Risk factors for prolonged ventilation after the modified Fontan procedure.

OBJECTIVE: To investigate the risk factors associated with prolonged ventilation after Fontan surgery. DESIGN: Retrospective case series. SETTING: Tertiary childrens hospital. PATIENTS: We included 123 children who underwent Fontan surgery without delayed sternal closure or extracorporeal membrane oxygenation between 2011 and 2017. INTERVENTION: Fontan surgery. MEASUREMENTS AND MAIN RESULTS: Prolonged ventilation was defined as intubation for more than 24 hours after surgery. Preoperative, intraoperative, and perioperative data were collected retrospectively from medical records. Multivariate logistic regression analysis was used to identify risk factors for prolonged ventilation. The median age and weight of patients were 2.2 years and 10.0 kg, respectively. Seventeen per cent of the patients (n = 21) received prolonged mechanical ventilation, and the median intubation period was 2.9 days. There were no 90-day or in-hospital deaths. The independent predictors of prolonged ventilation identified were fenestration (p < 0.01), low pulmonary artery index (p = 0.02), and advanced atrioventricular regurgitation (p < 0.01). The duration of ICU stay was significantly longer in the prolonged ventilation group than in the early extubation group (10 days versus 6 days, p < 0.01). CONCLUSION: Fenestration, low pulmonary artery index, and significant atrioventricular regurgitation are risk factors for prolonged ventilation after Fontan surgery. Careful preoperative and perioperative management that considers the risk factors for prolonged ventilation in each individual is important.

Pseudoaneurysm rupture presenting as bleeding from the cannulation site in a paediatric patient with dilated cardiomyopathy and congenital skin lesions requiring EXCOR® Paediatric ventricular assist device: a case report.

BACKGROUND: EXCOR® Paediatric is used worldwide as a bridge-to-transplant treatment. It provides improved patient stability during the waiting period compared with previous ventricular assist device (VAD). However, investigations into complications which may occur among the paediatric population during long waiting periods are still sparse. CASE SUMMARY: We describe the case of a 7-year-old girl who presented with severe heart failure due to dilated cardiomyopathy. She also had a skin lesion which appeared soon after birth. She had received an EXCOR® implant and was waiting for heart transplant. Her skin lesion worsened after implantation and she suffered recurrent infections. Multiple bleeding episodes from the cannulation site occurred; therefore, surgical exploration of the bleeding was performed. She passed away during the procedure due to massive bleeding caused by rupture of a pseudoaneurysm caused by blood-stream infection. DISCUSSION: Patients with skin disease may be at increased risk of infection when on a VAD. Infections that occur during VAD therapy may cause serious complications such as pseudoaneurysm. The possibility of pseudoaneurysm should be considered when bleeding occurs in a patient on VAD.

Extubation Failure in Neonates After Cardiac Surgery: Prevalence, Etiology, and Risk Factors.

BACKGROUND: The purpose of this study was to explore the prevalence, etiology, and risk factors of extubation failure (EF) in post-cardiac surgery neonates. METHODS: Neonates (30 days old or younger) who underwent cardiac surgery and were admitted to the cardiac intensive care unit between September 2010 and February 2016 were included. The prevalence and etiology of EF, defined as reintubation within 48 hours, were reviewed. Demographic, operative, and perioperative data were retrospectively collected. Multiple logistic regression models were constructed to identify the risk factors for EF. RESULTS: The median age at surgery was 10 days. Extubation failure occurred in 25 of 156 cases (16.0%; 95% confidence interval: 10.6% to 22.7%), because of respiratory dysfunction (n = 16), hemodynamic instability (n = 4), upper airway obstruction (n = 4), or gastrointestinal bleeding (n = 1). Subsequent extubations were successful in 17 cases (68%) because of medical optimization of the causes of reintubation. The remaining 8 cases needed surgical reintervention, including tracheostomy and cardiac surgery. The inhospital mortality rate was 2.6%. In a bivariate analysis, younger age, airway diseases, ventilation before surgery, prolonged mechanical ventilation, and delayed sternal closure were associated with EF. The multivariable analysis identified airway diseases (adjusted odds ratio 18.2, 95% confidence interval: 3.8 to 88.6, p = 0.0003) and mechanical ventilation longer than 7 days (adjusted odds ratio 8.2, 95% confidence interval: 1.9 to 34.9, p = 0.0046) as risk factors for EF. CONCLUSIONS: The prevalence of EF is relatively high in neonatal cardiac surgery. The etiologies can be diverse. Extubation of neonates at high risk after cardiac surgery, based on these possible risk factors, requires more diligent approaches.