1.
J Med Chem
; 46(5): 674-6, 2003 Feb 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12593646
RESUMO
Cyclosporin A is effective in the treatment of asthma patients, but its chronic use is limited by toxicity. Novel cyclosporin A analogues were synthesized utilizing the olefin metathesis reaction and evaluated in a calcineurin A inhibition assay. The novel analogues demonstrated activity comparable to activity of the parent molecule and are potential soft drugs.