1.
Bioorg Med Chem Lett
; 10(8): 797-800, 2000 Apr 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10782689
RESUMO
5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine was synthesized as a potential bioreductively activated prodrug of 5-fluoro-2'-deoxyuridine (FUDR). The target compound was stable in both phosphate buffer and human serum and was found to release quickly the parent drug FUDR in quantitative yield upon mild chemical reduction.