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1.
Pest Manag Sci ; 75(11): 3113-3121, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31317630

RESUMO

BACKGROUND: Strigolactones (SLs) have a vast number of ecological implications because of the broad spectrum of their biological activities. Unfortunately, the limited availability of SLs restricts their applicability for the benefit of humanity and renders synthesis the only option for their production. However, the structural complexity of SLs impedes their economical synthesis, which is unfeasible on a large scale. Synthesis of SL analogues and mimics with a simpler structure, but with retention of bioactivity, is the solution to this problem. RESULTS: Here, we present eight new hybrid-type SL analogues derived from auxin, synthesized via coupling of auxin ester [ethyl 2-(1H-indol-3-yl)acetate] and of ethyl 2-phenylacetate with four D-rings (mono-, two di- and trimethylated). The new hybrid-type SL analogues were bioassayed to assess the germination activity of seeds of the parasitic weeds Striga hermonthica, Orobanche minor and Phelipanche ramosa using the classical method of counting germinated seeds and a colorimetric method. The bioassays revealed that analogues with a natural monomethylated D-ring had appreciable to good activity towards the three species and were the most active derivatives. By contrast, derivatives with the trimethylated D-ring showed no activity. The dimethylated derivatives (2,4-dimethyl and 3,4-dimethyl) were slightly active, especially towards P. ramosa. CONCLUSIONS: New hybrid-type analogues derived from auxins have been prepared. These analogues may be attractive as potential suicidal germination agents for parasitic weed control because of their ease of preparation and relevant bioactivity. © 2019 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.


Assuntos
Germinação/efeitos dos fármacos , Ácidos Indolacéticos/química , Lactonas/síntese química , Orobanchaceae/efeitos dos fármacos , Plantas Daninhas/efeitos dos fármacos , Controle de Plantas Daninhas/métodos , Orobanchaceae/fisiologia , Orobanche/efeitos dos fármacos , Orobanche/fisiologia , Plantas Daninhas/fisiologia , Sementes/efeitos dos fármacos , Sementes/fisiologia , Striga/efeitos dos fármacos , Striga/fisiologia
3.
Pest Manag Sci ; 75(7): 2049-2056, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30632264

RESUMO

BACKGROUND: Strigolactones are a unique class of plant metabolites which serve as a rhizosphere signal for parasitic plants and evocate their seed germination. The expansion of these parasitic weeds in the food crop fields urgently calls for their increased control and depletion. Simple strigolactone analogues able to stimulate seed germination of these parasitic plants may represent an efficient control measure through the induction of suicidal germination. RESULTS: Triazolide-type strigolactone mimics were easily synthesized in three steps from commercially available materials. These derivatives induced effectively seed germination of Phelipanche ramosa with EC50 as low as 5.2 × 10-10 M. These mimics did not induce seed germination of Striga hermonthica even at high concentration (≥1 × 10-5 M). CONCLUSIONS: Simple and stable strigolactone mimics with selective activity against Phelipanche ramosa were synthesized. © 2019 Society of Chemical Industry.


Assuntos
Germinação/efeitos dos fármacos , Lactonas/síntese química , Lactonas/farmacologia , Orobanchaceae/efeitos dos fármacos , Herbicidas/síntese química , Herbicidas/farmacologia , Plantas Daninhas/efeitos dos fármacos , Sementes/efeitos dos fármacos
4.
N Biotechnol ; 48: 76-82, 2019 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-30077756

RESUMO

Strigolactones (SLs) constitute a new class of plant hormones of increasing importance in plant science. The structure of natural SLs is too complex for ready access by synthesis. Therefore, much attention is being given to design of SL analogues and mimics with a simpler structure but with retention of bioactivity. Here new hybrid type SL mimics have been designed derived from auxins, the common plant growth regulators. Auxins were simply coupled with the butenolide D-ring using bromo (or chloro) butenolide. D-rings having an extra methyl group at the vicinal C-3' carbon atom, or at the C-2' carbon atom, or at both have also been studied. The new hybrid type SL mimics were bioassayed for germination activity of seeds of the parasitic weeds S. hermonthica, O. minor and P. ramosa using the classical method of counting germinated seeds and a colorimetric method. For comparison SL mimics derived from phenyl acetic acid were also investigated. The bioassays revealed that mimics with a normal D-ring had appreciable to good activity, those with an extra methyl group at C-2' were also appreciably active, whereas those with a methyl group in the vicinal C-3' position were inactive (S. hermonthica) or only slightly active. The new hybrid type mimics may be attractive as potential suicidal germination agents in agronomic applications.


Assuntos
Materiais Biomiméticos/química , Ácidos Indolacéticos/química , Lactonas/química , Reguladores de Crescimento de Plantas/química , Materiais Biomiméticos/síntese química , Materiais Biomiméticos/farmacologia , Desenho de Fármacos , Estabilidade de Medicamentos , Germinação/efeitos dos fármacos , Ácidos Indolacéticos/síntese química , Ácidos Indolacéticos/farmacologia , Lactonas/síntese química , Lactonas/farmacologia , Estrutura Molecular , Reguladores de Crescimento de Plantas/síntese química , Reguladores de Crescimento de Plantas/farmacologia , Plantas Daninhas/efeitos dos fármacos , Plantas Daninhas/crescimento & desenvolvimento
5.
J Nat Prod ; 81(11): 2321-2328, 2018 11 26.
Artigo em Inglês | MEDLINE | ID: mdl-30362743

RESUMO

Strigolactones are a particular class of plant metabolites with diverse biological functions starting from the stimulation of parasitic seed germination to phytohormonal activity. The expansion of parasitic weeds in the fields of developing countries is threatening the food supply and calls for simple procedures to combat these weeds. Strigolactone analogues represent a promising approach for such control through suicidal germination, i.e., parasitic seed germination without the presence of the host causing parasite death. In the present work, the synthesis of resorcinol-type strigolactone mimics related to debranones is reported. These compounds were highly stable even at alkaline pH levels and able to induce seed germination of parasitic plants Striga hermonthica and Phelipanche ramosa at low concentrations, EC50 ≈ 2 × 10-7 M ( Striga) and EC50 ≈ 2 × 10-9 M ( Phelipanche). On the other hand, the mimics had no significant effect on root architecture of Arabidopsis plants, suggesting a selective activity for parasitic seed germination, making them a primary target as suicidal germinators.


Assuntos
Germinação/efeitos dos fármacos , Lactonas/farmacologia , Orobanchaceae/fisiologia , Resorcinóis/química , Lactonas/química , Orobanchaceae/embriologia , Reguladores de Crescimento de Plantas/farmacologia , Sementes/efeitos dos fármacos , Sementes/fisiologia , Striga/embriologia , Striga/fisiologia
6.
Front Plant Sci ; 9: 1327, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30271419

RESUMO

Environmental stresses have a significant effect on agricultural crop productivity worldwide. Exposure of seeds to abiotic stresses, such as salinity among others, results in lower seed viability, reduced germination, and poor seedling establishment. Alternative agronomic practices, e.g., the use of plant biostimulants, have attracted considerable interest from the scientific community and commercial enterprises. Biostimulants, i.e., products of biological origin (including bacteria, fungi, seaweeds, higher plants, or animals) have significant potential for (i) improving physiological processes in plants and (ii) stimulating germination, growth and stress tolerance. However, biostimulants are diverse, and can range from single compounds to complex matrices with different groups of bioactive components that have only been partly characterized. Due to the complex mixtures of biologically active compounds present in biostimulants, efficient methods for characterizing their potential mode of action are needed. In this study, we report the development of a novel complex approach to biological activity testing, based on multi-trait high-throughput screening (MTHTS) of Arabidopsis characteristics. These include the in vitro germination rate, early seedling establishment capacity, growth capacity under stress and stress response. The method is suitable for identifying new biostimulants and characterizing their mode of action. Representatives of compatible solutes such as amino acids and polyamines known to be present in many of the biostimulant irrespective of their origin, i.e., well-established biostimulants that enhance stress tolerance and crop productivity, were used for the assay optimization and validation. The selected compounds were applied through seed priming over a broad concentration range and the effect was investigated simultaneously under control, moderate stress and severe salt stress conditions. The new MTHTS approach represents a powerful tool in the field of biostimulant research and development and offers direct classification of the biostimulants mode of action into three categories: (1) plant growth promotors/inhibitors, (2) stress alleviators, and (3) combined action.

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