RESUMO
Diabetes mellitus (DM) greatly impacts human health worldwide as over 400 million patients suffer from DM-related symptoms. Type 2 DM accounts for more than 90% of DM and is caused mainly by unhealthy lifestyles, such as high-calorie and high-fat diets. Such undesirable eating habitats induce resistance to insulin resulting in high blood sugar levels that cause induction of various symptoms and complications of DM. Therefore, management of blood sugar levels is important for preventing DM. Our group has recently found that rice (Oryza sativa L.) contains anti-diabetes compounds. Here, we summarize the effect of the bioactive ingredients in rice on preventing type 2 DM.
Assuntos
Diabetes Mellitus Tipo 2/prevenção & controle , Dieta/métodos , Hipoglicemiantes/farmacologia , Oryza/química , Glicemia/efeitos dos fármacos , Humanos , Resistência à InsulinaRESUMO
Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.
Assuntos
Albuminas/farmacologia , Glicemia/efeitos dos fármacos , Fagopyrum/química , Inibidores de Glicosídeo Hidrolases/farmacologia , Hiperglicemia/tratamento farmacológico , Hipoglicemiantes/farmacologia , Proteínas de Plantas/farmacologia , Período Pós-Prandial , alfa-Amilases/antagonistas & inibidores , Albuminas/isolamento & purificação , Animais , Biomarcadores/sangue , Glicemia/metabolismo , Inibidores de Glicosídeo Hidrolases/isolamento & purificação , Humanos , Hiperglicemia/sangue , Hipoglicemiantes/isolamento & purificação , Insulina/sangue , Masculino , Proteínas de Plantas/isolamento & purificação , Estabilidade Proteica , Ratos Wistar , Triticum/química , alfa-Amilases/metabolismoRESUMO
Although neurofibroma is a common soft tissue tumor of the head and neck, neurofibroma of the oropharynx is extremely rare. Here, we report a case of neurofibroma of the palatine tonsil. Magnetic resonance imaging was useful in demonstrating the location of the tumor as well as its well-defined appearance. The present case showed a target sign; the tumor exhibited peripheral hyperintensity and central hypointensity on T2-weighted images, reflecting its characteristic zonal anatomy.
Assuntos
Imageamento por Ressonância Magnética/métodos , Neurofibroma/patologia , Neoplasias Orofaríngeas/patologia , Tonsila Palatina/patologia , Feminino , Humanos , Masculino , Doenças Raras/patologia , Estatística como AssuntoRESUMO
As a first step in developing a new psychophysiological technique to assess mental workload in human-computer interaction (HCI), we recorded event-related brain potentials for visual stimuli triggered by voluntary mouse clicks. Twelve university students clicked a mouse button at their own pace. Each click triggered 1 of 3 alphabetic letters assigned to frequent standard, rare target, and rare nontarget stimuli. Counting target stimuli was required. Both rare stimuli elicited a P3 (P300) wave, the amplitude of which was larger when the stimuli were triggered by mouse clicks than when the same stimuli were presented automatically without mouse clicks. Postmotor potentials associated with clicking were small in amplitude (<2 microV) and did not temporally overlap with the P3. The findings suggest that the P3 can be recorded for a computer's response to the user's intentional action and may be used as a measure of perceptual-central processing resources allocated to the HCI task. Actual or potential applications of this research include the evaluation of the user's attentional state during HCI byrecording brain potentials in the "mouse click" or action-perception paradigm.