Synthesis of (+)-ambrisentan / 中国药科大学学报

A five-step synthetic method of ambrisentan starting from benzophenone was developed.The reaction methods of resolution and substitution were optimized.A stable,facilitating method of detection and efficient resolution reagent,L-phenylglycinamide,was used and helped to obtain highly optical pure intermediates.In the substitution reaction,NaOH was chosen as the base,which is safe and suitable for the industry.This method was mild,easily operated with a total yield up to 31.0％,and may have a good application prospect.

Progress in therapy and prognosis of childhood Henoch-Sch(o)nlein purpura nephritis / 国际儿科学杂志

Henoch-Sch(o)nlein purpura nephritis (HSPN)is primarily treated with medication. Especially, glucocorticoid and immunosuppressants can control the clinical features and improve its prognosis effectively.Overall prognosis of HSPN is relatively good, but patients with severe clinical presentations and renal insufficiency will be worse.Better interventions of HSPN can be provided through extensive analysis of the treatment and prognosis.