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2.
Ultrasound Obstet Gynecol ; 44(6): 682-7, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24604577

RESUMO

OBJECTIVES: To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to determine whether the distance between the left atrium and the descending aorta would be useful in the prenatal diagnosis of fetal TAPVC. METHODS: We reviewed the fetal echocardiograms of eight cases of TAPVC (five supracardiac type and three infracardiac type) with no other cardiac malformations. We evaluated the ratio of the left atrium-descending aorta distance to the diameter of the descending aorta ('post-LA space index') in 101 normal and eight TAPVC fetuses, and compared the values between groups. In addition, we examined the tricuspid valve/mitral valve diameter ratio (TVD/MVD) and the right ventricular end-diastolic diameter/left ventricular end-diastolic diameter ratio (RVDd/LVDd). RESULTS: The echocardiograms for fetuses with TAPVC and normal fetuses were performed at mean gestational ages of 27.5 weeks and 29.6 weeks, respectively. There were no significant differences in the TVD/MVD and RVDd/LVDd ratios between the groups. However, the post-LA space index was significantly higher in the TAPVC cases (mean, 1.51) than it was in the normal fetuses (mean, 0.71 ± 0.23) (P < 0.0001). On an analysis of the receiver-operating characteristics curve, a post-LA space index cut-off of 1.27 was found to be optimal for distinguishing between TAPVC and normal hearts, with a sensitivity of 100% and specificity of 99%. CONCLUSIONS: The novel post-LA space index could potentially be used for the prenatal diagnosis of TAPVC. A diagnosis of TAPVC is very likely in cases with a post-LA space index of > 1.27.


Assuntos
Síndrome de Cimitarra/diagnóstico por imagem , Ultrassonografia Pré-Natal , Aorta Torácica/diagnóstico por imagem , Aorta Torácica/embriologia , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/embriologia , Valvas Cardíacas/diagnóstico por imagem , Valvas Cardíacas/embriologia , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/embriologia , Humanos , Gravidez , Terceiro Trimestre da Gravidez , Curva ROC , Estudos Retrospectivos
3.
Kyobu Geka ; 61(4): 303-9, 2008 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-18411694

RESUMO

We assessed the effect of reconstructing the pulmonary artery during arterial switch surgery for transposition of the great arteries on late pulmonary stenosis. Sixty-five patients who underwent Lecompte procedure between September 1991 and December 2006 were divided, by the procedure used chronologically to reconstruct the pulmonary artery, into group XP (single pantaloon patch with equine pericardium, n = 11), group P (direct reconstruction, n = 47), and group AP (single pantaloon patch with fresh autopericardium, n = 7). Outcome and pulmonary stenosis on the most recent ultrasound cardiography (UCG) were compared in the 3 groups. The median follow-up was 13, 7.5, and 1.3 years, respectively. Both early and late mortalities were 1.5% (1/65). Although percutaneous trans-pulmonary angioplasty was necessary in 1, 13, and 3 patients, there was 1, 1, and 0 reoperation for pulmonary stenosis in the 3 groups, respectively. Pulmonary stenosis (pulmonary arterial maximum flow velocity > 3 m/sec on UCG) was present in 4 (40%). 14 (30%). and 3 patients (43%). Although there was no significant difference among the 3 procedures in preventing pulmonary stenosis 10 years after arterial switch surgery, direct reconstruction of the pulmonary artery may show a superior outcome, in particular, over 10 years after arterial switch surgery.


Assuntos
Procedimentos Cirúrgicos Cardíacos/métodos , Artéria Pulmonar/cirurgia , Transposição dos Grandes Vasos/cirurgia , Seguimentos , Humanos , Lactente , Recém-Nascido , Estenose da Valva Pulmonar/prevenção & controle
4.
Int J Cardiovasc Imaging ; 17(4): 305-14, 2001 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-11599870

RESUMO

This study was undertaken to evaluate the feasibility of ultrafast computed tomography (CT) and magnetic resonance imaging (MRI) for anatomical and pathophysiological diagnosis of isolated noncompaction of the left ventricular myocardium (INVM) compared with other imaging modalities including thallium myocardial imaging. Six patients, three sets of siblings, ranging in age from 13 to 18 years, were included in this study. Two-dimensional echocardiograms revealed numerous prominent trabeculations and deep intertrabecular recesses in one or more ventricular wall segments in all cases. Thallium-201 myocardial imaging disclosed a hypoperfusion area corresponding to the zones where noncompacted ventricular myocardium was localized. Ultrafast CT showed early defects of varying degrees and rate enhancement of the noncompacted ventricular myocardium, implying fibrosis in this area. MRI disclosed inner zones of noncompacted myocardium distinguishable from thin outer zones of compacted myocardium. T2-weighted imaging revealed high intensity areas at the apex of the left ventricle, suggesting disturbed microcirculation due to fibrosis, thrombus formation, and hypokinesis. Cine MRI revealed hypokinesis of the noncompacted ventricular wall during the cardiac cycle. In conclusion, ultrafast CT and MRI provide high-resolution imaging of noncompacted myocardium, and also pathophysiological details regarding this rare disease.


Assuntos
Cardiomiopatias/diagnóstico , Cardiomiopatias/patologia , Cardiopatias/diagnóstico , Ventrículos do Coração/patologia , Adolescente , Biópsia , Cateterismo Cardíaco , Ecocardiografia Doppler em Cores , Feminino , Cardiopatias/complicações , Humanos , Aumento da Imagem , Japão/epidemiologia , Imageamento por Ressonância Magnética , Masculino , Volume Sistólico/fisiologia , Radioisótopos de Tálio , Tomografia Computadorizada por Raios X , Disfunção Ventricular Esquerda/complicações , Disfunção Ventricular Esquerda/diagnóstico
5.
J Am Soc Echocardiogr ; 14(7): 682-90, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-11447413

RESUMO

Dipyridamole stress integrated backscatter (IBS) was used for evaluation of myocardial ischemia or damage in 31 children with coronary artery lesions caused by Kawasaki disease, in comparison with thallium-201 myocardial imaging. All patients underwent echocardiography at rest and after dipyridamole stress at the anterior interventricular septum, posterior wall (PW), and inferior wall (INF). At rest, no significant difference was seen in cyclic variation (CV) of IBS in the regions with normal or abnormal distribution on Tl-201 imaging. But in the regions showing abnormal distribution after stress, CV decreased significantly. A delayed study after stress showed the recovery of CV to the level at rest in all patients. Sensitivity of abnormal cyclic variation integrated backscatter was 75% in the PW and 91% in the INF, and specificity was 91% in the PW and 90% in the INF, compared with the results of thallium-201 imaging. Dipyridamole stress IBS can provide sensitive detection of myocardial ischemia or damage in Kawasaki disease.


Assuntos
Dipiridamol , Síndrome de Linfonodos Mucocutâneos/diagnóstico por imagem , Isquemia Miocárdica/diagnóstico por imagem , Adolescente , Adulto , Criança , Pré-Escolar , Ecocardiografia/métodos , Feminino , Humanos , Masculino , Síndrome de Linfonodos Mucocutâneos/fisiopatologia , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/fisiopatologia , Sensibilidade e Especificidade , Radioisótopos de Tálio
6.
Pediatr Res ; 49(1): 74-80, 2001 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11134495

RESUMO

Kawasaki disease (KD) is a syndrome of systemic vasculitis of unknown etiology that is complicated by coronary artery lesions (CAL), leading occasionally to cardiac ischemic sequelae. To examine whether vascular endothelial growth factor (VEGF) is responsible for CAL in KD, we determined serum VEGF levels by ELISA and peripheral blood mononuclear cell (PBMC) and neutrophil VEGF expression by immunoblot analysis. Significantly increased levels of VEGF were demonstrated in acute KD as well as in other vasculitis syndromes (p < 0.0001). In the 10 KD patients with CAL, serum VEGF levels were maximal approximately 2 wk post-onset when CAL generally develops and were significantly higher than in 20 patients without CAL (mean, 474 and 241 pg/mL, respectively; p = 0.00015). During the same period, immunoblot analysis revealed maximal VEGF expression in PBMC, corresponding to serum VEGF levels in most patients and being particularly marked in patients with CAL (p < 0.01). Neutrophils expressed VEGF only in the early stage of acute KD and declined rapidly in the majority of KD patients regardless of the presence of CAL, showing a strikingly different expression pattern than that for PBMC. Predominant VEGF expression by PBMC was also demonstrated in patients with other vasculitis syndromes and only faintly in normal controls. The results suggest that VEGF is generated dynamically in KD, presumably reflecting its disease activity. Neutrophil-derived VEGF may play a role in regulating early vascular responses, whereas PBMC-derived VEGF may contribute to later vascular injury and remodeling.


Assuntos
Doença das Coronárias/sangue , Fatores de Crescimento Endotelial/fisiologia , Linfocinas/fisiologia , Monócitos/metabolismo , Síndrome de Linfonodos Mucocutâneos/sangue , Neutrófilos/metabolismo , Adolescente , Western Blotting , Criança , Pré-Escolar , Doença das Coronárias/patologia , Progressão da Doença , Fatores de Crescimento Endotelial/sangue , Citometria de Fluxo , Humanos , Lactente , Recém-Nascido , Linfocinas/sangue , Síndrome de Linfonodos Mucocutâneos/patologia , Fator A de Crescimento do Endotélio Vascular , Fatores de Crescimento do Endotélio Vascular
7.
Cardiol Young ; 10(2): 147-9, 2000 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10817300

RESUMO

A young female athlete is described with anomalous origin of the main stem of the left coronary artery from the non-facing sinus of Valsalva who sustained myocardial infarction and died suddenly after physical exertion. Autopsy findings illustrated the mechanistic importance of acute angle take-off of the left main coronary artery and a slit-like orifice, which was likely compressed and obstructed by acute expansion of the aortic wall. This rare type of coronary anomaly has been regarded as having little clinical significance, but it can lead to sudden cardiac death under physical exertion.


Assuntos
Anomalias dos Vasos Coronários/patologia , Morte Súbita Cardíaca/etiologia , Seio Aórtico/anormalidades , Criança , Morte Súbita Cardíaca/patologia , Feminino , Humanos , Esforço Físico
8.
J Am Coll Cardiol ; 34(1): 233-40, 1999 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10400016

RESUMO

OBJECTIVES: A nationwide survey was conducted to clarify the clinical features of isolated noncompaction of the ventricular myocardium (INVM) in Japanese children in comparison with features previously described in patients with INVM. BACKGROUND: Isolated noncompaction of the ventricular myocardium is a rare disorder characterized by an excessively prominent trabecular meshwork. It is accompanied by depressed ventricular function, systemic embolism and ventricular arrhythmia. METHODS: A questionnaire specifically designed for this study was sent to 150 hospitals in Japan where a pediatric cardiology division exists. RESULTS: Twenty-seven patients were diagnosed by two-dimensional echocardiography, their ages ranging from one week to 15 years at presentation, with follow-up lasting as long as 17 years. The gross anatomical appearance and the extension of noncompacted myocardium predominantly at the apex observed on two-dimensional echocardiograms were similar to observations reported previously. Dissimilarities included a greater number of asymptomatic patients at initial presentation, a longer clinical course with gradually depressed left ventricular function, no systemic embolism, and rare ventricular tachycardia in the Japanese children. Cardiac catheterization disclosed normal left ventricular end-diastolic volume and increased left ventricular end-diastolic pressure in most cases, consistent with restrictive hemodynamics. A higher incidence of Wolff-Parkinson-White syndrome was found in the children, whereas left bundle branch block was rarer than reported in adults. Familial recurrence was high (44%) and included many women. CONCLUSIONS: In Japanese children, INVM can be found by screening examinations at asymptomatic stage, and it might have a longer dinical course with gradually depressed left ventricular function and restrictive hemodynamics. The pattern of familial recurrence we observed implies that INVM is a distinctive clinical entity with a heterogeneous genetic background.


Assuntos
Cardiomiopatias/diagnóstico , Adolescente , Cateterismo Cardíaco , Cardiomiopatias/diagnóstico por imagem , Cardiomiopatias/patologia , Cardiomiopatias/fisiopatologia , Criança , Pré-Escolar , Eletroencefalografia , Feminino , Ventrículos do Coração/patologia , Hemodinâmica , Humanos , Lactente , Recém-Nascido , Japão , Masculino , Miocárdio/patologia , Malha Trabecular/patologia , Resultado do Tratamento , Ultrassonografia , Função Ventricular Esquerda
9.
Circulation ; 99(18): 2367-70, 1999 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-10318655

RESUMO

BACKGROUND: Anthracycline drugs for cancer therapy often cause functional myocardial impairment even in relatively low doses. We investigated the left ventricular function in asymptomatic anthracycline-treated children by automatic border detection (ABD) to assess its clinical usefulness for unmasking latent anthracycline-induced myocardial damage. METHODS AND RESULTS: Thirty-four children (0.7 to 17.6 years old) during or after anthracycline chemotherapy (26 to 1100 mg/m2) for malignancy (Chemo group) were studied, and 40 children (2.8 to 15.6 years old) without cardiac involvement served as normal control subjects (Control group). All patients underwent complete echocardiographic examination, including M-mode, Doppler, and ABD. Conventional echocardiography disclosed no difference between groups with regard to ejection fraction and the ratio of early to late transmitral flow velocity. In marked contrast, an investigation using ABD revealed that the Chemo group appeared to have some anthracycline-induced myocardial damage. In the apical 4-chamber view, peak filling rate in the Chemo group [2.3+/-0.4 end-diastolic area (EDA)/s] was significantly lower than that in the Control group (3.1+/-0.5 EDA/s) (P<0.0001), and time to peak filling rate in the Chemo group (106+/-31 ms) was clearly prolonged compared with that in the Control group (74+/-22 ms) (P<0.0001). CONCLUSIONS: Echocardiographic ABD may be a sensitive and useful noninvasive approach for evaluating subclinical anthracycline cardiotoxicity.


Assuntos
Antibióticos Antineoplásicos/efeitos adversos , Cardiomiopatias/induzido quimicamente , Ecocardiografia/métodos , Neoplasias/tratamento farmacológico , Disfunção Ventricular Esquerda/induzido quimicamente , Adolescente , Cardiomiopatias/diagnóstico por imagem , Criança , Pré-Escolar , Diástole , Estudos de Avaliação como Assunto , Estudos de Viabilidade , Feminino , Neoplasias Hematológicas/complicações , Neoplasias Hematológicas/tratamento farmacológico , Humanos , Processamento de Imagem Assistida por Computador , Lactente , Masculino , Neoplasias/complicações , Sensibilidade e Especificidade , Disfunção Ventricular Esquerda/diagnóstico por imagem , Função Ventricular Esquerda
10.
Pediatr Int ; 41(2): 126-31, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10221013

RESUMO

BACKGROUND: Measurement of left ventricular mass (LVM) is important to the diagnosis of left ventricular hypertrophy in children with various cardiovascular diseases. The purpose of this study was to determine the most appropriate method for standardization of LVM and to evaluate obesity-induced left ventricular hypertrophy in children across the entire age range, from infancy through adolescence. METHODS: We studied 928 children and adolescents (527 males, 401 females), aged 0-17 years, who were classified into two groups by degree of obesity. Left ventricular mass was calculated by M-mode echocardiography using the formula of Devereux et al. and was indexed using body size (body length, bodyweight or body surface area) raised to a non-integer power using logarithmic transformation of measurements in children without obesity. RESULTS: The body length, bodyweight and body surface area exponents were 1.85, 0.88 and 1.15, respectively, in males, and 1.72, 0.82 and 1.08, respectively, in females. Whereas indexing of left ventricular mass by body length both in males and in females revealed significant differences between the two groups, indexing using bodyweight or body surface area exponents did not manifest left ventricular hypertrophy induced by obesity. CONCLUSION: It is suggested that applying body length exponents 1.85 in males and 1.72 in females is an appropriate method for indexation of LVM in children and adolescents. This method is particularly useful for the evaluation of left ventricular hypertrophy in children.


Assuntos
Ecocardiografia/estatística & dados numéricos , Hipertrofia Ventricular Esquerda/diagnóstico por imagem , Obesidade/complicações , Adolescente , Constituição Corporal , Peso Corporal , Criança , Pré-Escolar , Feminino , Ventrículos do Coração/anatomia & histologia , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/patologia , Humanos , Hipertrofia Ventricular Esquerda/etiologia , Lactente , Recém-Nascido , Masculino , Valores de Referência
11.
Int J Card Imaging ; 15(6): 465-71, 1999 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-10768741

RESUMO

The purpose of the study is to determine the feasibility of a novel simplified technique using cine magnetic resonance imaging (MRI) to assess left ventricular (LV) volume and ejection fraction (EF) validated by comparison with biplane LV angiography. Previous MRI studies to assess LV volumes have used multiple axial planes, which are compromised by partial volume effects and are time consuming to acquire and analyze. Accordingly, we developed a simplified imaging approach using biplane cine MRI and imaging planes aligned with the intrinsic cardiac axes of the LV. We studied 20 children (aged 4 months to 10 years) with various heart diseases. The accuracy of cine MRI was compared with that of LV angiography in all patients. LV volumes were calculated using Simpson's rule algorithm, for both MRI and LV angiography. LV volumes determined from MRI were slightly underestimated but correlated reasonably well with angiographic volumes (LVEDV: Y = 0.88X + 1.58, r = 0.99, LVESV: Y = 0.73X + 1.03, r = 0.98). Most importantly, even in patients who had abnormal ventricular curvature such as in tetralogy of Fallot, MRI determined LV volumes correlated well with angiographic values. The MR study was completed within 35 min in all patients. In conclusion, simplified biplane cine MRI, using the intrinsic LV axis planes, permits noninvasive assessment of LV volumes in views comparable to standard angiographic projections and appears practical for clinical use in childhood heart disease since the scan and analysis times are relatively short.


Assuntos
Cineangiografia/métodos , Cardiopatias Congênitas/diagnóstico , Imagem Cinética por Ressonância Magnética/métodos , Volume Sistólico , Função Ventricular Esquerda , Criança , Pré-Escolar , Estudos de Viabilidade , Feminino , Cardiopatias Congênitas/diagnóstico por imagem , Humanos , Lactente , Masculino , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
12.
Int J Card Imaging ; 15(6): 473-81, 1999 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-10768742

RESUMO

The purpose of this study was to assess the capability of multiplanar cine magnetic resonance imaging (MRI) for evaluating pre- and post-operative pulmonary circulation in patients with pulmonary atresia and severe pulmonary stenosis. Seventy-three multiplanar cine MRIs were performed in 30 patients, aged 1 month to 7 years (mean age, 27 months). The morphology and size of the central pulmonary arteries (PA), source of the major aortopulmonary collateral arteries (MAPCA), patency of Blalock-Taussig (BT) shunt vessels, and the post-operative pulmonary circulation were assessed. The accuracy of cine MRI was compared with that of angiography in all patients. The PA was visualized to the first hilar branch in 21 patients, but not in 8 patients in whom the central PA was absent. On follow-up MRI, PA growth was measured, and the results showed excellent correlation with the results obtained by angiography. In 17 patients who had undergone 23 BT shunt operations, cine MRI correctly demonstrated all patient shunts and 5 of 6 stenotic lesions. Multiplanar cine MRI provided excellent detail of the peripheral PA in all patients, 7 of 8 peripheral pulmonary stenoses, 3 of 4 nonconfluent pulmonary arteries, and 2 of 3 PA obstructions. Although the sources of MAPCA were identified in 7 of 9 patients, the distal connection of the MAPCA was not detected in all patients. Seven patients were reexamined after pulmonary plasty; they exhibited normal pulmonary flow patterns. Multiplanar cine MRI provides high-resolution imaging of PA with dynamic visualization of flow and is an effective noninvasive technique for evaluating pre- and post-operative patients with pulmonary atresia and severe pulmonary stenosis.


Assuntos
Imagem Cinética por Ressonância Magnética/métodos , Atresia Pulmonar/diagnóstico , Circulação Pulmonar , Estenose da Valva Pulmonar/diagnóstico , Criança , Pré-Escolar , Estudos de Avaliação como Assunto , Feminino , Seguimentos , Humanos , Aumento da Imagem/métodos , Lactente , Masculino , Monitorização Fisiológica/métodos , Período Pós-Operatório , Atresia Pulmonar/cirurgia , Estenose da Valva Pulmonar/cirurgia , Sensibilidade e Especificidade , Índice de Gravidade de Doença
13.
Acta Paediatr Jpn ; 40(3): 226-31, 1998 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9695294

RESUMO

BACKGROUND: Evaluation of the clinical usefulness of the one-line automatic border detection system for determination of left ventricular volume in children in comparison to the conventional off-line method. METHODS: Eighty consecutive patients in whom clear images were obtained by two-dimensional echocardiography were studied. Using the Hewlett-Packard Sonos 2500 with a 3.5 or 5.5 Mhz phased array transducer, all patients were studied in the apical four-chamber imaging plane for automatic border detection and apical four-chamber and two-chamber imaging planes for manual tracing. Left ventricular end-diastolic and end-systolic volumes were measured and compared using the bi-plane Simpson method. RESULTS: Left ventricular end-diastolic volumes obtained by automatic border detection correlated well but were slightly underestimated compared to those obtained by manual tracing (r = 0.98). Left ventricular end-systolic volumes obtained by automatic border detection also correlated well with those obtained by manual tracing (r = 0.96). Left ventricular ejection fractions compared favorably. However, left ventricular volumes obtained using the classical Pombo M-mode echocardiography showed poorer correlation with those obtained by manual tracing methods. CONCLUSIONS: Automatic border detection is a promising method for real-time estimation of left ventricular volume. In patients with good endocardial tracking, automatic border detection can be used for routine studies of cardiovascular disease, even in children.


Assuntos
Ecocardiografia/instrumentação , Processamento de Sinais Assistido por Computador , Função Ventricular Esquerda/fisiologia , Adolescente , Criança , Pré-Escolar , Feminino , Hemodinâmica , Humanos , Lactente , Modelos Lineares , Masculino
14.
Acta Paediatr Jpn ; 40(1): 14-9, 1998 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9583194

RESUMO

Abnormal biosynthesis of thromboxane and prostacyclin has been implicated in patients with primary pulmonary hypertension and secondary pulmonary hypertension associated with congenital heart disease, and could be involved in the pathogenesis of pulmonary vascular disease. The chronic effects of an oral prostacyclin analogue, beraprost sodium, on thromboxane and prostacyclin biosynthesis and on pulmonary circulation were investigated in 15 children with pulmonary hypertension. The plasma concentrations of thromboxane B2 and 6-keto-prostaglandin F1 alpha were measured, as was the urinary excretion of 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F1 alpha, which are stable metabolites of thromboxane A2 and prostacyclin, respectively. In patients with pulmonary hypertension, the plasma concentration of thromboxane B2 and the ratio of thromboxane B2 to 6-keto-prostaglandin F1 alpha were greater than in healthy controls: 210 +/- 49 versus 28 +/- 4 pg/mL (P < 0.05) and 32.6 +/- 8.9 versus 5.7 +/- 1.8 (P < 0.01), respectively. After 3 months of administration of beraprost, the plasma concentration of thromboxane B2 and the ratio of thromboxane B2 to 6-keto-prostaglandin F1 alpha were reduced significantly: 210 +/- 49 to 98 +/- 26 pg/mL (P < 0.01) and 32.6 +/- 8.9 to 18.0 +/- 6.7 (P < 0.05), respectively. In contrast, the plasma concentrations of 6-keto-prostaglandin F1 alpha in patients were slightly but not significantly higher than in controls, and did not change significantly after administration of beraprost. The concentrations of 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F1 alpha in urine correlated significantly with thromboxane B2 and 6-keto-prostaglandin F1 alpha, respectively, in plasma. Beraprost improved the imbalance of thromboxane and prostacyclin biosynthesis and has a potential efficacy for preventing the progressive development of pathological changes in pulmonary vasculature.


Assuntos
Epoprostenol/análogos & derivados , Epoprostenol/biossíntese , Hipertensão Pulmonar/tratamento farmacológico , Hipertensão Pulmonar/metabolismo , Inibidores da Agregação Plaquetária/farmacologia , Tromboxano A2/biossíntese , Vasodilatadores/farmacologia , Criança , Pré-Escolar , Epoprostenol/farmacologia , Cardiopatias Congênitas/complicações , Cardiopatias Congênitas/metabolismo , Hemodinâmica/efeitos dos fármacos , Humanos , Hipertensão Pulmonar/complicações , Lactente , Prostaglandinas F/metabolismo , Tromboxano B2/metabolismo
15.
Am J Cardiol ; 80(5): 662-4, 1997 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-9295007

RESUMO

Combined administration of inhaled nitric oxide and beraprost sodium resulted in a more intense decrease in pulmonary vascular resistance than nitric oxide given alone (mean -33% vs -45%, p <0.05), without serious systemic hypotension. Combined therapy with nitric oxide and beraprost sodium is highly desirable in treating primary and secondary pulmonary hypertension in children.


Assuntos
Epoprostenol/análogos & derivados , Hipertensão Pulmonar/tratamento farmacológico , Pulmão/fisiologia , Óxido Nítrico/farmacologia , Vasodilatação/efeitos dos fármacos , Vasodilatadores/farmacologia , Criança , Pré-Escolar , AMP Cíclico/sangue , GMP Cíclico/sangue , Sinergismo Farmacológico , Epoprostenol/farmacologia , Humanos , Lactente , Pulmão/efeitos dos fármacos , Resistência Vascular
16.
J Cardiol ; 29(4): 217-24, 1997 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9127838

RESUMO

The hemodynamic effects of acute oral administration of a newly-developed prostacyclin analogue (beraprost sodium; 1-2 micrograms/kg), inhaled nitric oxide (NO; 20 ppm) and tolazoline hydrochloride (1 mg/kg) were measured in 17 children (mean age 1 year and 9 months) with pulmonary hypertension complicating congenital heart disease or primary pulmonary hypertension. Beraprost, NO and tolazoline achieved approximately equivalent reductions in pulmonary vascular resistance (20%, 26% and 18%, p < 0.05), but the greatest percentage decrease of pulmonary to systemic resistance ratio was obtained after administration of NO (33%, p < 0.05). Furthermore, combined administration of beraprost and NO produced the maximum effect of pulmonary vasodilation without adverse effects (49%). Beraprost appears to be an effective and available substitute for NO and tolazoline in screening for pulmonary vasodilator responsiveness. The combined use of beraprost and NO may provide an alternative treatment for pulmonary hypertension in children without serious complications.


Assuntos
Epoprostenol/análogos & derivados , Hipertensão Pulmonar/tratamento farmacológico , Óxido Nítrico/administração & dosagem , Vasodilatadores/administração & dosagem , Administração por Inalação , Administração Oral , Pré-Escolar , Epoprostenol/administração & dosagem , Cardiopatias Congênitas/complicações , Humanos , Hipertensão Pulmonar/etiologia , Lactente , Circulação Pulmonar/efeitos dos fármacos , Tolazolina/uso terapêutico , Resistência Vascular/efeitos dos fármacos
17.
Pediatr Cardiol ; 16(4): 186-9, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-7567665

RESUMO

Thrombolytic therapy using tissue-type plasminogen activator was performed in a 7-month-old boy with massive mural thrombi in large coronary aneurysms due to Kawasaki disease. Magnetic resonance imaging successfully demonstrated mural thrombi in both proximal and distal coronary aneurysms and their disappearance after thrombolytic therapy. We conclude that for preventing acute myocardial infarction and sudden death intravenous and intracoronary thrombolytic therapy with tissue-type plasminogen activator may help in infants and children with Kawasaki disease who have thrombi in coronary aneurysms.


Assuntos
Aneurisma Coronário/tratamento farmacológico , Cardiopatias/tratamento farmacológico , Síndrome de Linfonodos Mucocutâneos/complicações , Ativadores de Plasminogênio/uso terapêutico , Terapia Trombolítica , Trombose/tratamento farmacológico , Ativador de Plasminogênio Tecidual/uso terapêutico , Aneurisma Coronário/complicações , Aneurisma Coronário/diagnóstico , Angiografia Coronária , Cardiopatias/complicações , Cardiopatias/diagnóstico , Humanos , Lactente , Angiografia por Ressonância Magnética , Masculino , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/prevenção & controle , Trombose/complicações , Trombose/diagnóstico
18.
Acta Paediatr Jpn ; 37(3): 336-40, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7645383

RESUMO

In order to assess bronchial responsiveness in patients with congestive heart failure secondary to congenital heart disease, we performed a histamine inhalation test while monitoring transcutaneous oxygen tension and compared the respiratory threshold to histamine with that obtained in patients with bronchial asthma. The inhalation test was performed by doubling concentrations of histamine solution for 2 min at 1 min intervals. The respiratory threshold of histamine was defined as the minimal concentration causing a drop in transcutaneous oxygen tension greater than 10% from baseline. Six of 10 patients with congenital heart disease and all of 12 patients with bronchial asthma had bronchial hyper-responsiveness to histamine. The mean of histamine concentration was 2750 micrograms/mL and 937 micrograms/mL, respectively. During the histamine inhalation test, respiratory resistance gradually increased in congenital heart disease patients. This was measured by the linear slope of transcutaneous oxygen pressure (-1.08 +/- 0.75 mmHg/min), whereas in the bronchial asthma patients it rapidly decreased at the infection point (-4.19 +/- 1.86 mmHg/min). We conclude that children with congestive heart failure had bronchial hyper-responsiveness. We suggest bronchial hyper-responsiveness to inhaled histamine in congestive heart failure was caused by the gradual increased respiratory resistance, which was different from that of bronchial asthma.


Assuntos
Hiper-Reatividade Brônquica/imunologia , Cardiopatias Congênitas/complicações , Insuficiência Cardíaca/complicações , Histamina/sangue , Monitorização Transcutânea dos Gases Sanguíneos , Hiper-Reatividade Brônquica/etiologia , Testes de Provocação Brônquica/métodos , Criança , Pré-Escolar , Feminino , Insuficiência Cardíaca/etiologia , Humanos , Lactente
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