Viscosidade Sanguínea/efeitos dos fármacos , Eritrócitos/efeitos dos fármacos , Heparina/farmacologia , Hipertensão Renovascular/tratamento farmacológico , Equilíbrio Hidroeletrolítico/efeitos dos fármacos , Animais , Aorta Abdominal/fisiopatologia , Avaliação Pré-Clínica de Medicamentos , Eritrócitos/fisiologia , Heparina/uso terapêutico , Hipertensão Renovascular/sangue , Hipertensão Renovascular/fisiopatologia , Nefrectomia , Ratos , TemperaturaRESUMO
Influence of various patterns of immunocorrective therapy on clinical course of chronic myeloleukemia (CML) was studied. It was shown that combinations of drugs with different pharmacological effects provide more than 5-fold decrease in incidence of infection-related complications and promote rapid recovery from infections during antibacterial treatment.
Assuntos
Imunoterapia/métodos , Leucemia Mielogênica Crônica BCR-ABL Positiva/terapia , Adjuvantes Imunológicos/uso terapêutico , Produtos Biológicos/uso terapêutico , Terapia Combinada , Combinação de Medicamentos , Avaliação de Medicamentos , Quimioterapia Combinada , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/complicações , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Peptídeos/uso terapêutico , Prodigiozan/uso terapêutico , Extratos do Timo/uso terapêutico , Fermento Seco/uso terapêuticoRESUMO
Out of 177 patients with advanced chronic myeloid leukemia infectious complications developed in 23.66%. The chief reason for emergence of bacterial processes in chronic myeloid leukemia is attributed to qualitative and quantitative insufficiency of phagocytizing and immunocompetent cells provoking disturbance of cooperative interaction between lymphocytes and neutrophils.
Assuntos
Infecções Bacterianas/complicações , Leucemia Mielogênica Crônica BCR-ABL Positiva/complicações , HumanosRESUMO
The study of natural killers' (NK) activity was carried out in 114 patients with myelo-proliferative diseases (MPD). Fall of NK-activity was found in all patients. Chronic myeloleukemia was associated with the most considerable decrease of blood leukocytes' cytotoxicity. Patents with gross tumorous mass and exacerbation of leukemic process revealed reduced NK activity as compared to those with low mass of tumor and stable leukemia.
Assuntos
Células Matadoras Naturais/imunologia , Transtornos Mieloproliferativos/etiologia , Doença Crônica , Humanos , Imunidade Celular , Leucemia Mielogênica Crônica BCR-ABL Positiva/etiologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Transtornos Mieloproliferativos/imunologia , Policitemia Vera/etiologia , Policitemia Vera/imunologia , Mielofibrose Primária/etiologia , Mielofibrose Primária/imunologiaAssuntos
Doenças Autoimunes/diagnóstico , Infecções Bacterianas/diagnóstico , Doenças do Tecido Conjuntivo/diagnóstico , Adulto , Citotoxicidade Celular Dependente de Anticorpos , Doenças Autoimunes/etiologia , Infecções Bacterianas/etiologia , Proteínas Sanguíneas/imunologia , Doenças do Tecido Conjuntivo/complicações , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Neutrófilos/imunologiaRESUMO
A study of functional activity of segmentonuclear neutrophil granulocytes of the peripheral blood in 20 patients with subleukemic myelosis (SLM) and 20 patients with polycythemia vera (PV) revealed in the latter an increase of the functional activity of phagocytosis, oxygen-dependent metabolism and enzymatic activity were more pronounced than in SLM. Nonhomogeneity of morphological and cytochemical indices and patients with SLM and IP may be used as supplementary differential diagnostic criterion in SLM and IP.
Assuntos
Transtornos Mieloproliferativos/diagnóstico , Doença Crônica , Diagnóstico Diferencial , Humanos , Transtornos Mieloproliferativos/sangue , Neutrófilos/fisiologia , Policitemia Vera/sangue , Policitemia Vera/diagnóstico , Mielofibrose Primária/sangue , Mielofibrose Primária/diagnósticoAssuntos
Bussulfano/uso terapêutico , Imunidade/efeitos dos fármacos , Síndromes de Imunodeficiência/tratamento farmacológico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Adjuvantes Imunológicos , Linfócitos B/efeitos dos fármacos , Linfócitos B/imunologia , Humanos , Imunidade/imunologia , Imunoglobulinas/análise , Síndromes de Imunodeficiência/etiologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Contagem de Leucócitos/efeitos dos fármacos , Fagocitose/efeitos dos fármacos , Fagocitose/imunologia , Linfócitos T/efeitos dos fármacos , Linfócitos T/imunologiaRESUMO
Concentration of circulating immune complexes (CIC) and cytotoxicity (natural and antibody-dependent) of blood lymphocytes were studied in 52 patients at the developed stage of chronic myeloid leukemia (CML). Elevation of CIC level and reduction of cytotoxicity detectable in all CML patients were most manifest in those with high tumor mass and during exacerbation of the leukemia process. A conclusion has been made that CIC are suppressors of natural and antibody-dependent cytotoxicity of blood lymphocytes in CML patients.
Assuntos
Complexo Antígeno-Anticorpo/imunologia , Citotoxicidade Imunológica/imunologia , Células Matadoras Naturais/imunologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Citotoxicidade Celular Dependente de Anticorpos/imunologia , Humanos , Tolerância Imunológica/imunologiaAssuntos
Produtos Biológicos/farmacologia , Imunidade Inata/efeitos dos fármacos , Leucemia Mieloide Aguda/tratamento farmacológico , Neutrófilos/efeitos dos fármacos , Fagocitose/efeitos dos fármacos , Prodigiozan/farmacologia , Fermento Seco/farmacologia , Formação de Anticorpos/efeitos dos fármacos , Combinação de Medicamentos , Imunidade Inata/imunologia , Leucemia Mieloide Aguda/imunologia , Neutrófilos/imunologiaRESUMO
A study of 32 patients with chronic lympholeucosis (CL) revealed a reduction of the number of phagocytosing neutrophil granulocytes and a reduction of production of humoral mediators by lymphocytes that stimulated the phagocytic function of granulocytes. It is shown that treatment by usually used cytostatic agents did not essentially effect the investigated values. Inclusion of proper-myl in the treatment course of patients with chronic lympholeucosis furthered increase of the number of phagocytosing neutrophil granulocytes and an increased production of humoral mediator stimulating the phagocytic activity of granulocytes.