Silicon-photonics focused ultrasound detector for minimally invasive optoacoustic imaging.

One of the main challenges in miniaturizing optoacoustic technology is the low sensitivity of sub-millimeter piezoelectric ultrasound transducers, which is often insufficient for detecting weak optoacoustic signals. Optical detectors of ultrasound can achieve significantly higher sensitivities than their piezoelectric counterparts for a given sensing area but generally lack acoustic focusing, which is essential in many minimally invasive imaging configurations. In this work, we develop a focused sub-millimeter ultrasound detector composed of a silicon-photonics optical resonator and a micro-machined acoustic lens. The acoustic lens provides acoustic focusing, which, in addition to increasing the lateral resolution, also enhances the signal. The developed detector has a wide bandwidth of 84 MHz, a focal width smaller than 50 µm, and noise-equivalent pressure of 37 mPa/Hz1/2 - an order of magnitude improvement over conventional intravascular ultrasound. We show the feasibility of the approach and the detector's imaging capabilities by performing high-resolution optoacoustic microscopy of optical phantoms with complex geometries.

Single pixel imaging at megahertz switching rates via cyclic Hadamard masks.

Optical imaging is commonly performed with either a camera and wide-field illumination or with a single detector and a scanning collimated beam; unfortunately, these options do not exist at all wavelengths. Single-pixel imaging offers an alternative that can be performed with a single detector and wide-field illumination, potentially enabling imaging applications in which the detection and illumination technologies are immature. However, single-pixel imaging currently suffers from low imaging rates owing to its reliance on configurable spatial light modulators, generally limited to 22 kHz rates. We develop an approach for rapid single-pixel imaging which relies on cyclic patterns coded onto a spinning mask and demonstrate it for in vivo imaging of C. elegans worms. Spatial modulation rates of up to 2.4 MHz, imaging rates of up to 72 fps, and image-reconstruction times of down to 1.5 ms are reported, enabling real-time visualization of dynamic objects.

Single-pixel imaging of dynamic objects using multi-frame motion estimation.

Single-pixel imaging (SPI) enables the visualization of objects with a single detector by using a sequence of spatially modulated illumination patterns. For natural images, the number of illumination patterns may be smaller than the number of pixels when compressed-sensing algorithms are used. Nonetheless, the sequential nature of the SPI measurement requires that the object remains static until the signals from all the required patterns have been collected. In this paper, we present a new approach to SPI that enables imaging scenarios in which the imaged object, or parts thereof, moves within the imaging plane during data acquisition. Our algorithms estimate the motion direction from inter-frame cross-correlations and incorporate it in the reconstruction model. Moreover, when the illumination pattern is cyclic, the motion may be estimated directly from the raw data, further increasing the numerical efficiency of the algorithm. A demonstration of our approach is presented for both numerically simulated and measured data.

Ultrasound Detection Arrays via Coded Hadamard Apertures.

In the medical fields, ultrasound detection is often performed with piezoelectric arrays that enable one to simultaneously map the acoustic fields at several positions. In this work, we develop a novel method for transforming a single-element ultrasound detector into an effective detection array by spatially filtering the incoming acoustic fields using a binary acoustic mask coded with cyclic Hadamard patterns. By scanning the mask in front of the detector, we obtain a multiplexed measurement data set from which a map of the acoustic field is analytically constructed. We experimentally demonstrate our method by transforming a single-element ultrasound detector into 1-D arrays with up to 59 elements.

Increased SNR in acousto-optic imaging via coded ultrasound transmission.

Acousto-optic imaging (AOI) is a non-invasive method that uses acoustic modulation to map the light fluence inside biological tissue. In many AOI implementations, ultrasound pulses are used in a time-gated measurement to perform depth-resolved imaging without the need for mechanical scanning. However, to achieve high axial resolution, it is required that ultrasound pulses with few cycles are used, limiting the modulation strength. In this Letter, we develop a new approach to pulse-based AOI in which coded ultrasound transmission is used. In coded-transmission AOI (CT-AOI), one may achieve an axial resolution that corresponds to a single cycle, but with a signal-to-noise ratio (SNR) that scales as the square root of the number of cycles. Using CT-AOI with 79 cycles, we experimentally demonstrate over four-fold increase in SNR in comparison to a single-cycle AOI scheme.

Ultrasound Detection Using Acoustic Apertures.

Ultrasound detection is commonly performed by piezoelectric transducers that are optimized for a specific application. Since the piezoelectric technology is not configurable, transducers designed for one application may not be compatible with other applications. In addition, some designs of ultrasound transducers may be difficult to implement owing to production constraints. In this paper, we propose a simple, low-cost method to reconfigure the geometry of ultrasound transducers. The technique is based on using apertures in thin sheets of acoustic blockers. We experimentally demonstrate this method for an ultrasound transducer with a central frequency of 1 MHz and show that it can emulate detectors of various sizes. An added advantage of this technique is its capability to achieve semi-isotropic detection sensitivity due to diffraction when the aperture size is comparable to the acoustic wavelength even when the angular sensitivity of the transducer is inherently limited.

Modeling the sensitivity dependence of silicon-photonics-based ultrasound detectors.

With recent advances in optical technology, interferometric sensing has grown into a highly versatile approach for ultrasound detection, with many interferometric detectors relying on optical waveguides to achieve high levels of sensitivity and miniaturization. In this Letter, we establish a practical model for assessing the sensitivity of silicon-photonics waveguides to acoustic waves. The analysis is performed for different polarizations, waveguide dimensions, and acoustic wave types. Our model was validated experimentally in the acoustic frequency band of 1-13 MHz by measuring the sensitivities of the two polarization modes in a silicon strip waveguide. Both the experimental results and theoretical prediction show that the transverse-magnetic polarization achieves a higher sensitivity and suppression of surface acoustic waves compared to the transverse-electric polarization for the geometries studied.