[Iris metastatic thyroid follicular carcinoma: a case report]. / Métastase irienne d'un carcinome folliculaire de la thyroïde: à propos d'un cas.

Metastatic carcinoma of the iris is rare and accounts for 5-10% of uveal metastasis and 3% of all iris lesions. Breast and lung carcinoma are the primary sites in 90% of patients. We report here the case of a 66-year-old man treated in 1992 for follicular thyroid carcinoma and hospitalized in 1995 for a pink vascularized mass in the iris. At that time, neither local recurrence nor metastasis in other organs was observed. Histopathologic findings were typical of follicular thyroid metastasis carcinoma. The patient had refused adjuvant treatment but was followed up for 23 months after the diagnosis of the iris metastasis. Through this observation and a literature review, we discuss clinicopathological and prognosis aspects of this exceptional location.

[Two cases of subretinal neovascular membrane in Vogt-Koyanagi-Harada syndrome]. / Néovaisseaux choroïdiens compliquant une maladie de Vogt-Koyanagi-Harada.

AIM: To report two cases of Vogt-Koyanagi-Harada syndrome (VKH) complicated by subretinal neovascularization. CASE REPORTS: The first patient was a 12-year-old girl in whom choroidal neovascularization occurred after VKH had evolved for 9 months. Fundus examination of the left eye revealed a macular extrafoveolar superior serous retinal detachment (SRD) centered by a grey-white pseudo-tumoral zone. A crown of exudates lined the SRD. Pigment epithelium impairment was substantial. Fluorescein angiography showed an early intensive and diffuse staining in the left eye corresponding to a neovascular membrane associated with a late impregnation of the SRD. Green monochromatic laser photocoagulation was considered but refused by the parents. The second patient was an 18-year-old girl followed up for VKH for 2 years. Ophthalmoscopy showed a serous retinal detachment with hemorrhage and hard exudates in the right eye. Fluorescein angiography showed early staining in the juxtapapillary region corresponding to a juxtapapillary neovascular membrane. High-dose systemic corticotherapy was instituted. Photocoagulation was not indicated because of the juxtapapillary topography of the neovascular membrane. CONCLUSION: VKH is a bilateral panuveitis that can be complicated by subretinal neovascularization in 2.5%-10% of cases. This complication must be diagnosed early. We discuss angiogenic factors and therapeutic modalities.