RESUMO
This study demonstrated that the aqueous extracts of plants employed in Mexican traditional medicine for the treatment of cardiovascular diseases are able to modify the tone of arterial smooth muscle. Agastache mexicana (Kunth) Lint & Epling (Labiatae), Chenopodium murale L. (Chenopodiaceae), Chirantodendron pentadactylon Larreat (Sterculiaceae), Dracocephalum moldavica L. (Labiatae), Psittacanthus calyculatus G. Don (Loranthaceae), Prunus serotina ssp. capuli (Cav. ex Spreng) McVaugh (Rosaceae), and Sechium edule Sw. (Cucurbitaceae) contain secondary metabolites that promote vascular relaxation and display antioxidant activities. As expected, their antioxidant effects showed a significant correlation with the polyphenolics content. However, a lower correlation was found between the antioxidant activity and the maximum vasodilatory effect, suggesting that the vasodilatation elicited by the plant extracts could be only partly attributed to their antioxidant properties. The extract of P. calyculatus, which displayed a maximum vasorelaxant effect that was higher than that of acetylcholine, induced endothelium-dependent vasodilatation. Futhermore, the vasorelaxant response to the P. calyculatus extract was reduced after adding an inhibitor of soluble guanylate cyclase activity, providing evidence that the NO/cGMP pathway is involved. On the other hand, the extracts of Bocconia frutescens L. (Papaveraceae), Magnolia grandiflora L. (Magnoliaceae), and Solanum rostratum Dunal (Solanaceae) induced concentration-dependent contraction of rat aortic rings, suggesting that these plants have potential health benefits for the treatment of ailments such as venous insufficiency. The pharmacological activities of the extracts studied provide scientific support for their ethnomedical use.
Assuntos
Antioxidantes/farmacologia , Doenças Cardiovasculares/tratamento farmacológico , Fitoterapia , Extratos Vegetais/farmacologia , Vasoconstritores/farmacologia , Vasodilatadores/farmacologia , Animais , Aorta/metabolismo , Compostos de Bifenilo/metabolismo , Avaliação Pré-Clínica de Medicamentos , Flavonoides/análise , Técnicas In Vitro , Masculino , Medicina Tradicional , México , Fenóis/análise , Picratos/metabolismo , Extratos Vegetais/química , Plantas Medicinais , Ratos , Ratos WistarRESUMO
Se correlacionaron los hallazgos irideos y la patologia presente y pasada en sujetos aparentemente sanos, en enfermos, y cadaveres; se encontro que 63.69% de la poblacion tiene hallazgos irideos que los iridodiagnosticadores califican como patologicos; el analisis final demostro que solo en 6% de los sujetos aparentemente sanos hay correlacion, que solo en 7% de los enfermos hubo concordancia entre los hallazgos irideos y su patologia y en los cadaveres esto solo sucedio en el 0,25% de los casos. El calculo de Chi cuadrado para los tres grupos demostro que esta coincidencia era debida al azar