[Therapy of lichen sclerosus et atrophicus vulvae with the CO2 silk touch laser]. / Therapie des Lichen sclerosus et atrophicus vulvae mit dem CO2-Silk-touch-Laser.

A 50 year old woman with distinct lichen sclerosus et atrophicus was suffering from severe genital itching, dyspareunia and increasing urinary burning. Therapy attempts with topical glucosteroids and estrogens had been without effort. Treatment with CO2 laser in silk touch mode under insufflation anesthesia to an improvement of her skin lesions and a nearly complete remission of her symptoms.

Recurrent ulcerations on both legs since early childhood due to a factor V gene mutation.

We describe the case of a young man who suffered from recurrent ulcerations on both legs since his early childhood as a result of two coagulation factor abnormalities: factor V gene mutation causing microthrombotic occlusions and subsequently ulcerations and an intermittent factor XIII deficiency responsible for retarded wound healing.

Transformed cells trigger induction of their own apoptosis in coculture with normal cells.

In vitro, transforming growth factor type betal triggers normal cells to induce apoptosis in transformed cells. We show that in the absence of exogenous transforming growth factor type betal, induction of apoptosis of transformed cells in coculture with normal cells is dependent on the number of transformed cells per assay and is abrogated by antibodies against TGF-beta 1. Therefore, transforming growth factor type betal produced by transformed cells seems to be responsible for triggering a mechanism that leads to the induction of their apoptosis. This mechanism may be crucial for the control of carcinogenesis in vivo.