Probiotics as functional foods: How probiotics can alleviate the symptoms of neurological disabilities.

Neurological disorders are diseases of the central nervous system with progressive loss of nervous tissue. One of the most difficult problems associated with neurological disorders is that there is no clear treatment for these diseases. In this review, the physiopathology of some neurodegenerative diseases, etiological causes, drugs used and their side effects, and finally the role of probiotics in controlling the symptoms of these neurodegenerative diseases are presented. Recently, researchers have focused more on the microbiome and the gut-brain axis, which may play a critical role in maintaining brain health. Probiotics are among the most important bacteria that have positive effects on the balance of homeostasis via influencing the microbiome. Other important functions of probiotics in alleviating symptoms of neurological disorders include anti-inflammatory properties, short-chain fatty acid production, and the production of various neurotransmitters. The effects of probiotics on the control of abnormalities seen in neurological disorders led to probiotics being referred to as "psychobiotic. Given the important role of the gut-brain axis and the imbalance of the gut microbiome in the etiology and symptoms of neurological disorders, probiotics could be considered safe agents that positively affect the balance of the microbiome as complementary treatment options for neurological disorders.

The relationship between patient safety culture and patient safety competency with adverse events: a multicenter cross-sectional study.

BACKGROUND: Patient safety culture and patient safety competency could be associated with adverse events (AEs). This study aimed to investigate the associations between nurses' perceptions of patient safety culture, patient safety competency, and AEs. METHODS: A cross-sectional study was carried out among 338 nurses employed in three university hospitals in Qom, Iran between 17 August 2021 and 12 November 2021. Data were collected using three questionnaires: patient safety culture, patient safety competency, and AEs. Data were analyzed using SPSS-21 software. A multiple logistic regression model was used to analyze the data. RESULTS: The results of this study showed that medication errors were significantly associated with "frequency of events reported" (OR = 0.706, P = 0.012), "supervisor/manager expectations and actions promoting patient safety" (OR = 0.733, P = 0.048), and "management support for patient safety" (OR = 0.755, P = 0.012). Pressure ulcers were significantly associated with "supervisor/manager expectations and actions promoting patient safety" (OR = 0.729, P = 0.039), "handoffs and transition" (OR = 0.707, P = 0.034), and "comfort speaking up about patient safety" (OR = 0.614, P = 0.016). Falls were significantly associated with "teamwork within units" (OR = 0.735, P = 0.031), "feedback and communication about error" (OR = 0.756, P = 0.046), and "handoffs and transition" (OR = 0.660, P = 0.012). The use of restraints for ≥8 hr. was significantly associated with "management support for patient safety" (OR = 0.701, P = 0.021). CONCLUSIONS: According to the results of this study, AEs are associated with some dimensions of patient safety culture and patient safety competency. Further research is needed to confirm these findings and identify interventions to reduce the occurrence of AEs.