RESUMO
AIMS: The aim of this study was to investigate the effect of 12 weeks of aerobic training on serum levels of high sensitivity C- reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), lipid profile and anthropometric characteristics in middle-aged women patients with type-2 diabetes. METHODS: A quasi-experimental study, 20 women patients with type-2 diabetes (mean age, 50.25⯱â¯4.36â¯years, Body mass index, 25.51⯱â¯2.91â¯kg/m2, and body fat percentage 23.67⯱â¯3.05%) were randomly categorized into two experimental and control groups. The protocol aerobic training included eight-minute jogging and eight-minute running with 75-85 percent maximum heart rate reserve in the first session. Per both sessions, one minute added to running time and it increased up to 32â¯min after 12 weeks. Blood sampling and anthropometric measurements, 24â¯h before and 48â¯h after the last training session were conducted. RESULT: The result showed a significant reduction in hs-CRP and TNF-α in the experimental than control group (Pâ¯=â¯0.01). Exercise training-treated patients showed a significant decrease in TG, LDL and increase HDL in comparison with baseline and the control group (Pâ¯<â¯.05). The results also showed a significant decrease in weight, body mass index, body fat percentage, and waist-hip ratio (P values 0.02, 0.03, 001, 0.04 respectively) following the 12 weeks aerobic training. CONCLUSION: It seems that long-term aerobic training, improved some important anthropometric and biochemical parameters in patients with type-2 diabetes. These observations give a new insight into the mechanisms by which aerobic training can reduce the cardiovascular risk in diabetes.