Disclosure of Type 1 diabetes at work among Finnish workers.

AIMS: To determine which self-management factors and psychosocial work factors were associated with disclosing diabetes to colleagues, line managers and occupational health personnel among workers with Type 1 diabetes. METHODS: A total of 767 working-aged respondents with Type 1 diabetes completed a Finnish cross-sectional survey named 'People with Type 1 Diabetes in Worklife'. Factor analysis was carried out, followed by logistic regressions to estimate the associations between self-management factors, psychosocial work factors and the likelihood of disclosure separately to colleagues, line managers and occupational health personnel. The models were adjusted for sociodemographic, diabetes-related and work-related variables. RESULTS: A total of 52% of the respondents had disclosed their diabetes to their colleagues, 45% to occupational health personnel and 28% to their line manager. Receiving social support and having good psychosocial work ability were significantly associated with disclosure to colleagues, line managers and occupational health personnel. Relations at work were associated with disclosure to colleagues and the line manager. Furthermore, opportunity to self-manage diabetes at work was associated with disclosure to colleagues. CONCLUSIONS: Line managers and colleagues have a remarkable role to play in providing workplace support to workers with Type 1 diabetes. Disclosure of Type 1 diabetes should be encouraged as line managers can provide workers with the right support, implement work adaptations and facilitate job retention. As only half of respondents disclosed their Type 1 diabetes at work, further research is required into the reasons for and consequences of not disclosing a diagnosis.

Work ability among Finnish workers with type 1 diabetes.

BACKGROUND: Work ability represents the balance between individual resources, health status and job demands. As far as we are aware, these issues have not been examined in working people with type 1 diabetes (T1D). AIMS: To examine how work-related and diabetes-related factors are associated with work ability among male and female workers. METHODS: Questionnaires were mailed to a random sample of 2500 people with T1D from the Medication Reimbursement Register of The Social Insurance Institution of Finland. The associations of the predictors of poor work ability were examined in a logistic regression analysis. RESULTS: The final sample comprised 767 working people aged 18-64 with T1D; overall response rate 49%. One in every three working men and women with T1D had poor work ability. High job demands and low job control were associated with poor work ability in both genders. Physical work and low worktime control were significantly associated with poor work ability in men but not in women with T1D. A self-reported high value of glycosylated haemoglobin was the only diabetes-related variable associated with poor work ability in both men and women. CONCLUSIONS: Work-related factors and poor glycaemic control were associated with poor work ability in individuals with T1D. Thus, job control and worktime control should be taken into account in supporting the work ability of workers with T1D.

First stretching overtone of BiH3: an extreme local-mode case for XH3-type molecule?

The first stretching overtone region of short-lived, formerly inaccessible BiH3 near 3405 cm(-1) has been measured by Fourier-transform infrared spectroscopy with a resolution of 0.0066 cm(-1). Only the 2nu1(A1)/nu1+nu3(E) band system has been observed. Rotational analysis, with transitions reaching J'max=14, has revealed almost perfect local-mode behavior for the upper states denoted as (200A1/E) in the local-mode notation. Ratios of vibration-rotation interaction parameters q(eff)/alpha(eff)(BB) and r(eff)/alpha(eff)(BC), and the appropriate rotational constant differences, are in good agreement with theoretical local-mode limit values. A simple stretching vibrational model reproduces the observed vibrational term values well, and the potential parameters obtained are close to true values.

Narratives of recovery from addictive behaviours.

AIMS: The purpose of this study was to look for the ways in which people who have recovered from various addictions understand and present their change process. MATERIALS: The research material consisted of 51 autobiographical stories of people who had been able to quit their addiction to alcohol, multiple drugs, binge eating, smoking, sex and gambling. METHODS: The basic logic of each narrative was first defined. The narratives were then categorized according to what they presented as the key to recovery. Composite stories were then constructed and analysed with regard to their emotional, causal, moral and ethical meanings. FINDINGS: The analysis revealed five different story types among these self-narratives: the AA story, the growth story, the co-dependence story, the love story and the mastery story. All of them helped to make the addiction and recovery understandable, they released the protagonist from guilt and had a happy ending by which the values of the story were realized. Each story type was told predominantly by representatives of a particular gender and addiction. CONCLUSIONS: As there are several ways out of addictive behaviours there are also several ways to construe the change. People who try to quit addictive behaviours could be encouraged to make full use of the cultural stock of stories in creating an account that fits their own experience of defeating their particular addiction.

Chronic treatment with BRL 35135 potentiates the action of insulin on lipid metabolism.

The effects of a beta 3-adrenoceptor agonist on insulin-induced changes in lipid metabolism were studied in obese male Zucker (fa/fa) rats during euglycaemic clamp. Rats were treated with BRL 35135 (R*, R*-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl)-ethyl-amino]-propyl] phenoxyacetate hydrobromide) (0.5 mg/kg per day in drinking water) for three weeks before an euglycaemic hyperinsulinaemic clamp was performed. Insulin infusion lowered serum non-esterified fatty acids and plasma glycerol more efficiently in BRL 35135-treated than in control rats although plasma insulin remained significantly lower in the BRL 35135-treated than in the control rats during the clamp. In conclusion, chronic treatment with BRL 35135 potentiates the effect of insulin on lipid metabolism.

Sex differences in coping and depression among young adults.

The main purpose of the study was to evaluate the notion that the association between sex and depression is partly mediated by differences in coping styles. The study is based on questionnaire data from 890 female and 766 male Finnish 22-year-old young adults. Of the 12 ways of coping presented, self-blame, venting anger on others, seeking comfort in sweets and drinking beer were positively, and the others negatively, associated with depression; these were called dysfunctional and functional ways of coping, respectively. Women resorted much more often than men to dysfunctional ways of coping, except drinking. They also scored lower on personal resilience and showed more depressive symptoms. The sex difference in depressiveness was eliminated when dysfunctional coping was taken into account.

Effects of metformin treatment on glucose transporter proteins in subcellular fractions of skeletal muscle in (fa/fa) Zucker rats.

1. The present study was designed to clarify the cellular mechanism through which the antihyperglycaemic drug, metformin, exerts its effects. For this purpose the contents of glucose transporter protein isoforms GLUT1 and GLUT4 were measured in plasma membrane and intracellular membrane fractions of skeletal muscle obtained from genetically obese, insulin-resistant Zucker rats. 2. Hindlimb muscles were dissected from metformin-treated (300 mg kg-1 day-1, p.o., for 12 days) and control rats in basal treatment state, and after acute stimulation with insulin (22 u kg-1, i.p.). Since metformin treatment reduces food intake, we also used a pair-fed control group to investigate the effects of altered insulinaemia per se. Glucose transporter levels were analysed by Western blot and slot blot-techniques. In addition, 2-deoxy-[14C]-glucose uptake in isolated muscle strips was evaluated. 3. No changes were noted in the contents of GLUT1 proteins in any of the subcellular fractions after metformin treatment. The contents of GLUT4 in subcellular fractions were not altered in the basal treatment state. After acute insulin exposure the content of GLUT4 in the intracellular membrane fraction declined significantly in the metformin-treated group, while no significant effect was seen in the plasma membrane fraction. In agreement with these results, metformin treatment did not alter 2-deoxyglucose uptake into isolated muscle strips. 4. In conclusion, the present study does not support the concept that metformin would enhance translocation of glucose transporter proteins from the intracellular compartment to the plasma membrane in skeletal muscle in vivo.

Psychosocial factors at work in relation to back and limb disorders.

OBJECTIVES: This study was a 10-year follow-up of the associations between work content, work control, social relationships at work, mental overstrain, physical work load, and musculoskeletal morbidity in the neck, shoulder and upper limb region, the low back, and the lower limbs among workers in the metal industry. METHODS: A sample of 902 blue- and white-collar employees were studied. Measurements were made twice at the a 10-year interval by questionnaire and clinical examination. RESULTS: At the beginning of the study, mental overstrain showed several associations with both the symptoms and the findings. The other psychosocial factors were the most consistently associated with the symptoms in the region of the neck, shoulder, and upper limbs and also in the lower-limb region among the middle-aged men. Prospectively, the social relations and the work content scores predicted the change in several morbidity scores. The associations were independent of physical work load. CONCLUSIONS: Work-related psychosocial factors were associated with, and predicted, the change in the occurrence of musculoskeletal disorders when age, gender, social class, and physical work load were controlled for.

Potentiation of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise.

UNLABELLED: 1. The effects of chronic treatments with a selective beta 3-adrenoceptor agonist and a selective alpha 2-adrenoceptor antagonist and their interactions with physical exercise training were studied in experimental obesity. 2. BRL 35135 (beta 3-agonist, 0.5 mg kg-1 day-1 p.o.), atipamezole (alpha 2-antagonist, 4.0 mg kg-1 day-1 p.o.) and placebo were given to genetically obese male Zucker rats. Half of the rats were kept sedentary whereas the other half were subjected to moderate treadmill exercise training. Body weight gain, cumulative food intake, the neuropeptide Y content of the hypothalamic paraventricular nucleus, brown adipose tissue thermogenic activity (measured as GDP binding), plasma insulin and glucose levels were measured after 3 weeks' treatment and exercise. 3. Treatment with BRL 35135 reduced weight gain by 19%, increased brown adipose tissue thermogenic activity 45-fold and reduced plasma insulin by 50%. Atipamezole slightly increased food intake and neuropeptide Y content in the paraventricular hypothalamic nucleus but had no effect on the other measured parameters. Exercise alone had no effect on weight gain, food intake or thermogenic activity, whereas it reduced plasma insulin and glucose levels. 4. The effect of BRL 35135 on weight gain and thermogenic activity was significantly potentiated by exercise; the reduction in weight gain was 56% in comparison with 19% in sedentary animals. Food intake was significantly reduced in the BRL 35135-treated-exercise-trained animals, although neither beta 3-agonist nor exercise alone affected it. 5. Based on the present results in genetically obese Zucker rats, combination of 03-agonist treatment with a moderate physical training may offer a new feasible approach to the therapy of obesity.- KEYWORDS: BRL 35135; atipamezole; P3-adrenoceptor agonism; M2-adrenoceptor antagonism; brown adipose tissue; thermogenesis;genetic obesity; Zucker rat; exercise; neuropeptide Y

Social support, life events and psychosomatic symptoms among 14-16-year-old adolescents.

The role of family, friends and confidants in mediating the impact of adverse life events on psychosomatic symptoms in mid-adolescence was studied. School children (n = 2013) completed questionnaires in class on three occasions during 17 months. Data about social support and life events for 12 months were gathered retrospectively in the final questionnaire. The differences in symptoms by life events and social support were already present at the beginning of the study. Those adolescents who had experienced adverse life events and reported a poor relationship with one or both parents had the highest levels of symptoms and the greatest increase in symptoms during the follow-up. Lack of friends was also associated with psychosomatic symptoms, especially among those who had experienced adverse life events. The results suggest that adolescents who lack parental or peer support are at risk for psychosomatic symptoms in general, and especially in the face of stressful life events.

The effects of intensity, frequency, static load, and shore hardness on different parameters in vibration sensitivity measurements.

The effects of shore hardness, static load, frequency, and intensity of vibration on the amplitude and dynamic force effects of vibration were studied in conditions corresponding to those occurring in vibrotactile sensitivity measurements. The measurements were performed on three silicon plates of known shore hardness. The results indicated that the effect of differences in elasticity on the vibration amplitudes was evident at lower frequencies up to about 200 Hz whereas at higher frequencies the amplitudes remained at the same level, regardless of elasticity. On dynamic force the effect of elasticity was observed at all frequencies studied (50-500 Hz). The static load of the contractor had only minimal effects on amplitudes and dynamic force levels at the loads used (1-3N).

Effects of job change on job satisfaction and mental strain.

The effect of improved work conditions on symptoms of mental strain was examined in a longitudinal study of metal industry employees. The aim was to study the changes in work conditions, job satisfaction, and indices of mental strain among the employees who were promoted or who changed employer in comparison to those who had stayed in the same job during the five-year follow-up period (matched groups, N 136). During the study period, work content and physical work environment had significantly improved in the job-change group compared to the reference group. Job dissatisfaction, life dissatisfaction, and stress symptoms had decreased significantly in the job-change group. The most powerful predictors of changes in job stress or general mental strain were changes in work content and changes in the quality of the physical work environment. However, the multiple correlations obtained in the regression analyses were not high.

Life events or life processes as determinants of mental strain? A 5-year follow-up study.

In a study among Finnish metal industry employees (n = 748) mental strain was measured at the beginning and at the end of a 5-year follow-up. Life event data for the follow-up period were gathered retrospectively through a questionnaire and a later interview. Mental strain was substantially higher among blue-collar than white-collar workers. In contrast, no differences in the occurrence or in the rating of life events was observed between these groups. Self-rated undesirable events were associated with high levels and desirable events with low levels of mental strain. Similar associations were observed in three objectively defined live events, viz. divorce, promotion in the job and change in housing conditions. Life events were, however, also related with the mental strain measured prior to the life events. Both the self-rated and objectively defined desirable events had usually a favourable impact on mental well-being, whereas undesirable events in most cases slightly increased mental strain. The differences in mental strain between occupational status groups seem to be caused by differences in the life processes rather than life events. Furthermore, many life events, e.g. divorce, are actually only discrete moments in long-lasting processes, which have an impact on mental well-being. And last, desirable life events can be seen rather as a preventive than a risk factor of mental strain.

Time-resolved fluoroimmunoassay of human choriogonadotropin.

We describe time-resolved fluoroimmunoassay for human choriogonadotropin involving monoclonal antibodies directed against the beta- and alpha-subunits. The latter antibody was labeled with europium, which was measured by counting for 1 s after the immunoreaction was completed. In the solid-phase sandwich assay, both a one-step and two-step procedure were used; the respective measuring ranges were 0.7-135 and 0.7-350 int. units/L, the latter covering a 500-fold dynamic range. The CV within the assay range was between 4 and 8%, depending on the dose. Cross reactivity with lutropin in the one- and two-step procedures was 1.6% and 1.0%, respectively.