An ovine knee simulator: description and proof of concept.

Aims: The ovine stifle is an established model for evaluation of knee treatments, such as meniscus replacement. This study introduces a novel ovine gait simulator for pre-testing of surgical treatments prior to in vivo animal trials. Furthermore, we describe a pilot study that assessed gait kinematics and contact pressures of native ovine stifle joints and those implanted with a novel fiber-matrix reinforced polyvinyl alcohol-polyethylene glycol (PVA-PEG) hydrogel meniscus to illustrate the efficacy of the simulator. Methods: The gait simulator controlled femoral flexion-extension and applied a 980N axial contact force to the distal tibia, whose movement was guided by the natural ligaments. Five right ovine stifle joints were implanted with a PVA-PEG total medial meniscus replacement, fixed to the tibia via transosseous tunnels and interference screws. Six intact and five implanted right ovine stifle joints were tested for 500 k gait cycles at 1.55 Hz. Implanted stifle joint contact pressures and kinematics in the simulator were compared to the intact group. Contact pressures were measured at 55° flexion using pressure sensitive film inserted sub-meniscally. 3D kinematics were measured optically across two 30-s captures. Results: Peak contact pressures in intact stifles were 3.6 ± 1.0 MPa and 6.0 ± 2.1 MPa in the medial and lateral condyles (p < 0.05) and did not differ significantly from previous studies (p > 0.4). Medial peak implanted pressures were 4.3 ± 2.2 MPa (p > 0.4 versus intact), while lateral peak pressures (9.4 ± 0.8 MPa) were raised post medial compartment implantation (p < 0.01). The range of motion for intact joints was flexion/extension 37° ± 1°, varus/valgus 1° ± 1°, external/internal rotation 5° ± 3°, lateral/medial translation 2 ± 1 mm, anterior/posterior translation 3 ± 1 mm and distraction/compression 1 ± 1 mm. Ovine joint kinematics in the simulator did not differ significantly from published in vivo data for the intact group, and the intact and implanted groups were comparable (p > 0.01), except for in distraction-compression (p < 0.01). Conclusion: These findings show correspondence of the ovine simulator kinematics with in vivo gait parameters. The efficacy of the simulator to evaluate novel treatments was demonstrated by implanting a PVA-PEG hydrogel medial meniscal replacement, which restored the medial peak contact pressures but not lateral. This novel simulator may enable future work on the development of surgical procedures, derisking subsequent work in live animals.

Enhancing acetabular reaming accuracy: optimal techniques and a novel reamer design.

INTRODUCTION: Successful press-fit implantation relies on an accurately reamed bone cavity. Inaccurate reaming can lead to a suboptimal press-fit risking fracture and cup deformation or excessive micromotion and loosening. Several factors may impact reaming accuracy including the reamer design, the surgeon's technique and the bone quality. The aim of this study is to investigate the accuracy of reaming techniques and the accuracy of a novel reamer design. METHODS: Eighty composite bone models, half high density and half low density, were reamed with either a conventional or an additively manufactured reamer with a novel design employing either a straight or 'whirlwind' reaming technique. Reamed cavities were scanned using a 3D laser scanner and the median difference between achieved and expected diameters compared. RESULTS: The novel reamer design was more accurate than the unused conventional reamer, using both whirlwind (0.1 mm (IQR 0-0.2) vs. 0.3 mm (IQR 0.3-0.4); p < 0.001) and straight techniques (0.3 mm (IQR 0.1-1.0) vs. 1.2 mm (IQR 1-1.6); p = 0.001). Whirlwind reaming was more accurate than straight reaming using both conventional (0.3 mm (IQR 0.3-0.4) vs. 1.2 mm (IQR 1-1.6); p < 0.0001) and single use reamers (0.1 mm (IQR 0-0.2) vs. 0.3 mm (IQR 0.1-1.0); p = 0.007). Reaming errors were higher in low-density bone compared to high-density bone, for both reamer types and reaming techniques tested (0.6 mm (IQR 0.3-1.5) vs. 0.3 mm (IQR 0.1-0.8); p = 0.005). CONCLUSION: We present a novel reamer design that demonstrates superior accuracy to conventional reamers in achieving the desired reaming diameter. Improved reaming accuracy was also demonstrated using both devices and in both bone models, using a 'whirlwind' technique. We recommend the use of this novel reamer design employing a 'whirlwind' technique to optimize reaming accuracy. Particular attention should be paid toward patients with lower bone quality which may be more susceptible to higher inaccuracies.

Hip resurfacing arthroplasty in women: A novel ceramic device enables near normal gait function.

BACKGROUND: Gait function improves after Total Hip Arthroplasty (THA) but is not restored to normal levels. Metal-on-metal Resurfacing Arthroplasty (MoM-HRA) is an alternative to THA and has shown to restore normal levels gait function and physical activity but has been restricted to men owing to problems of metal-ion release. Ceramic HRA (cHRA) removes the cobalt-chrome bearing surfaces, thereby eliminating these specific metal-ion concerns and aiming to be safe for females. RESEARCH QUESTION: Is there a difference in gait function of female cHRA patients compared to female THA using subjective and objective measures? METHODS: Fifteen unilateral cHRA and 15 unilateral THA, age and BMI matched, completed patient reported outcome measures (PROMs) (Oxford Hip Score, EQ5d and MET score) and underwent gait analysis using an instrumented treadmill pre- (2-10 weeks) and post-operatively (52-74 weeks). Maximum walking speed (MWS), Vertical GRF of the stance phase, GRF symmetry index (SI) and spatiotemporal gait measures were recorded. Patients were compared to age, gender and BMI healthy controls (CON). RESULTS: There were no differences in PROMs or gait function between groups pre-operatively. Post- operatively, cHRA had a higher MET score (11.2 vs 7.1, p = 0.02) and a higher MWS (6.2 vs 6.8 km/hr, p = 0.003) compared to THA. cHRA had a similar GRF profile to CON, whereas THA had a reduced push-off force at 70-77 % of the stance phase compared to CON. At faster walking speeds of 6 km/hr walking speed, THA displayed an asymmetric GRF profile (SI<4.4 %) whereas the cHRA patients continued to display a symmetrical gait profile. cHRA was able to increase step length from pre-op levels (63 vs 66 cm, p = 0.02) and produced a larger step length compared to THA (73 vs 79 cm, p = 0.02). SIGNIFICANCE: Female cHRA returned to levels of gait function and activity similar to healthy controls unlike female THA.

Low dose CT-based spatial analysis (CTSA) to measure implant migration after ceramic hip resurfacing arthroplasty (HRA): A phantom study.

Implant migration is a predictor of arthroplasty survivorship. It is crucial to monitor the migration of novel hip prostheses within premarket clinical investigations. RSA is the gold standard method, but requires calibrated radiographs using specialised equipment. A commercial computed tomography micromotion analysis solution is a promising alternative but is not yet available for use with monobloc ceramic implants. This study aimed to develop and validate a CT-based spatial analysis (CTSA) method for use with ceramic implants. A phantom study was undertaken to assess accuracy and precision. A ceramic hip resurfacing arthroplasty (HRA) and 20 tantalum beads were implanted into a synthetic hip model and mounted onto a 6-degree of freedom motion stage. The hip was repeatedly scanned with a low dose CT protocol, with imposed micromovements. Data were interrogated using a semiautomated technique. The effective radiation dose for each scan was estimated to be 0.25 mSv. For the head implant, precision ranged between 0.11 and 0.28 mm for translations and 0.34°-0.42° for rotations. For the cup implant, precision ranged between 0.08 and 0.11 mm and 0.19° and 0.42°. For the head, accuracy ranged between 0.04 and 0.18 mm for translations and 0.28°-0.46° for rotations. For the cup, accuracy ranged between 0.04 and 0.08 mm and 0.17° and 0.43°. This in vitro study demonstrates that low dose CTSA of a ceramic HRA is similar in accuracy to RSA. CT is ubiquitous, and this method may be an alternative to RSA to measure prosthesis migration.

A single-use, size-specific, nylon arthroplasty guide: a preliminary study for hip resurfacing.

INTRODUCTION: In arthroplasty surgery, positioning of the components must be accurate and reproducible to avoid complications. Conventional guides are often used to align a component, but they require surgical skill and experience, and are prone to error. To this end, a single-use, size-specific, nylon guide (single-use nylon guide) has been developed for the purpose of increasing the accuracy without adding extra cost to the operation. The effectiveness of this type of guide was evaluated in using a synthetic bone study. METHODS: A total of 66 synthetic femurs with the same osteoarthritic morphology were prepared. 3 surgeons participated in the experiments, and each surgeon created a drill hole for the femoral component by using the single-use nylon guide or a commercially-available, conventional, metal, neck-based guide (conventional guide). Anteversion, inclination, and insertion point acquired by the guide were compared between the guides, between surgeons, and to the computer-based plan. RESULTS: Anteversion acquired by the single-use nylon guide (6.7° [4.9-11.5°]) was significantly closer to the plan (14.6°) than that acquired by the conventional guide (4.3° [2.4-8.6°]) (p = 0.03). The insertion point was also significantly closer to the plan for the single-use nylon guide (3.8 mm ± 1.6 mm) than the conventional guide (5.7 mm ± 2.4 mm) (p < 0.001). No significant difference was found for the inclination (p = 0.76). CONCLUSION: A single-use, size-specific nylon guide was effective in acquiring a higher accuracy and precision in anteversion and insertion point than a conventional guide in this synthetic bone, hip resurfacing arthroplasty study. The use of single-use guides in other orthopaedic procedures should be explored.

Posteromedial Meniscocapsular Lesions Increase Tibiofemoral Joint Laxity With Anterior Cruciate Ligament Deficiency, and Their Repair Reduces Laxity.

BACKGROUND: Injury to the posteromedial meniscocapsular junction has been identified after anterior cruciate ligament (ACL) rupture; however, there is a lack of objective evidence investigating how this affects knee kinematics or whether increased laxity can be restored by repair. Such injury is often overlooked at surgery, with possible compromise to results. HYPOTHESES: (1) Sectioning the posteromedial meniscocapsular junction in an ACL-deficient knee will result in increased anterior tibial translation and rotation. (2) Isolated ACL reconstruction in the presence of a posteromedial meniscocapsular junction lesion will not restore intact knee laxity. (3) Repair of the posteromedial capsule at the time of ACL reconstruction will reduce tibial translation and rotation to normal. (4) These changes will be clinically detectable. STUDY DESIGN: Controlled laboratory study. METHODS: Nine cadaveric knees were mounted in a test rig where knee kinematics were recorded from 0° to 100° of flexion by use of an optical tracking system. Measurements were recorded with the following loads: 90-N anterior-posterior tibial forces, 5-N·m internal-external tibial rotation torques, and combined 90-N anterior force and 5-N·m external rotation torque. Manual Rolimeter readings of anterior translation were taken at 30° and 90°. The knees were tested in the following conditions: intact, ACL deficient, ACL deficient and posteromedial meniscocapsular junction sectioned, ACL deficient and posteromedial meniscocapsular junction repaired, ACL patellar tendon reconstruction with posteromedial meniscocapsular junction repair, and ACL reconstructed and capsular lesion re-created. Statistical analysis used repeated-measures analysis of variance and post hoc paired t tests with Bonferroni correction. RESULTS: Tibial anterior translation and external rotation were both significantly increased compared with the ACL-deficient knee after posterior meniscocapsular sectioning (P < .05). These parameters were restored after ACL reconstruction and meniscocapsular lesion repair (P > .05). CONCLUSION: Anterior and external rotational laxities were significantly increased after sectioning of the posteromedial meniscocapsular junction in an ACL-deficient knee. These were not restored after ACL reconstruction alone but were restored with ACL reconstruction combined with posterior meniscocapsular repair. Tibial anterior translation changes were clinically detectable by use of the Rolimeter. CLINICAL RELEVANCE: This study suggests that unrepaired posteromedial meniscocapsular lesions will allow abnormal meniscal and tibiofemoral laxity to persist postoperatively, predisposing the knee to meniscal and articular damage.

Anteroposterior Laxity After Bicruciate-Retaining Total Knee Arthroplasty Is Closer to the Native Knee Than ACL-Resecting TKA: A Biomechanical Cadaver Study.

The purpose of this study was to examine whether a bicruciate retaining (BCR) TKA would yield anteroposterior (AP) laxity closer to the native knee than a posterior cruciate ligament retaining (CR) TKA. A BCR TKA was designed and compared to CR TKA and the native knee using cadaver specimens. AP laxity with the CR TKA was greater than the native knee (P=0.006) and BCR TKA (P=0.039), but no difference was found between the BCR TKA and the native knee. No significant differences were found in rotations between the prostheses and the native knee. BCR TKA was shown to be surgically feasible, reduced AP laxity versus CR TKA, and may improve knee stability without using conforming geometry in the implant design.

Clinically relevant biomechanics of the knee capsule and ligaments.

The paper describes the concepts of primary and secondary restraints to knee joint stability and explains systematically how the tibia is stabilised against translational forces and rotational torques in different directions and axes, and how those vary across the arc of flexion-extension. It also shows how the menisci act to stabilise the knee, in addition to load carrying across the joint. It compares the properties of the natural stabilising structures with the strength and stiffness of autogenous tissue grafts and relates those strengths to the strength of graft fixation devices. A good understanding of the biomechanical behaviour of these various structures in the knee will help the surgeon in the assessment and treatment of single and multi-ligament injuries.

Length change patterns in the lateral extra-articular structures of the knee and related reconstructions.

BACKGROUND: Lateral extra-articular soft tissue reconstructions in the knee may be used as a combined procedure in revision anterior cruciate ligament surgery as well as in primary treatment for patients who demonstrate excessive anterolateral rotatory instability. Only a few studies examining length change patterns and isometry in lateral extra-articular reconstructions have been published. PURPOSE: To determine a recommended femoral insertion area and graft path for lateral extra-articular reconstructions by measuring length change patterns through a range of knee flexion angles of several combinations of tibial and femoral insertion points on the lateral side of the knee. STUDY DESIGN: Controlled laboratory study. METHODS: Eight fresh-frozen cadaveric knees were freed of skin and subcutaneous fat. The knee was then mounted in a kinematics rig that loaded the quadriceps muscles and simulated open-chain knee flexion. The length changes of several combinations of tibiofemoral points were measured at knee flexion angles between 0° and 90° by use of linear variable displacement transducers. The changes in length relative to the 0° measurement were recorded. RESULTS: The anterior fiber region of the iliotibial tract displayed a significantly different (P < .001) length change pattern compared with the posterior fiber region. The reconstructions that had a femoral insertion site located proximal to the lateral epicondyle and with the grafts passed deep to the lateral collateral ligament displayed similar length change patterns to each other, with small length increases during knee extension. These reconstructions also showed a significantly lower total strain range compared with the reconstruction located anterior to the epicondyle (P < .001). CONCLUSION: These findings show that the selection of graft attachment points and graft course affects length change pattern during knee flexion. A graft attached proximal to the lateral femoral epicondyle and running deep to the lateral collateral ligament will provide desirable graft behavior, such that it will not suffer excessive tightening or slackening during knee motion. CLINICAL RELEVANCE: These results provide a surgical rationale for lateral extra-articular soft tissue reconstruction in terms of femoral graft fixation site and graft route.

Kinematic behaviour and soft tissue management in guided motion total knee replacement.

PURPOSE: Dissatisfaction after total knee arthroplasty (TKA) may be caused by abnormal knee kinematics, and there is concern that 'guided motion' TKAs, designed to replicate normal knee kinematics, cause anterolateral knee pain due to stretching of soft tissues. It was hypothesised that excessive tibial internal rotation and femoral rollback during flexion were to blame. METHODS: Eighteen fresh-frozen specimens were used in two studies. The first study used a knee extension rig and transducers to measure ligament length changes during flexion. The second study used a knee flexion rig and optical trackers to measure tibiofemoral kinematics. Both experiments used the intact knee and were repeated with three TKAs: two guided motion (Journey and Journey II) and a conventional Genesis II PS TKA. RESULTS: TKA did not cause significant elongation of any of the ligaments examined. The medial patellofemoral ligament and the medial collateral ligament tended to be slacker post-TKA, and all three TKAs caused some tightening of the superficial iliotibial band, but these changes were not significant. Normal knee kinematics was not restored by any of the devices. The screw-home mechanism was absent in all three TKAs; anterior laxity was increased in all three devices up to 90° flexion, but tibial internal rotation was not increased. The conventional TKA allowed significantly greater anterior laxity than normal, while the Journey I caused greater tibial anterior translation in flexion. CONCLUSIONS: The hypothesis that over-internal rotation and rollback in the original guided motion knee caused excessive tightening in the soft tissues around the knee was supported; the updated design reduced that tendency. If similar changes occur during real-life activities, these results imply a potential reduction in the incidence of anterolateral knee pain clinically in patients with a guided motion TKA.

Biomechanical comparisons between 4-strand and modified Larson 2-strand procedures for reconstruction of the posterolateral corner of the knee.

BACKGROUND: The posterolateral corner (PLC) resists tibial varus angulation, external rotation, and, to a lesser extent, posterior translation. It is important that reconstructions of posterolateral knee injuries restore joint laxity and patient function, but residual laxities are often observed. HYPOTHESIS: The knee laxity after a new 4-strand PLC reconstruction would be closer to normal than after a 2-strand "modified Larson" reconstruction. STUDY DESIGN: Controlled laboratory study. METHODS: Fourteen intact cadaveric knees were mounted in a 6 degrees of freedom rig and subjected to the following external loading conditions: a 90-N posterior tibial force, a 5-N·m external rotation torque, and 5-N·m varus moment. Knee kinematics were recorded with an active optical tracking system for the intact, PLC-deficient, modified Larson PLC reconstruction and 4-strand PLC reconstruction. RESULTS: With external tibial torque, the rotational laxity in 4-strand reconstruction was significantly less than in the PLC-deficient (P < .0001) and modified Larson reconstruction (P = .0112) and did not differ significantly from intact laxity at any angle of flexion. In response to posterior load, posterior translation did not change in any of the tested conditions, while the coupled external rotation laxity in 4-strand PLC reconstruction was significantly less than in the PLC-deficient (P < .0001) and modified Larson reconstruction (P < .0486) and was not significantly different from the intact movements for both reconstructions. The varus angulation-versus-flexion curves were significantly different between the PLC-deficient and both PLC reconstructions (P < .0001). The varus laxity was not significantly different between the modified Larson reconstruction, the 4-strand reconstruction, and the intact knee. CONCLUSION: This study showed that the rotational knee laxity in response to both external rotation and posterior translation load were significantly better after the 4-strand PLC reconstruction than after the modified Larson reconstruction, although significant differences were not found between the 2 procedures for varus laxity. CLINICAL RELEVANCE: The 4-strand PLC reconstruction may produce a better biomechanical outcome, especially during external rotation and posterior translation tibial load. The authors suggest that this relates to load sharing among 4 graft strands crossing the joint.

The fixation strength of a novel ACL soft-tissue graft fixation device compared with conventional interference screws: a biomechanical study in vitro.

Anterior cruciate ligament reconstruction using autologous hamstring tendons is an established surgical procedure but some grafts fail due to poor fixation. This study compared the fixation of a new ACL graft fixation device (the EZ KneeSpan) to conventional soft-tissue threaded titanium interference screws (IS). The EZ device was designed to provide secure fixation while avoiding soft-tissue graft damage associated with use of an IS. Eight paired fresh-frozen cadaveric human knees and bovine digital extensor tendons were used. Two tunnels were placed in each tibia and femur, and grafts were fixed using the EZ device and the IS in each bone. Cyclic tensile loading and pull-out testing measured graft slippage (mm) and ultimate strength (N) of the fixation. The results were compared using the non-parametric Wilcoxon signed-rank test. Graft slippage after cyclic loading was significantly lower in the EZ group at 2.4 ± 0.1 mm versus 9.5 ± 6.2 mm for the IS group in the femur and 3.3 ± 1.4 mm versus 17.7 ± 13.6 mm in the tibia. The mean ultimate load for the femoral EZ group was significantly higher than the IS group (769 ± 223 N versus 468 ± 60 N), but they did not differ significantly in the tibia (518 ± 48 N versus 546 ± 139 N). Our results indicate that with the EZ device the initial fixation of cyclically loaded hamstring grafts could be superior to that with an IS. The EZ KneeSpan device also had similar tibial and higher femoral ultimate fixation strength than an IS.