1.
Medchemcomm
; 9(12): 2068-2071, 2018 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30746064
RESUMO
We report on the synthesis, in vitro and in vivo biological evaluations of a dimeric ß-glucuronidase-responsive albumin-binding prodrug designed for the double release of MMAE upon a single enzymatic activation step. This prodrug produced a significant antitumour activity in mice bearing subcutaneous LS174T colorectal adenocarcinoma xenografts without inducing side effects.