Association between pre-eclampsia and inherited thrombophilias.

OBJECTIVE: The aim was to determine whether inherited thrombophilia increases the risk of pre-eclampsia (PE) or interferes with its clinical course. MATERIAL AND METHODS: We included 50 patients with severe PE and 50 healthy pregnant women. Patients were evaluated for inherited thrombophilia. RESULTS: Fourteen patients in the study group was factor V Leiden (FVL) carrier while it was 12% in the control group. In women with PE, FVL and other inherited thrombophilic factors were not more prevalent than in the controls. CONCLUSION: The present study failed to demonstrate an association between the inherited thrombophilias and PE.