1.
Bioorg Med Chem Lett
; 10(20): 2255-7, 2000 Oct 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11055332
RESUMO
Structure activity studies on [4-(phenylsulfonyl)phenyl]methylpiperazine led to the discovery of 4-cyclohexyl-alpha-[4-[[4-methoxyphenyl(S)-sufinyl]phenyl]-1-pi perazineacetonitrile, 1, an M2 selective muscarinic antagonist. Affinity at the cloned human M2 receptor was 2.7 nM; the M1/M2 selectivity is 40-fold.