1.
Dalton Trans
; 52(11): 3279-3286, 2023 Mar 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36633467
RESUMO
Cu(II) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation of N-heteroaromatics reinstates ROS production which leads to efficient DNA cleavage.