Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Med Sci (Basel) ; 7(2)2019 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-30696099

RESUMO

The double burden of malnutrition (DBM) and anaemia is a growing concern in developing countries. Using the cross-sectional Bangladesh Demographic Health Survey, 2011, 5763 mother⁻child pairs were examined. In households where the mother was overweight, 24.5% of children were stunted, 19.8% underweight, 9.3% wasted, and 51.7% anaemic. Significant regional differences were found in DBM and anaemia as well as drinking water source, while DBM alone was more common in more well-off households (based on wealth index) and where the father was employed in skilled or service occupations. More policy and awareness programmes are needed to address the coexistence of child undernutrition and maternal overweight/obesity and anaemia in the same household.

2.
Nutrients ; 8(3): 148, 2016 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-26959060

RESUMO

Anemia and micronutrient deficiencies are widespread in sub-Saharan Africa, but the impact of food fortification is still debated. The objective of this study was to estimate the iron and vitamin A status of preschool children (PSC) and women of reproductive age (WRA) in households consuming fortified oil and wheat flour. The survey was cross-sectional in a rural and an urban area. Data on demographics, socioeconomic status, and fortified foods were collected at households. Hemoglobin (Hb), retinol binding protein (RBP), ferritin, soluble transferrin receptors (sTfR), subclinical inflammation, and Plasmodium spp. infection data were collected. In PSC, vitamin A deficiency (VAD) was prevalent, but for each 1 mg retinol equivalents (RE)/kg of oil consumed, RBP increased by 0.37 µmol/L (p = 0.03). In WRA, there was no significant VAD in the population (0.7%). Anemia was found in 92.2% of rural and 56.3% of urban PSC (p < 0.001). PSC with access to adequately fortified flour had Hb concentrations 15.7 g/L higher than those who did not (p < 0.001). Hb levels increased by +0.238 g/L per mg/kg increase in iron fortification levels (p < 0.001). The national program fortifying vegetable oil with vitamin A and wheat flour with iron and folic acid may have contributed to improved micronutrient status of PSC from two areas in Côte d'Ivoire.


Assuntos
Anemia Ferropriva/prevenção & controle , Doenças Endêmicas , Farinha , Ácido Fólico/administração & dosagem , Alimentos Fortificados , Ferro/administração & dosagem , Malária/dietoterapia , Óleos de Plantas , Deficiência de Vitamina A/prevenção & controle , Vitamina A/administração & dosagem , Adolescente , Adulto , Fatores Etários , Anemia Ferropriva/sangue , Anemia Ferropriva/epidemiologia , Anemia Ferropriva/parasitologia , Biomarcadores/sangue , Pré-Escolar , Côte d'Ivoire/epidemiologia , Estudos Transversais , Feminino , Ácido Fólico/sangue , Inquéritos Epidemiológicos , Humanos , Lactente , Ferro/sangue , Malária/sangue , Malária/epidemiologia , Malária/parasitologia , Masculino , Pessoa de Meia-Idade , Avaliação Nutricional , Estado Nutricional , Valor Nutritivo , Óleo de Palmeira , Gravidez , Prevalência , Avaliação de Programas e Projetos de Saúde , Saúde da População Rural , Fatores Socioeconômicos , Saúde da População Urbana , Vitamina A/sangue , Deficiência de Vitamina A/sangue , Deficiência de Vitamina A/epidemiologia , Deficiência de Vitamina A/parasitologia , Adulto Jovem
3.
J Neurosci ; 24(24): 5537-48, 2004 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-15201326

RESUMO

Mutant mice with a hypersensitive serotonin (5-HT)3A receptor were generated through targeted exon replacement. A valine to serine mutation (V13'S) in the channel-lining M2 domain of the 5-HT3A receptor subunit rendered the 5-HT3 receptor 70-fold more sensitive to serotonin and produced constitutive activity when combined with the 5-HT3B subunit. Mice homozygous for the mutant allele (5-HT3Avs/vs) had decreased levels of 5-HT3A mRNA. Measurements on sympathetic ganglion cells in these mice showed that whole-cell serotonin responses were reduced, and that the remaining 5-HT3 receptors were hypersensitive. Male 5-HT3Avs/vs mice died at 2-3 months of age, and heterozygous (5-HT3Avs/+) males and homozygous mutant females died at 4-6 months of age from an obstructive uropathy. Both male and female 5-HT3A mutant mice had urinary bladder mucosal and smooth muscle hyperplasia and hypertrophy, whereas male mutant mice had additional prostatic smooth muscle and urethral hyperplasia. 5-HT3A mutant mice had marked voiding dysfunction characterized by a loss of micturition contractions with overflow incontinence. Detrusor strips from 5-HT3Avs/vs mice failed to contract to neurogenic stimulation, despite overall normal responses to a cholinergic agonist, suggestive of altered neuronal signaling in mutant mouse bladders. Consistent with this hypothesis, decreased nerve fiber immunoreactivity was observed in the urinary bladders of 5-HT3Avs/vs compared with 5-HT3A wild-type (5-HT3A+/+) mice. These data suggest that persistent activation of the hypersensitive and constitutively active 5-HT3A receptor in vivo may lead to excitotoxic neuronal cell death and functional changes in the urinary bladder, resulting in bladder hyperdistension, urinary retention, and overflow incontinence.


Assuntos
Receptores 5-HT3 de Serotonina/biossíntese , Receptores 5-HT3 de Serotonina/genética , Obstrução do Colo da Bexiga Urinária/patologia , Obstrução do Colo da Bexiga Urinária/fisiopatologia , Animais , Animais Recém-Nascidos , Feminino , Humanos , Técnicas In Vitro , Contração Isométrica , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Mutantes , Músculo Liso/fisiopatologia , Fibras Nervosas/patologia , Oócitos/fisiologia , Técnicas de Patch-Clamp , Mutação Puntual , Uretra/fisiopatologia , Bexiga Urinária/inervação , Bexiga Urinária/patologia , Bexiga Urinária/fisiopatologia , Obstrução do Colo da Bexiga Urinária/mortalidade , Urodinâmica , Xenopus
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...