RESUMO
Objective To investigate the influence of magnesium sulfate on C-reactive protein, white blood cells, neutrophils, gastrointestinal function and serum bilirubin levels in patients with acute cholecystitis.Methods 117 patients with acute cholecystitis were randomly divided into two groups (n=60) and control group (n=57).The control group received conventional treatment, and observation group received conventional treatment combined with magnesium sulfate.The leukocyte count and neutrophil percentage, serum total bilirubin and CRP levels, plasma vasoactive intestinal peptide ( VIP) and motilin ( MTL) levels, and disappearance time of fever, abdominal pain, gallbladder enlargement were analysed between two groups of patients.Results After treatment, the leukocyte count and neutrophil percentage of observation group were significantly lower than those before treatment (P<0.05), but there were no significantly differences in above indexes of control group; after treatment, leukocyte count and neutrophil percentage in observation group were significantly lower than those in control group (P<0.05).After treatment, serum CRP and total bilirubin levels in observation group was significantly lower than that before treatment (P<0.05), and CRP level in control group was significantly lower than that before treatment (P<0.05), while total bilirubin level in control group showed no significant change; after treatment, the above indexes in observation group were significantly lower than that in control group (P<0.05).After treatment, plasma VIP levels in both groups was significantly lower than that before treatment, respectively (P<0.05), MTL levels were significantly higher than that before treatment, respectively (P<0.05);after treatment, VIP level was lower, MTL level was higher in observation group than that in control group, respectively (P<0.05).The disappearance time of fever, abdominal pain, gallbladder enlargement in observation group were significantly shorter than that in control group, respectively ( P<0.05 ) .Conclusion The mechanism of magnesium sulfate in the treatment of acute cholecystitis may reduce leukocyte count and neutrophil percentage, serum CRP and total bilirubin, plasma VIP level and increase MTL level.
