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Virus Res ; 255: 154-156, 2018 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-30040979

RESUMO

We report a novel tri-genotypic recombinant Hepatitis B virus (HBV) strain circulating in Bangladesh. The strain is recombinant with the genotypes D, C and E, of which, genotype E was not reported before in Bangladesh. Additionally, the complete genome has a frameshift deletion of nine nucleotides from overlapping Surface and Polymerase genes, and a vaccine escape mutation, A128 V, in the surface protein. This is the first report with such unusual recombination event responsible for rapid liver cirrhosis in a 13 year old patient in Bangladesh. This report may alert the clinicians to take the measure to prevent an upcoming outbreak of recombinant HBV.


Assuntos
Vírus da Hepatite B/classificação , Vírus da Hepatite B/genética , Hepatite B/virologia , Cirrose Hepática/virologia , Filogenia , Recombinação Genética/genética , Adolescente , Bangladesh , Composição de Bases , DNA Viral , Tamanho do Genoma , Genoma Viral/genética , Genótipo , Humanos , Polimorfismo Genético , Análise de Sequência de DNA , Deleção de Sequência
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