RESUMO
La valoración de la respuesta a la terapia es una de las indicaciones más complejas de los estudios de imagen. Valorar la respuesta a la terapia de un paciente incluido en un ensayo clínico usualmente está sujeto a unos criterios de respuesta estandarizados para ese contexto. Sin embargo, en la práctica clínica habitual se realizan muchos estudios en los que la pregunta clínica es si el tratamiento que recibe el paciente está siendo o no efectivo. Responder a esta pregunta representa uno de los mayores retos de los especialistas en imagen, especialmente con la introducción de nuevas modalidades de tratamiento, cuyos efectos directos sobre el tejido tumoral son inicialmente poco conocidos. Tenemos un papel esencial en la introducción de nuevas terapias, valorando sus efectos y sus beneficios en las diferentes situaciones clínicas. El conocimiento de estos efectos ha llevado a desarrollar nuevos criterios de respuesta que, a pesar de ser aplicables únicamente en ensayos clínicos, nos ofrecen información de cómo interpretar los hallazgos en la práctica clínica
Therapy response assessment is one of the most challenging indications of imaging studies. In clinical trial patients is usually measured with standardized response criteria. However, in the clinical practice, many studies are carried out in which the clinical question is whether or not the treatment is being effective. Answering this question is one of the greatest challenges for diagnostic imaging physicians, especially when a new treatment modality is being introduced, whose effects on tumoral lesions are firstly poorly understood. We have an essential role in the introduction of new therapies, assessing their effects and benefits. The knowledge of these effects has led to the development of many response criteria that, despite being applicable only in clinical trials, offer us information on how to interpret the findings in clinical practice
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Imunoterapia , Neoplasias/diagnóstico por imagem , Neoplasias/terapia , Critérios de Avaliação de Resposta em Tumores Sólidos , Progressão da Doença , Imunoterapia/efeitos adversos , Imunoterapia Adotiva , Neoplasias/metabolismo , Neoplasias/patologia , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada por Raios XRESUMO
Therapy response assessment is one of the most challenging indications of imaging studies. In clinical trial patients is usually measured with standardized response criteria. However, in the clinical practice, many studies are carried out in which the clinical question is whether or not the treatment is being effective. Answering this question is one of the greatest challenges for diagnostic imaging physicians, especially when a new treatment modality is being introduced, whose effects on tumoral lesions are firstly poorly understood. We have an essential role in the introduction of new therapies, assessing their effects and benefits. The knowledge of these effects has led to the development of many response criteria that, despite being applicable only in clinical trials, offer us information on how to interpret the findings in clinical practice.