[2-Arylidene 3,4-dihydro-1 (2H)-naphthalenones with potential platelet anti-aggregating activity: synthesis and structural and pharmacologic study]. / Arylidène-2 dihydro-3,4 (2H) naphtalénones-1 à visée antiagrégante plaquettaire: synthèse, étude pharmacologique et structurale.

New 3,4-dihydro-2-arylidene-1-(2H)-naphthalenones derivatives were synthesized and their inhibitory effects in vitro on the arachidonic acid-induced platelet aggregation were evaluated. The 3,4-dihydro-2-[(2,5-dimethoxyphenyl)methylene]-1-(2H)-naphthalenone++ + exhibits the most potent antiaggregating activity; compared with aspirin this compound is three times more active. Its crystal structure has been determined.