Contemporary study of strengthening body resistance and archaeus herbs on malignant tumor / 中国中药杂志

[Strengthening body resistance and archaeus herbs are those medicines used on asthenia syndrome of tumor, which can harmonize yin and yang, replenish deficiency of qi and blood, and improve entrails function, enhance physical capacity, and improve immunity function. They are intimate manifestation of strengthening body resistance and archaeus method on clinic. Study shows that strengthening body resistance and archaeus herbs have many effects, such as improving and adjusting immunity function, protecting bone marrow, improving haematogenesis function, raising digest and absorb function, improving substance metabolism, preventing gene mutation, inhibiting tumor cell proliferation, inducing tumor cell differentiation or apoptosis, resisting tumor invasion and metastasis, inhibiting formation of tumor vessel and activity of telomerase, etc. It's possibly the result of synergistic effect by multi-pathway and multi-target. Because strengthening body resistance and archaeus herbs are of variety and different herbs have different specificity, further research is needed to reveal the precise mechanism of them.

Study on effect of arsenic trioxide on adhesion and invasion of human hepatocarcinoma cells in vitro / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To explore that the arsenic trioxide injection (ATI) has the effect in antagonizing adhesion and invasion of human hepatocarcinoma cells (HCC), and its relevant mechanism.</p><p><b>METHODS</b>Human hepatocellular carcinoma cell line SMMC-7721 and the high metastatic nude mice human HCC in situ transplantation model was taken as the objects of study, the effects of ATI on the SMMC-7721 cell movement and migration, its adhesion with fibronectin (FN) and endothelial cell (EC), as well as the CD44 and MMP-2 gene protein expression in transplanted tumor of the model mice were observed by means of cell movement and migration test, cell adhesion test and immunohistochemical method.</p><p><b>RESULTS</b>ATI could significantly inhibit SMMC-7721 cell movement and migration on FN, adhesion with FN and EC, also could lower CD44 and MMP-2 in cancer cells.</p><p><b>CONCLUSION</b>ATI has the effects of antagonizing hepatocarcinoma cell adhesion and invasion, the mechanism may be related with the action of ATI in lowering CD44 and MMP-2 expression in cancer cells.</p>