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1.
J Pediatr Surg ; 59(2): 240-246, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37980195

RESUMO

AIM OF THE STUDY: The aim of the study is to clarify the clinicopathological and biliary morphological characteristics in reported cases of diverticular congenital biliary dilatation (CBD). METHOD: Using PubMed and the Japan Medical Abstracts Society, articles on possible diverticular CBD were extracted and the clinical pictures examined. We also sought evidence for definitions of diverticular CBD and the associated condition of pancreaticobiliary maljunction (PBM) using the original articles by Alonso-Lej and Todani. The characteristic biliary morphologies of cases with images were also investigated. RESULTS: Analyses of 211 possible cases superficially demonstrated multiple diverticula in 12 (12%) and single diverticulum in 89 (88%), with diverticula located in the upper (n = 38, 38%), middle (n = 32, 32%), or lower (n = 26, 26%) biliary tract in and presence of intra-diverticular stones, PBM, and biliary carcinoma in 23% (n = 18), 39% (n = 25), and 11% (n = 14), respectively. However, evidence defining diverticular CBD or justifying the lack of associated PBM was not demonstrated even in the original articles. Scrutiny of the biliary anatomy in 59 cases with images showed incorrect inclusions of types I or IV-A with an irregular biliary duct wall or dilated cystic duct, periampullary choledochal diverticula, or even solitary biliary cysts. Authentic diverticular CBD, representing the diverticulum connected to the middle of the common bile duct via a thin, patent stalk was seen in only 6 cases. CONCLUSION: Real diverticular CBD appears extremely rare. The lack of an objective definition allows wide interpretations of clinical pictures, creating inconsistencies in the diagnosis and treatment of CBD and raising questions regarding the utility of conventional classifications. LEVEL OF EVIDENCE: Level III.


Assuntos
Sistema Biliar , Cisto do Colédoco , Divertículo , Humanos , Cisto do Colédoco/diagnóstico por imagem , Cisto do Colédoco/cirurgia , Ductos Pancreáticos , Ducto Colédoco/diagnóstico por imagem
2.
Pediatr Gastroenterol Hepatol Nutr ; 23(6): 531-538, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33215024

RESUMO

PURPOSE: Our aim was the longitudinal assessment of cyst size in fetuses with biliary cystic malformation (BCM) to explore its etiology and the possibility of antenatal differentiation between biliary atresia (BA) and congenital biliary dilatation (CBD). METHODS: We conducted a retrospective review of all patients diagnosed antenatally with BCM from 1994 to 2014 at our institutions. RESULTS: The study cohort comprised of three patients with BA and six with CBD. There were no significant differences in the gestational age and cyst size at the first detection of BCM between the two groups. In fetuses with CBD, the cyst size steadily increased as the gestational age advanced, while it fluctuated around 1.5 cm and remained below 2.1 cm in those with BA. However, the ratio of cystic area to fetal trunk area was approximately constant due to linear fetal growth in fetuses with CBD. CONCLUSION: Fetuses with BCM <2.1 cm in the late gestation period were more likely to have BA than CBD. Our observation of cyst enlargement with advancing gestational age in the CBD group was attributed solely to fetal growth. Biliary dilatation in fetuses with CBD and BA might be completed at the onset of BCM.

3.
World J Pediatr Surg ; 2(1): e000031, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-38899120

RESUMO

Background: We previously reported a pilot study of temporary umbilical loop colostomy for neonates with intermediate-type anorectal malformations (ARM) and recommended this technique because of its cosmetic excellence. We herein report the postoperative complications of umbilical stomas (US) compared with traditional abdominal stomas (AS). Methods: From our institutional prospective database, we analyzed the patients with ARMs who underwent stoma creation at Kansai Medical University Hospital from January 1995 to November 2016. The surgical technique used to create the US had been performed since 2004. Results: US and AS were made for 12 and 27 patients with ARMs, respectively. The postoperative complication rates in patients who underwent US and AS had no significant difference (17% and 11%, p=0.6). The complications comprised a wound infection (one case of US), ileus (one case each of US and AS), mucosal prolapse (one case of AS), and depression (one case of AS). No emergency surgery was required for these complications. Conclusion: For patients with ARMs, the umbilicus appears to be a safe alternative site for temporary loop colostomy.

4.
Pediatr Int ; 60(5): 400-410, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29878629

RESUMO

BACKGROUND: Despite the presence of ganglion cells in the rectum, some patients have symptoms similar to those of Hirschsprung's disease. A consensus has yet to be established regarding the terminology for these diseases. We defined this group of diseases as "allied disorders of Hirschsprung's disease" and compiled these guidelines to facilitate accurate clinician diagnosis and provide appropriate treatment strategies for each disease. METHODS: These guidelines were developed using the methodologies in the Medical Information Network Distribution System (MINDS). Of seven allied disorders, isolated hypoganglionosis; megacystis-microcolon-intestinal hypoperistalsis syndrome; and chronic idiopathic intestinal pseudo-obstruction were selected as targets of clinical questions (CQ). In a comprehensive search of the Japanese- and English-language articles in PubMed and Ichu-Shi Web, 836 pieces of evidence related to the CQ were extracted from 288 articles; these pieces of evidence were summarized in an evidence table. RESULTS: We herein outline the newly established Japanese clinical practice guidelines for allied disorders of Hirschsprung's disease. Given that the target diseases are rare and intractable, most evidence was drawn from case reports and case series. In the CQ, the diagnosis, medication, nutritional support, surgical therapy, and prognosis for each disease are given. We emphasize the importance of full-thickness intestinal biopsy specimens for the histopathological evaluation of enteric ganglia. Considering the practicality of the guidelines, the recommendations for each CQ were created with protracted discussions among specialists. CONCLUSIONS: Clinical practice recommendations for allied disorders of Hirschprung's disease are given for each CQ, along with an assessment of the current evidence. We hope that the information will be helpful in daily practice and future studies.


Assuntos
Anormalidades Múltiplas , Colo , Doença de Hirschsprung , Pseudo-Obstrução Intestinal , Bexiga Urinária , Humanos , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/terapia , Colo/anormalidades , Diagnóstico Diferencial , Doença de Hirschsprung/diagnóstico , Doença de Hirschsprung/terapia , Pseudo-Obstrução Intestinal/diagnóstico , Pseudo-Obstrução Intestinal/terapia , Japão , Bexiga Urinária/anormalidades
5.
J Hepatobiliary Pancreat Sci ; 24(8): 449-455, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28639336

RESUMO

BACKGROUND: In 2015, the Committee on Diagnostic Criteria of the Japanese Study Group on Pancreaticobiliary Maljunction (PBM) proposed a classification of PBM into four types: (A) stenotic type, (B) non-stenotic type, (C) dilated channel type, and (D) complex type. To validate this classification and clarify the clinical features of the four types of PBM, a retrospective multicenter study was conducted. METHODS: The study group of 317 children with PBM was divided into the four types of PBM. Clinical features, preoperative complications, operations, and postoperative pancreatic complications were evaluated. RESULTS: All patients underwent excision of the extrahepatic bile duct. In type A, the age was younger and there was a higher incidence of cystic dilatation. Non-dilatation of the common bile duct was frequently seen in type B. Abdominal pain with hyperamylasemia was frequently seen in types B and C. In particular, the incidence of protein plugs and biliary perforation was high in type C (56.1% and 14.3%, respectively). The overall incidence of acute pancreatitis was 7.3%. Pancreatitis after excisional surgery was rare in the children in this study. Two patients with type D (0.6%) developed chronic pancreatitis postoperatively. CONCLUSIONS: This proposed classification is simple and correlates well with clinical features.


Assuntos
Doenças Biliares/classificação , Sistema Biliar/anormalidades , Anormalidades do Sistema Digestório/diagnóstico , Pancreatopatias/classificação , Ductos Pancreáticos/anormalidades , Adolescente , Doenças Biliares/mortalidade , Doenças Biliares/cirurgia , Criança , Pré-Escolar , Colangiopancreatografia Retrógrada Endoscópica/métodos , Estudos de Coortes , Anormalidades do Sistema Digestório/epidemiologia , Anormalidades do Sistema Digestório/cirurgia , Feminino , Humanos , Incidência , Japão/epidemiologia , Masculino , Pancreatopatias/mortalidade , Pancreatopatias/cirurgia , Ductos Pancreáticos/cirurgia , Prognóstico , Estudos Retrospectivos , Medição de Risco , Estatísticas não Paramétricas , Taxa de Sobrevida , Tomografia Computadorizada por Raios X/métodos
6.
J Pediatr Surg ; 52(10): 1621-1624, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28410789

RESUMO

PURPOSE: We examined the clinical significance of duodenogastric regurgitation (DGR) as a late complication in the long-term follow-up after hepaticoduodenostomy (HD) as a reconstruction surgery for congenital biliary dilatation (CBD). METHODS: Seventeen patients with CBD were retrospectively analyzed for late complications (mean follow-up, 16.8 years). All patients had undergone total resection of the extrahepatic bile duct followed by HD. DGR was identified using endoscopic examination, intraluminal bile monitoring, and liver scanning. RESULTS: DGR was found in all 17 patients by endoscopic examination and intraluminal bile monitoring. Fourteen of the 17 (82.4%) patients with DGR had experienced abdominal symptoms since a mean of 6.9 years postoperatively. Liver scanning also revealed apparent DGR in all 14 symptomatic patients. We converted 7 of the 14 patients to hepaticojejunostomy reconstruction at a mean of 13.0 years after the initial excisional surgery. Their symptoms were completely relieved postoperatively. CONCLUSIONS: DGR is an important complication after HD. Examination of patients for the development of DGR is an essential part of long-term follow-up in patients with CBD who have undergone HD as a reconstruction surgery. Conversion surgery is recommended in patients with DGR accompanied by long-term abdominal symptoms. LEVELS OF EVIDENCE: Level IV.


Assuntos
Anastomose Cirúrgica/efeitos adversos , Procedimentos Cirúrgicos do Sistema Biliar/efeitos adversos , Cisto do Colédoco/cirurgia , Refluxo Duodenogástrico/etiologia , Adolescente , Sistema Biliar , Procedimentos Cirúrgicos do Sistema Biliar/métodos , Criança , Dilatação Patológica/cirurgia , Feminino , Humanos , Lactente , Masculino , Adulto Jovem
7.
J Hepatobiliary Pancreat Sci ; 24(1): 1-16, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28111910

RESUMO

Until now, there have been no practical clinical guidelines for congenital biliary dilatation (CBD). In this review article, the Japanese Study Group on Congenital Biliary Dilatation (JSCBD) propose to establish clinical practice guidelines for CBD. Because the evidence-based literature is relatively small, we decided to create guidelines based on the consensus of experts, using the medical literature for reference. A total of 20 clinical questions (CQs) were considered by the members of the editorial committee responsible for the guidelines. The CQs included the distinct aspects of CBD: (1) Concepts and Pathology (three CQs); (2) Diagnosis (six CQs); (3) Pancreaticobiliary Complications (three CQs); Treatments and Prognosis (eight CQs). Each statements and comments for CQs were made by the guidelines committee members. CQs were finally approved after review by members of the editorial committee and the guidelines evaluation board of CBD. These guidelines were created to provide assistance in the clinical practice of CBD management; their contents focus on clinical utility, and they include general information on CBD to make this disease more widely recognized.


Assuntos
Ductos Biliares/anormalidades , Cisto do Colédoco/diagnóstico , Cisto do Colédoco/terapia , Guias de Prática Clínica como Assunto/normas , Doenças Biliares/congênito , Doenças Biliares/diagnóstico , Doenças Biliares/terapia , Dilatação Patológica/diagnóstico , Dilatação Patológica/terapia , Feminino , Humanos , Lactente , Recém-Nascido , Japão , Masculino , Sociedades Médicas/normas
8.
Pediatr Surg Int ; 33(1): 33-41, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27696212

RESUMO

PURPOSE: The purpose of this study is to identify the current clinical features of neonatal gastrointestinal perforation in Japan. METHODS: A questionnaire about cases of neonatal gastrointestinal perforation treated in recent 5 years was sent to participating institutions of the Japanese Society of Pediatric Surgeons (JSPS). RESULTS: Five hundred and thirty-six neonates with gastrointestinal perforation were treated. They consisted of 42 patients with gastric rupture/perforation (GR), 33 patients with intestinal atresia/stenosis (IA), 3 patients with malrotation (ML), 118 patients with necrotizing enterocolitis (NEC), 160 patients with focal intestinal perforation (FIP), 46 patients with meconium-related ileus (MRI), 77 patients with meconium peritonitis (MP), and 57 patients with other conditions. The total mortality rate was 20.5 %. The mortality rates of the patients with GR, IA, ML, NEC, FIP, MRI, and MP were 9.5, 9.1, 0, 33.1, 20.6, 28.2, and 9.1 %, respectively. In 263 cases involving extremely low-birth-weight neonates (ELBW), 108 died (mortality rate 41.1 %). The mortality rates for ELBW with GR, NEC, FIP, MRI, MP, and other conditions were 27.3 % (3/11), 58.5 % (48/82), 21.6 % (24/111), 70.6 % (24/34), 57.1 % (4/7), and 27.8 % (5/18), respectively. CONCLUSIONS: The mortality rates for ELBW decreased from 62.8 % in the previous survey to 41.1 % by the time of this survey.


Assuntos
Perfuração Intestinal/epidemiologia , Vigilância da População , Enterocolite Necrosante/complicações , Feminino , Humanos , Recém-Nascido , Perfuração Intestinal/etiologia , Japão/epidemiologia , Masculino
10.
J Hepatobiliary Pancreat Sci ; 23(6): 342-6, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26996969

RESUMO

BACKGROUND: The Diagnostic Criteria for Pancreaticobiliary Maljunction 2013 were published by the Japanese Study Group on Pancreaticobiliary Maljunction (JSGPM) in 2014. The committee of JSGPM for diagnostic criteria for pancreaticobiliary maljunction has established the standard diameter of the bile duct, and a definition of dilatation of the bile duct was proposed in 2014. METHODS: The committee of JSGPM prepared the diagnostic criteria for congenital biliary dilatation in 2014, and a final revised version was approved in 2015. RESULTS: Congenital biliary dilatation is defined as a congenital malformation involving both local dilatation of the extrahepatic bile duct, including the common bile duct, and pancreaticobiliary maljunction. However, cases associated with intrahepatic bile duct dilatation can also be included. Various kinds of pathological conditions can occur on hepatobiliary systems and pancreas by bile duct dilatation and pancreaticobiliary maljunction. For a diagnosis of congenital biliary dilatation, both abnormal dilatation of the bile duct and pancreaticobiliary maljunction must be evident by either imaging test or anatomical examination. Acquired or secondary dilatation of the bile duct by obstruction due to biliary stones or malignancy should be strictly excluded. CONCLUSION: Diagnostic criteria for congenital biliary dilatation 2015 were established from Japan representing a world first.


Assuntos
Ductos Biliares Intra-Hepáticos/diagnóstico por imagem , Cisto do Colédoco/diagnóstico por imagem , Anormalidades do Sistema Digestório/diagnóstico por imagem , Ductos Pancreáticos/diagnóstico por imagem , Ductos Biliares Intra-Hepáticos/anormalidades , Ductos Biliares Intra-Hepáticos/cirurgia , Procedimentos Cirúrgicos do Sistema Biliar/métodos , Cisto do Colédoco/cirurgia , Anormalidades do Sistema Digestório/cirurgia , Dilatação Patológica/congênito , Dilatação Patológica/diagnóstico por imagem , Dilatação Patológica/cirurgia , Feminino , Humanos , Recém-Nascido , Japão , Imageamento por Ressonância Magnética/métodos , Masculino , Ductos Pancreáticos/anormalidades , Ductos Pancreáticos/cirurgia , Sensibilidade e Especificidade , Ultrassonografia Doppler/métodos
11.
Pediatr Surg Int ; 31(11): 1073-6, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26342490

RESUMO

PURPOSE: To clarify the status of segmental dilatation of the intestine (SD) using a nationwide retrospective cohort survey. METHODS: Supported by the Ministry of Health, Labour and Welfare in Japan, preliminary questionnaires requesting the numbers of SD cases from 2000 to 2009 were sent to 161 Japanese major institutes of pediatric surgery and gastroenterology. We present the results of our analysis of the data from secondary questionnaires. RESULTS: Twenty-eight cases of SD were reported, including 19 males and 9 females. The average gestational age was 30.2 weeks and the average birth weight was 2.319 g. The period of onset was neonatal in 18 cases and infancy in 6 cases, including 7 cases diagnosed prenatally. The dilated segment was ileum in 14 cases and colon in 10 cases, and symptoms included abdominal distention, vomiting, and chronic constipation. Concurrent intestinal malformation such as malrotation, intestinal atresia, and anal atresia were present in 4 cases and 27 of 28 cases were successfully treated by surgical resection. Histologically, abnormal muscle layers were found in three cases and ectopic tissue in two cases. CONCLUSION: We determined the clinical features of SD based on data from 28 cases occurring over 10 years.


Assuntos
Inquéritos Epidemiológicos/estatística & dados numéricos , Enteropatias/epidemiologia , Intestinos/patologia , Distribuição por Idade , Criança , Pré-Escolar , Estudos de Coortes , Dilatação Patológica/epidemiologia , Feminino , Humanos , Lactente , Japão/epidemiologia , Masculino , Estudos Retrospectivos , Inquéritos e Questionários
12.
J Hepatobiliary Pancreat Sci ; 22(1): 68-73, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25234051

RESUMO

BACKGROUND: In the revised diagnostic criteria for pancreaticobiliary maljunction (PBM), PBM can be diagnosed from a long common channel by magnetic resonance cholangiopancreatography (MRCP). However, it is necessary to differentiate from high confluence of pancreaticobiliary ducts (HCPBD) with a relatively long common channel (≥6 mm) and effect of the sphincter in the pancreaticobiliary junction. This multicenter study aimed to explore definite value of the length of an abnormally long common channel, which enables to distinguish PBM from HCPBD on MRCP. METHODS: In 184 PBM patients and 22 HCPBD patients who were diagnosed by direct cholangiography and underwent MRCP, the length of the common channel was measured. RESULTS: The length of the common channel was 16.2 ± 6.9 mm on direct cholangiography and 13.9 ± 6.2 mm on MRCP in PBM patients, and 7.7 ± 1.5 mm and 6.6 ± 1.4 mm in HCPBD patients. The optimal cut off value of the length of the common channel to distinguish PBM from HCPBD was identified to be 9 mm. CONCLUSIONS: Pancreaticobiliary maljunction can be diagnosed from an abnormally long common channel on MRCP, but in cases of the common channel ≤9 mm on MRCP, direct cholangiography is needed to confirm PBM.


Assuntos
Ductos Biliares/patologia , Doenças Biliares/diagnóstico , Colangiopancreatografia por Ressonância Magnética/métodos , Pancreatopatias/diagnóstico , Ductos Pancreáticos/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Estudos Retrospectivos , Adulto Jovem
13.
J Hepatobiliary Pancreat Sci ; 21(3): 159-61, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24307541

RESUMO

Pancreaticobiliary maljunction is a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. The diagnostic criteria for pancreaticobiliary maljunction were proposed in 1987. The committee of The Japanese Study Group on Pancreaticobiliary Maljunction (JSGPM) for diagnostic criteria for pancreaticobiliary maljunction began to revise the diagnostic criteria from 2011 taking recently advanced diagnostic imaging techniques into consideration, and the final revised version was approved in the 36(th) Annual Meeting of JSPBM. For diagnosis of pancreaticobiliary maljunction, an abnormally long common channel and/or an abnormal union between the pancreatic and bile ducts must be evident on direct cholangiography, such as endoscopic retrograde cholangiopancreatography, percutaneous transpehatic cholangiography, or intraoperative cholangiography; magnetic resonance cholangiopancreatography; or three-dimensional drip infusion cholangiography computed tomography. However, in cases with a relatively short common channel, it is necessary to confirm that the effect of the papillary sphincter does not extend to the junction by direct cholangiography. Pancreaticobiliary maljunction can be diagnosed also by endoscopic ultrasonography or multi-planar reconstruction images provided by multi-detector row computed tomography. Elevated amylase levels in bile and extrahepatic bile duct dilatation strongly suggest the existence of pancreaticobiliary maljunction.


Assuntos
Ductos Biliares Extra-Hepáticos/anormalidades , Anormalidades do Sistema Digestório/diagnóstico , Ductos Pancreáticos/anormalidades , Humanos
14.
J Gastroenterol ; 49(5): 875-81, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-23736796

RESUMO

BACKGROUND: Pancreatobiliary reflux (PBR) can occur in individuals without pancreaticobiliary maljunction. The aim of this study was to elucidate the incidence of PBR in individuals with a normal pancreaticobiliary junction and its impact on the biliary tree. METHODS: Data were prospectively collected from 15 centers on 420 patients with a morphologically normal pancreaticobiliary junction who had undergone bile sampling and measurement of the biliary amylase level. We investigated the incidence and predictive factors for high biliary amylase levels (HBAL), as well as the relationship of HBAL with biliary malignancy. RESULTS: Twenty-three patients (5.5%) showed HBAL (≥10,000 IU/L). Univariate analysis showed that risk factors for the elevation of biliary amylase levels were the existence of a relatively long common channel (≥5 mm), acute pancreatitis, and papillitis. Multivariate analysis revealed that only the existence of a relatively long common channel was a significant factor for PBR. Biliary amylase levels in patients with a relatively long common channel were significantly higher than in patients without a long common channel (12,333 vs. 2,070 IU/L, P = 0.001). The incidence of HBAL (P < 0.001), as well as the overall biliary amylase levels (P = 0.007) were significantly higher in patients with gallbladder cancer than in those without gallbladder cancer. CONCLUSIONS: The PBR was frequently observed in individuals with a relatively long common channel. Patients showing HBAL with normal pancreaticobiliary junction are at high risk for gallbladder cancer.


Assuntos
Refluxo Biliar/fisiopatologia , Doenças da Vesícula Biliar/fisiopatologia , Neoplasias da Vesícula Biliar/epidemiologia , Pancreatopatias/fisiopatologia , Idoso , Amilases/metabolismo , Bile/metabolismo , Ductos Biliares/anormalidades , Ductos Biliares/anatomia & histologia , Refluxo Biliar/epidemiologia , Ducto Colédoco/anormalidades , Feminino , Doenças da Vesícula Biliar/epidemiologia , Neoplasias da Vesícula Biliar/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Pancreatopatias/epidemiologia , Ductos Pancreáticos/anatomia & histologia , Estudos Prospectivos
15.
J Hepatobiliary Pancreat Sci ; 21(2): 87-92, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23798483

RESUMO

Clinical practice guidelines on how to deal with pancreaticobiliary maljunction (PBM) were made in Japan in 2012, representing a world first. Using a narrow definition, congenital biliary dilatation involves only Todani type I (except type Ib) and type IV-A, both of which are accompanied by PBM in almost all cases. Prospective ultrasonographic study revealed that the maximum diameter of the common bile duct increased with age. Pathophysiological conditions due to pancreatobiliary reflux occur in patients with high confluence of the pancreaticobiliary ducts, a common channel ≥ 6 mm long and occlusion of communication during contraction of the sphincter of Oddi. Since PBM can be diagnosed by magnetic resonance cholangiopancreatography, multi-planar reconstruction multi-detector row computed tomography and endoscopic ultrasonography, the current diagnostic criteria should be revised to take these diagnostic imaging modalities into consideration. According to a nationwide survey, biliary cancer occurred in 21.6% of adult patients with PBM with biliary dilatation and 42.2% of patients with PBM without biliary dilatation. In biliary cancer associated with PBM without biliary dilatation, 88.1% were gallbladder cancer. Treatment for PBM with biliary dilatation is prophylactic flow-diversion surgery, but further investigations and surveillance studies are needed to clarify the appropriate surgical strategy for PBM without biliary dilatation.


Assuntos
Ductos Biliares/anormalidades , Ductos Pancreáticos/anormalidades , Adulto , Neoplasias dos Ductos Biliares/etiologia , Ductos Biliares/diagnóstico por imagem , Neoplasias do Sistema Biliar/diagnóstico , Criança , Dilatação Patológica , Retroalimentação , Humanos , Ductos Pancreáticos/diagnóstico por imagem , Guias de Prática Clínica como Assunto , Ultrassonografia
16.
J Gastroenterol ; 48(9): 1045-50, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23128976

RESUMO

BACKGROUND: In adults, less than 10-mm bile duct has idiomatically been recognized as "non-dilated bile duct" though there was no obvious evidence. The aim of this study was to prospectively examine the maximum inner diameter of extrahepatic bile duct (MDEBD) in consecutive adults. METHODS: Transabdominal ultrasound (US) was performed to measure the MDEBD of 8840 cases (4420 male) in five institutions. The frequency of ultrasound probe ranged from 3.5 to 5 MHz. RESULTS: The mean diameter of MDEBD was 4.5 ± 1.4 mm (range 1-14 mm). The relationship between the MDEBD and age was shown as follows: MDEBD = 2.83 + 0.03 × age. Multiple regression analysis was analyzed between 6 groups and significant α level is 0.008 in this analysis. In all age groups but 20s and 30s, there was statistically significant MDEBD among each age group (p < 0.0001). Mean, mode value and median MDEBD is increasing according to the age as follows: 20s: 3.9 ± 1.0 mm, 30s: 3.9 ± 1.2 mm, 40s: 4.3 ± 1.2 mm, 50s: 4.6 ± 1.3 mm, 60s: 4.9 ± 1.4 mm, >70s: 5.3 ± 1.6 mm. CONCLUSION: The present study revealed that MDEBD positively correlates with age. Therefore, when we examine the presence of dilation of the bile duct, our calculating formula appears to be suitable for accurate evaluation.


Assuntos
Ductos Biliares Extra-Hepáticos/anatomia & histologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/patologia , Ductos Biliares Extra-Hepáticos/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Valores de Referência , Caracteres Sexuais , Ultrassonografia , Adulto Jovem
17.
Pediatr Surg Int ; 28(11): 1133-6, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23001137

RESUMO

Transumbilical surgical procedures have been reported to be a feasible, safe, and cosmetically excellent procedure for various pediatric surgical diseases. Umbilical loop colostomies have previously been created in patients with Hirschsprung's disease, but not in patients with anorectal malformations (ARMs). We assessed the feasibility and cosmetic results of temporal umbilical loop colostomy (TULC) in patients with ARMs. A circumferential skin incision was made at the base of the umbilical cord under general anesthesia. The skin, subcutaneous tissue, and fascia were cored out vertically, and the umbilical vessels and urachal remnant were individually ligated apart from the opening in the fascia. A loop colostomy was created in double-barreled fashion with a high chimney more than 2 cm above the level of the skin. The final size of the opening in the skin and fascia was modified according to the size of the bowel. The bowel wall was fixed separately to the peritoneum and fascia with interrupted 5-0 absorbable sutures. The bowel was opened longitudinally and everted without suturing to the skin. The loop was divided 7 days postoperatively, and diversion of the oral bowel was completed. The colostomy was closed 2-3 months after posterior saggital anorectoplasty through a peristomal skin incision followed by end-to-end anastomosis. Final wound closure was performed in a semi-opened fashion to create a deep umbilicus. TULCs were successfully created in seven infants with rectourethral bulbar fistula or rectovestibular fistula. Postoperative complications included mucosal prolapse in one case. No wound infection or spontaneous umbilical ring narrowing was observed. Skin problems were minimal, and stoma care could easily be performed by attaching stoma bag. Healing of umbilical wounds after TULC closure was excellent. The umbilicus may be an alternative stoma site for temporary loop colostomy in infants with intermediate-type anorectal malformations, who undergo radical anorectoplasty via a non-abdominal approach.


Assuntos
Anormalidades Múltiplas/cirurgia , Canal Anal/anormalidades , Canal Anal/cirurgia , Colostomia/métodos , Reto/anormalidades , Reto/cirurgia , Cordão Umbilical/cirurgia , Estudos de Viabilidade , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Fatores de Tempo
19.
World J Surg Oncol ; 10: 6, 2012 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-22230934

RESUMO

BACKGROUND: Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers. CASE PRESENTATION: We report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body. Their pathological examination showed gastric cancer (poorly differentiated diffuse adenocarcinoma) and GIST (low-risk category). Further, immunohistochemical staining for C-kit and CD34 was positive, while that for SMA and S-100 was negative. CONCLUSION: Although it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and post-operative diagnoses may be essential, and such cancer development is not considered to be unusual.


Assuntos
Adenocarcinoma/complicações , Adenocarcinoma/patologia , Tumores do Estroma Gastrointestinal/complicações , Tumores do Estroma Gastrointestinal/patologia , Neoplasias Primárias Múltiplas/etiologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Gástricas/complicações , Neoplasias Gástricas/patologia , Adenocarcinoma/cirurgia , Antígenos CD34/análise , Tumores do Estroma Gastrointestinal/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/cirurgia , Prognóstico , Neoplasias Gástricas/cirurgia
20.
Gan To Kagaku Ryoho ; 37(8): 1497-501, 2010 Aug.
Artigo em Japonês | MEDLINE | ID: mdl-20716874

RESUMO

BACKGROUND: This study aimed to compare the surgical outcome and long-term survival between simultaneous and delayed resection of liver metastases from colorectal cancer (LM). METHODS: Seventy-four patients with LM were divided into two groups, i. e., 32 patients who underwent hepatectomy at the time of colorectal surgery (simultaneous group) and 35 patients who underwent delayed liver resection (delayed group). RESULTS: In 12 of the 35 (34%) patients from the delayed group, new metastatic lesions were found in the same and/or different segments after re-evaluation during the interval between operations. These patients had a shorter interval between procedures, and larger tumors than patients without tumor progression. There were significant differences (p=0.0454 and 0.0077) of hepatic disease-free survival between the metachronous or delayed groups and the simultaneous group. Multivariate analysis showed that simultaneous resection was one of three independent prognostic indicators with an influence on hepatic disease-free survival. CONCLUSIONS: Tumor progression could be recognized and occult metastases were detected during the interval between operations. Delayed resection of synchronous LM may be useful to reduce the risk of rapid recurrence in the remnant liver.


Assuntos
Neoplasias Colorretais/patologia , Neoplasias Hepáticas/cirurgia , Idoso , Neoplasias Colorretais/cirurgia , Feminino , Hepatectomia , Humanos , Neoplasias Hepáticas/secundário , Masculino , Pessoa de Meia-Idade , Prognóstico , Taxa de Sobrevida
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