Untreated thyrotoxicosis as a manifestation of anorexia nervosa.

A patient with anorexia nervosa refused treatment for her thyrotoxicosis for 18 years in an attempt to keep her weight low. Severe congestive heart failure and impending thyroid storm prompted her family to force her to seek medical attention.

Clofibrate-induced myotoxicity in rats. Temporal profile of myopathology.

In this report, the temporal sequence of myopathology during a clofibrate-induced muscular syndrome and its recovery in rats is described using histopathologic, histochemical and electron microscopic technics. Two stages of myopathology are described: an early stage characterized by myopathic features, and a later stage characterized by neurogenic features. Although muscle histology returns to normal after 1 week of discontinuing the drug, electron microscopic abnormalities persist through the second week. It is proposed that clofibrate, in addition to its myotoxic effect, may be neurotoxic.