RESUMO
The androgen receptor (AR) is a member of the family of ligand-activated transcription factors. Selective androgen receptor modulators (SARMs) exert their biological function through complex interactions with the AR. It has been speculated that overexertion of AR signaling cascades as a result of SARM abuse can be a risk factor for the development of various cardiovascular diseases. The present literature review explores the implications of the interaction between SARMs and the AR on cardiovascular health by focusing on the AR structure, function, and mechanisms of action, as well as the current clinical literature on various SARMs. It is shown that SARMs may increase the risk of cardiovascular diseases through implications on the renin-angiotensin system, smooth muscle cells, sympathetic nervous system, lipid profile, inflammation, platelet activity, and various other factors. More research on this topic is necessary as SARM abuse is becoming increasingly common. There is a noticeable lack of clinical trials and literature on the relationship between SARMs, cardiovascular diseases, and the AR. Future in vivo and in vitro studies within this field are vital to understand the mechanisms that underpin these complex interactions and risk factors.
Assuntos
Doenças Cardiovasculares , Receptores Androgênicos , Humanos , Androgênios , Antagonistas de Receptores de Andrógenos , LigantesRESUMO
El uso de desinfectantes químicos y esterilizantes en la práctica dental, constituyen una parte significativa del control de la infección. Sin embargo, el número creciente de tales agentes en el mercado y las aparentes quejas conflictivas de los fabricantes, crean dificultades en la selección de los productos apropiados para el uso en el consultorio dental. Este artículo brinda una selección de desinfectantes y esterilizantes
