RESUMO
OBJECTIVES: To evaluate the effects of intra-articular botulinum neurotoxin type A (BoNT/A) in dogs with chronic osteo- arthritis. METHODS: Client-owned dogs with lameness and discomfort attributed to unilateral elbow or hip osteoarthritis were eligible for inclusion (n = 5). All dogs had BoNT/A (25 units) administered to the affected joint (2 elbows, 3 hips). Dogs were evaluated by pressure platform gait analysis before and at two, four, eight, and 12 weeks post-injection, and by client perception of outcome. RESULTS: In experimental limbs, ground reaction forces (peak vertical force and vertical impulse) consistently improved for a variable period of time following intra-articular BoNT/A therapy. These changes were not, however, observed in the contralateral limbs, in which values remained relatively unchanged or decreased. Four out of five owners reported at least some improvement in their dog's condition following treatment. CLINICAL SIGNIFICANCE: A multimodal approach with the intra-articular administration of BoNT/A may be an option for osteoarthritis patients that are unresponsive to medical management and unable to undergo surgery. However, the findings of this study are preliminary and must be verified by further investigation.
Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Doenças do Cão/tratamento farmacológico , Osteoartrite/veterinária , Analgésicos/uso terapêutico , Animais , Toxinas Botulínicas Tipo A/administração & dosagem , Doença Crônica , Cães , Feminino , Seguimentos , Membro Anterior/fisiopatologia , Membro Posterior/fisiopatologia , Humanos , Injeções Intra-Articulares/veterinária , Coxeadura Animal/tratamento farmacológico , Masculino , Orquiectomia/veterinária , Osteoartrite/tratamento farmacológico , Ovariectomia/veterinária , Resultado do TratamentoRESUMO
Fragmented medial coronoid process (FMCP) is a disease process that has not previously been reported in toy-breed dogs. This report describes a presumptive case of FMCP in a 14-month-old Chihuahua that was presented for evaluation approximately four weeks following acute onset of moderate lameness in the left forelimb. Definitive diagnosis of a fragmented medial coronoid process was based upon computed tomography (CT) scan. A CT scan also demonstrated moderate joint incongruity in the affected elbow. Surgical removal of the fragment and subtotal coronoidectomy were performed via a medial arthrotomy. An ulnar ostectomy was also performed to address joint incongruity. Histology of specimens removed at surgery did not demonstrate evidence of microdamage as characteristic of FMCP in large breed dogs, and instead, suggested that the fracture was acute and traumatic in nature. Rapid return to function was observed following surgery.
