1.
J Org Chem
; 73(24): 9784-7, 2008 Dec 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18956842
RESUMO
The concise enantioselective total synthesis of C(2)-asymmetrical (-)-deoxocuscohygrine and (-)-dihydrocuscohygrine are described. Double-diastereoselective additions of normal Grignard reagent to bis(1,3-oxazolidine) have been deployed to construct chiral diamine fragments as a key step.