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1.
Cerebrovasc Dis Extra ; 7(1): 44-50, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28259883

RESUMO

BACKGROUND: Dysphagia is one of the most dangerous symptoms of acute stroke. Various screening tools have been suggested for the early detection of this condition. In spite of conflicting results, measurement of oxygen saturation (SpO2) during clinical swallowing assessment is still recommended by different national guidelines as a screening tool with a decline in SpO2 ≥2% usually being regarded as a marker of aspiration. This paper assesses the sensitivity of SpO2 measurements for the evaluation of aspiration risk in acute stroke patients. METHODS: Fifty acute stroke patients with moderate to severe dysphagia were included in this study. In all patients, fiberoptic endoscopic evaluation of swallowing (FEES) was performed according to a standardised protocol. Blinded to the results of FEES, SpO2 was monitored simultaneously. The degree of desaturation during/after swallows with aspiration was compared to the degree of desaturation during/after swallows without aspiration in a swallow-to-swallow analysis of each patient. To minimise potential confounders, every patient served as their control. RESULTS: In each subject, a swallow with and a swallow without aspiration were analysed. Overall, aspiration seen in FEES was related to a minor decline in SpO2 (mean SpO2 without aspiration 95.54 ± 2.7% vs. mean SpO2 with aspiration 95.28 ± 2.7%). However, a significant desaturation ≥2% occurred only in 5 patients during/after aspiration. There was no correlation between aspiration/dysphagia severity or the amount of aspirated material and SpO2 levels. CONCLUSIONS: According to this study, measurement of oxygen desaturation is not a suitable screening tool for the detection of aspiration in stroke patients.


Assuntos
Monitorização Transcutânea dos Gases Sanguíneos , Transtornos de Deglutição/diagnóstico , Deglutição , Oxigênio/sangue , Aspiração Respiratória de Conteúdos Gástricos/etiologia , Acidente Vascular Cerebral/complicações , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Transtornos de Deglutição/sangue , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/fisiopatologia , Feminino , Tecnologia de Fibra Óptica , Humanos , Laringoscopia , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Aspiração Respiratória de Conteúdos Gástricos/diagnóstico , Aspiração Respiratória de Conteúdos Gástricos/fisiopatologia , Medição de Risco , Fatores de Risco , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/fisiopatologia
2.
J Clin Microbiol ; 54(11): 2820-2824, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27629893

RESUMO

With the increasing prevalence of multidrug-resistant Gram-negative bacteria, rapid identification of the pathogen and its individual antibiotic resistance is crucial to ensure adequate antiinfective treatment at the earliest time point. Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry for the identification of bacteria directly from the blood culture bottle has been widely established; however, there is still an urgent need for new methods that permit rapid resistance testing. Recently, a semiquantitative MALDI-TOF mass spectrometry-based method for the prediction of antibiotic resistance was described. We evaluated this method for detecting nonsusceptibility against two ß-lactam and two non-ß-lactam antibiotics. A collection of 30 spiked blood cultures was tested for nonsusceptibility against gentamicin and ciprofloxacin. Furthermore, 99 patient-derived blood cultures were tested for nonsusceptibility against cefotaxime, piperacillin-tazobactam, and ciprofloxacin in parallel with MALDI-TOF mass spectrometry identification from the blood culture fluid. The assay correctly classified all isolates tested for nonsusceptibility against gentamicin and cefotaxime. One misclassification for ciprofloxacin nonsusceptibility and five misclassifications for piperacillin-tazobactam nonsusceptibility occurred. Identification of the bacterium and prediction of nonsusceptibility was possible within approximately 4 h.


Assuntos
Hemocultura , Testes de Sensibilidade Microbiana/métodos , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos , Antibacterianos/farmacologia , Erros de Diagnóstico , Farmacorresistência Bacteriana , Humanos , Fatores de Tempo
3.
Parkinsonism Relat Disord ; 28: 100-6, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27158122

RESUMO

BACKGROUND: It is still controversially discussed whether central dopaminergic stimulation improves swallowing ability in Parkinson's disease (PD). We evaluated the effect of oral levodopa application on dysphagia in advanced PD patients with motor fluctuations. METHODS: In 15 PD patients (mean age 71.93 ± 8.29 years, mean disease duration 14.33 ± 5.94 years) with oropharyngeal dysphagia and motor fluctuations endoscopic swallowing evaluation was performed in the off state and on state condition following a specifically developed protocol (FEES-levodopa-test). The respective dysphagia score covered three salient parameters, i. e. premature spillage, penetration/aspiration events and residues, each tested with liquid as well as semisolid and solid food consistencies. An improvement of >30% in this score indicated levodopa responsiveness of dysphagia. Measures were compared between the off- and on-state condition by using the Wilcoxon Test and marginal homogeneity test. Inter- and intrarater reliability was also investigated. RESULTS: Severity of swallowing dysfunction in the off state varied widely. The lowest dysphagia score was 15 points (dysphagia without any aspiration risk). The highest dysphagia score was 84 points (dysphagia with aspiration of all consistencies). Seven patients showed a marked improvement of dysphagia in the on state condition. Eight PD patients did not respond. Inter- and intrarater reliability was excellent for all three subscales in the off state and on state conditions. CONCLUSIONS: A significant proportion of advanced PD patients with motor fluctuations and mild to moderate oropharyngeal dysphagia may demonstrate a clinically relevant improvement of swallowing after levodopa challenge. The FEES-levodopa-test is a reliable and sensitive tool to differentiate these responders from non-responders.


Assuntos
Antiparkinsonianos/farmacologia , Transtornos de Deglutição/tratamento farmacológico , Levodopa/farmacologia , Doença de Parkinson/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Antiparkinsonianos/administração & dosagem , Transtornos de Deglutição/etiologia , Humanos , Levodopa/administração & dosagem , Pessoa de Meia-Idade , Doença de Parkinson/complicações
4.
Intensive Care Med ; 41(9): 1629-37, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26077087

RESUMO

PURPOSE: Treatment of post-stroke dysphagia is notoriously difficult with different neurostimulation strategies having been employed with a variable degree of success. Recently, electrical pharyngeal stimulation (EPS) has been shown to improve swallowing function and in particular decrease airway aspiration in acute stroke. We performed a randomized controlled trial to assess EPS effectiveness on swallowing function in severely dysphagic tracheotomized patients. METHODS: All consecutive stroke patients successfully weaned from the respirator but with severe dysphagia precluding decannulation were screened for eligibility. Eligible patients were randomized to receive either EPS (N = 20) or sham stimulation (N = 10) over three consecutive days. Primary endpoint was ability to decannulate the patient. Swallowing function was assessed using fiberoptic endoscopy. Patients having received sham stimulation were offered EPS treatment during unblinded follow-up if required. Investigators were blinded to the patient's study group allocation. RESULTS: Both groups were well matched for age, stroke severity, and lesion location. Decannulation after study intervention was possible in 75% of patients of the treatment group and in 20% of patients of the sham group (p < 0.01). Secondary outcome parameters did not differ. No adverse events occurred. CONCLUSION: In this pilot study, EPS enhanced remission of dysphagia as assessed with fiberoptic endoscopic evaluation of swallowing (FEES), thereby enabling decannulation in 75% of patients.


Assuntos
Transtornos de Deglutição/etiologia , Transtornos de Deglutição/terapia , Terapia por Estimulação Elétrica , Acidente Vascular Cerebral/complicações , Traqueotomia , Idoso , Terapia por Estimulação Elétrica/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Faringe , Método Simples-Cego
7.
Crit Care Med ; 41(7): 1728-32, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23774336

RESUMO

OBJECTIVES: Decisions regarding tracheostomy tube removal after mechanical ventilation often depend on the physician's individual experience because evidence-based practice guidelines are still scarce, especially for critically ill neurologic patients. In these patients, the prevalence of aspiration is high and regarded as an important contributor to decannulation failure. The presence of severe neurological deficits may, however, give clinicians the subjective impression that a tracheostomy tube is still necessary although decannulation may actually be safe. It is therefore crucial to test swallowing function reliably prior to decannulation in this patient population. DESIGN: Prospective observational study. SETTING: University hospital, neurological ICU. PATIENTS: One hundred tracheostomized patients with acute neurologic disease completely weaned from mechanical ventilation. INTERVENTIONS: An endoscopic protocol evaluating readiness for decannulation and a conventional clinical swallowing examination were carried out by separate, experienced practitioners blinded to each other's decisions. Patient management always followed the decision made with endoscopy. MEASUREMENTS AND MAIN RESULTS: Practitioners' decannulation decisions (yes/no) reached with both assessments were compared. Decannulated patients were monitored throughout their stay for complications related to tube removal. Endoscopy was performed successfully in all subjects without any complications. Following the protocol, the tracheostomy tube was successfully removed in 54 patients, whereas according to the clinical swallowing examination, only 29 patients would have been decannulated at that point. Only one patient needed recannulation due to respiratory problems, resulting in a failure rate of 1.9%. CONCLUSIONS: In neurologic patients, speech-language pathologists' impressions about the patient's state when clinically assessing indirect variables of swallowing function often lead to the unnecessary prolongation of cannulation time. Endoscopic evaluation has the advantage of objectively visualizing the patient's ability to manage secretions directly and allows for faster but, nonetheless, safe decannulation. The endoscopic protocol proposed here is a safe, efficient, and objective bedside tool to guide decannulation decisions.


Assuntos
Protocolos Clínicos , Deglutição , Remoção de Dispositivo/métodos , Respiração Artificial/métodos , Traqueostomia/métodos , Adulto , Idoso , Feminino , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso , Estudos Prospectivos , Patologia da Fala e Linguagem
8.
J Neurol ; 259(1): 93-9, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21647725

RESUMO

Dysphagia is found in up to 80% of acute stroke patients. To date most studies have focused on ischemic stroke only. Little is known about the incidence and pattern of dysphagia in hemorrhagic stroke. Here we describe the characteristics of dysphagia in patients with striatocapsular hemorrhage. Fiberoptic Endoscopic Evaluation of Swallowing (FEES) was carried out in 30 patients with acute striatocapsular hemorrhage. Dysphagia was classified according to the six-point Fiberoptic Endoscopic Dysphagia Severity Scale (FEDSS) within 72 h after admission. Lesion volume, hemisphere and occurrence of ventricular rupture were determined from computer tomography scans. Data on initial NIH-SS, clinical symptoms, need for endotracheal intubation, diagnosis of pneumonia and feeding status on discharge were recorded. Swallowing impairment was observed in 76.7% of patients (n = 23). Mean FEDSS score was 3.1 ± 1.5. Main findings were penetration or aspiration of liquids as well as leakage to valleculae and piriform sinus. Incidence of pneumonia was 30.0% (n = 9). Age, NIH-SS and hematoma volume did not correlate with dysphagia severity. None of the clinical characteristics was predictive for dysphagia. On discharge after 12.9 ± 5.3 days, a two-point improvement on the FEDSS was seen in seven patients, (30.4%) and five patients (21.7%) had gained at least one point. In striatocapsular hemorrhage, dysphagia is a common and so far underrecognized symptom. FEES results indicate predominant impairment of oral motor control. Swallowing impairment is not related to other clinical deficits, stroke severity or lesion characteristics. Thus, detailed dysphagia assessment is indicated in all cases.


Assuntos
Corpo Estriado/patologia , Transtornos de Deglutição/etiologia , Cápsula Interna/patologia , Hemorragias Intracranianas/complicações , Acidente Vascular Cerebral/complicações , Idoso , Ventrículos Cerebrais/patologia , Interpretação Estatística de Dados , Deglutição , Feminino , Lateralidade Funcional , Humanos , Masculino , Pessoa de Meia-Idade , Neuroendoscopia , Fibras Ópticas , Nutrição Parenteral , Pneumonia/complicações , Valor Preditivo dos Testes , Prognóstico , Acidente Vascular Cerebral/etiologia , Reabilitação do Acidente Vascular Cerebral , Tomografia Computadorizada por Raios X
9.
Mov Disord ; 25(9): 1239-45, 2010 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-20629130

RESUMO

Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES) has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 +/- 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L-dopa challenge. Chin tuck-maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients.


Assuntos
Antiparkinsonianos/uso terapêutico , Transtornos de Deglutição , Endoscopia/métodos , Levodopa/uso terapêutico , Idoso , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/tratamento farmacológico , Transtornos de Deglutição/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estatística como Assunto , Estatísticas não Paramétricas , Paralisia Supranuclear Progressiva/complicações , Paralisia Supranuclear Progressiva/tratamento farmacológico
10.
Neuromuscul Disord ; 19(10): 704-8, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19616433

RESUMO

Dysphagia in X-linked bulbospinal muscular atrophy (Kennedy disease) has never been characterized in detail by objective swallowing studies. We assessed the nature of swallowing impairment in Kennedy disease by undertaking fiberoptic endoscopic evaluation of swallowing examinations of 10 genetically confirmed patients with Kennedy disease who were scored according to an ordinal rating scale including 25 different items. The results were compared to an age-matched control group of 10 healthy volunteers. Swallowing dysfunction was found in 80% of patients with Kennedy disease. The main pattern of dysphagia was an incomplete food bolus clearance through the pharynx with residues left in the valleculae overflowing into the laryngeal vestibule after the swallow. Total duration of the pharyngeal swallow was significantly shorter in patients with Kennedy disease compared to the control group. These findings suggest that dysphagia in Kennedy disease is predominantly characterized by an impairment of the pharyngeal phase of swallowing resulting from reduced base-of-tongue movement and bilateral paresis of pharyngeal and laryngeal muscles.


Assuntos
Atrofia Bulboespinal Ligada ao X/epidemiologia , Transtornos de Deglutição/epidemiologia , Adulto , Idoso , Fenômenos Biomecânicos , Atrofia Bulboespinal Ligada ao X/fisiopatologia , Deglutição/fisiologia , Transtornos de Deglutição/fisiopatologia , Humanos , Laringe/fisiopatologia , Masculino , Pessoa de Meia-Idade , Músculos Faríngeos/fisiologia , Reprodutibilidade dos Testes , Índice de Gravidade de Doença , Fatores de Tempo , Língua/fisiopatologia
11.
BMC Med Educ ; 9: 13, 2009 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-19284543

RESUMO

BACKGROUND: Dysphagia is common after stroke. Fiberoptic endoscopic evaluation of swallowing (FEES) is a powerful tool for dysphagia assessment. The purpose of this study was to assess whether a previously established endoscopic examination protocol based on the identification of typical findings indicative of stroke - related dysphagia may be learned and adopted by clinicians so far inexperienced in this field. METHODS: After receiving a structured lecture on this topic, participants were asked to rate video sequences of endoscopic swallowing examinations of acute stroke patients. The first part of the testing ("single findings-rating") comprised of 16 single sequences, the second part ("complete examination-rating") presented the key sequences of 8 complete examinations. Before the second part was started, results of the first were discussed. RESULTS: At the "single findings-rating" 88.8% of video-sequences were assessed correctly, while at the "complete examination-rating" the average performance had improved to 96%. Furthermore, no overlooking of relevant pathologies was noted in the second part of the testing. CONCLUSION: This study suggests that the presented endoscopic examination protocol is reliably interpreted by inexperienced clinicians after a short lecture and may therefore easily and successfully be adopted in dysphagia management of acute stroke care.


Assuntos
Protocolos Clínicos , Transtornos de Deglutição/diagnóstico , Deglutição/fisiologia , Endoscopia/educação , Tecnologia de Fibra Óptica , Neurologia/educação , Aspiração Respiratória/diagnóstico , Acidente Vascular Cerebral/complicações , Adulto , Competência Clínica , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/fisiopatologia , Avaliação Educacional/métodos , Endoscopia/métodos , Endoscopia/normas , Feminino , Humanos , Laringoscopia/métodos , Laringoscopia/normas , Masculino , Neurologia/normas , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Aspiração Respiratória/etiologia , Aspiração Respiratória/fisiopatologia , Saliva/metabolismo , Acidente Vascular Cerebral/fisiopatologia , Gravação em Vídeo
12.
Stroke ; 40(2): 482-6, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19074481

RESUMO

BACKGROUND AND PURPOSE: Fiberoptic endoscopic evaluation of swallowing (FEES) is an excellent method for the accurate examination of swallowing function in the acute phase of stroke. The present study investigates the safety of FEES related to patients characteristics in a setting of acute stroke care. METHODS: A prospective study of FEES-associated complications was carried out in 300 acute stroke patients over a 1-year period. A neurologist and a speech-language pathologist of the stroke unit team performed FEES within a mean time interval of 1.9+/-0.8 days after stroke onset. A closely meshed monitoring of cardiovascular parameters was done during each examination. A discomfort rating was obtained from the patients. RESULTS: In none of the 300 subjects any airway comprise, decrease in the level of consciousness, symptomatic bradycardia/tachycardia, laryngospasm, or epistaxis requiring special treatment was observed. The incidence of self-limiting nosebleeds was 6% and did not significantly differ in relation to major stroke types (ischemic versus hemorrhagic), acute treatment strategy (thrombolysis versus no thrombolysis), or secondary prevention regime (anticoagulant therapy versus antiplatelet drugs). Whereas no alterations in diastolic blood pressure were noted, statistically significant changes in systolic blood pressure, heart rate, and oxygen saturation occurred. However, these alterations did not cause any severe adverse event and were clinically judged as being mild. The assessment of comfort revealed an excellent tolerance of FEES in >80% of patients. CONCLUSIONS: This study demonstrates that FEES is a well-tolerated and safe method to assess swallowing function when performed by a speech-language pathologist and a neurologist in a stroke unit setting.


Assuntos
Deglutição/fisiologia , Tecnologia de Fibra Óptica , Laringoscopia/efeitos adversos , Acidente Vascular Cerebral/fisiopatologia , Doença Aguda , Idoso , Pressão Sanguínea/fisiologia , Isquemia Encefálica/complicações , Hemorragia Cerebral/complicações , Interpretação Estatística de Dados , Epistaxe/etiologia , Feminino , Frequência Cardíaca/fisiologia , Humanos , Laringoscópios , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Acidente Vascular Cerebral/diagnóstico
13.
BMC Neurol ; 8: 28, 2008 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-18651972

RESUMO

BACKGROUND: Early feeding via a nasogastric tube (NGT) is recommended as safe way of supplying nutrition in patients with acute dysphagic stroke. However, preliminary evidence suggests that NGTs themselves may interfere with swallowing physiology. In the present study we therefore investigated the impact of NGTs on swallowing function in acute stroke patients. METHODS: In the first part of the study the incidence and consequences of pharyngeal misplacement of NGTs were examined in 100 stroke patients by fiberoptic endoscopic evaluation of swallowing (FEES). In the second part, the effect of correctly placed NGTs on swallowing function was evaluated by serially examining 25 individual patients with and without a NGT in place. RESULTS: A correctly placed NGT did not cause a worsening of stroke-related dysphagia. Except for two cases, in which swallowing material got stuck to the NGT and penetrated into the laryngeal vestibule after the swallow, no changes of the amount of penetration and aspiration were noted with the NGT in place as compared to the no-tube condition. Pharyngeal misplacement of the NGT was identified in 5 of 100 patients. All these patients showed worsening of dysphagia caused by the malpositioned NGT with an increase of pre-, intra-, and postdeglutitive penetration. CONCLUSION: Based on these findings, there are no principle obstacles to start limited and supervised oral feeding in stroke patients with a NGT in place.


Assuntos
Transtornos de Deglutição/fisiopatologia , Nutrição Enteral/efeitos adversos , Intubação Gastrointestinal/efeitos adversos , Acidente Vascular Cerebral/complicações , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Deglutição/fisiologia , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/etiologia , Endoscopia Gastrointestinal/métodos , Nutrição Enteral/instrumentação , Nutrição Enteral/métodos , Feminino , Alemanha/epidemiologia , Humanos , Incidência , Intubação Gastrointestinal/métodos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/terapia , Resultado do Tratamento
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