RESUMO
Cerebral angiography still remains the method of choice for the evaluation of cerebral vascular malformations--even in this day and age of CT. In rare cases, however, these conditions can be missed by angiography, whereas CT can provide important though not pathognomonic clues, with a definite diagnosis possible only by surgical exploration.
Assuntos
Angiografia Cerebral , Malformações Arteriovenosas Intracranianas/diagnóstico por imagem , Adolescente , Adulto , Neoplasias Encefálicas/diagnóstico por imagem , Feminino , Hemangioma/diagnóstico por imagem , Humanos , Tomografia Computadorizada por Raios XAssuntos
6-Aminonicotinamida , Química Encefálica , Di-Hidroxifenilalanina/análise , Niacinamida , Doença de Parkinson Secundária/induzido quimicamente , Animais , Corpo Estriado/análise , Diencéfalo/análise , Eletromiografia , Levodopa/uso terapêutico , Sistema Límbico/análise , Lisurida/uso terapêutico , Masculino , Músculos/fisiopatologia , Niacinamida/análogos & derivados , Doença de Parkinson Secundária/tratamento farmacológico , Doença de Parkinson Secundária/fisiopatologia , Ratos , Tirosina/análiseRESUMO
In corpus striatum, 6-aminonicotinamide (6-AN), 10 mg/kg i.p. lowered the concentration of dopamine and markedly reduced the disappearance of dopamine after synthesis inhibition with alpha-methyl-p-tyrosine. In the dopamine-rich part of the limbic system, the formation of DOPA after decarboxylase inhibition with 3-hydroxybenzylhydrazine was decreased. In diencephalon, 6-AN altered neither the steady-state level nor the utilization of noradrenaline. The data suggest that the muscular rigidity induced by 6-AN may be associated with disruption of dopaminergic transmission.
Assuntos
6-Aminonicotinamida/farmacologia , Dopamina/fisiologia , Rigidez Muscular/induzido quimicamente , Niacinamida/análogos & derivados , Animais , Química Encefálica/efeitos dos fármacos , Catecolaminas/metabolismo , Hidrazinas/farmacologia , Masculino , Metiltirosinas/farmacologia , Ratos , Fatores de TempoAssuntos
6-Aminonicotinamida/efeitos adversos , Antipsicóticos/farmacologia , Doenças do Sistema Nervoso Central/induzido quimicamente , Modelos Animais de Doenças , Niacinamida/análogos & derivados , Doença de Parkinson Secundária/induzido quimicamente , Animais , Baclofeno/farmacologia , Encéfalo/metabolismo , Química Encefálica , Bromocriptina/uso terapêutico , Dopamina/farmacologia , Avaliação Pré-Clínica de Medicamentos , Eletromiografia , Gluconatos/líquido cefalorraquidiano , Levodopa/farmacologia , Levodopa/uso terapêutico , Lisurida/uso terapêutico , Masculino , Neurônios Motores/efeitos dos fármacos , Contração Muscular/efeitos dos fármacos , Doença de Parkinson Secundária/tratamento farmacológico , Doença de Parkinson Secundária/patologia , RNA/biossíntese , Ratos , Reserpina/efeitos adversos , Medula Espinal/análise , Fosfatos Açúcares/líquido cefalorraquidianoRESUMO
In rats the application of 10 mg/kg 6-amino-nicotinamide (6-AN) leads to an accumulation of 6-phosphogluconate, by inhibition of 6-phosphogluconate dehydrogenase in the pentose phosphate pathway, in the cells of the spinal cord. The accumulation reaches its maximum after 18-24 h. It seems that there exists a relationship between the accumulation of 6-phosphogluconate and the lesion of the neuroglia, which is found in electron microscopic studies. Symptoms of a spastic paresis only develop later when the spinal interneurones are destroyed as a consequence of the lesion of the neuroglia. The accumulation of 6-phosphogluconate almost exceeds the 400 fold of the norm. No considerable differences are found between the effects of a dose of 35 mg 6-AN/kg and one of 10 mg 6-AN/kg. Free gluconate is identified enzymically in the cells of the spinal cords of the rats treated with 6-AN. The compound is very probably formed by dephosphorylation and diffuses into the blood. 6-Phosphogluconate is an inhibitor of the phosphoglucose isomerase. Its accumulation shifts the equilibrium towards glucose 6-phosphate. The lactate concentration decreases as compared with the untreated controls. Muscular action potentials are recorded extracellularly with a concentric needle electrode from the musculus gastrocnemius of rats treated with 6-AN. First activations of the electromyograms are found 48 h after the application of 10 mg 6-AN/kg. The electrical activities increase during the time in which a progressive destruction of the interneurones occurs. The electromyogram displays a permanent state of excitation with high amplitudes and an increased frequency. The continuity and intensity of the increased activity recorded by the electromyograph is the most important pathological finding. p-Chlorophenyl-GABA and, still more so, chlorpromazine cause temporary reduction of the excitation processes and an electromyogram nearly at rest. Under the same conditions, haloperidol is only slightly effective. The symptoms developed by the chemical destruction of the interneurones of the spinal cord, with rigidity and spasticity of the hind limbs, are suitable for testing antispastic drugs.