Mortality in infants with cardiovascular malformations.

UNLABELLED: Cardiovascular malformations are an important cause of infant death and the major cause of death due to malformation. Our aims were to analyse and categorise all deaths in infants with cardiovascular malformations, and to analyse trends in mortality over time and influences on mortality. We obtained details of infant deaths and cardiovascular malformations from the population of one health region for 1987-2006. We categorised deaths by cause and by presence of additional chromosomal or genetic abnormalities or non-cardiac malformations. In 676,927 live births the total infant mortality was 4,402 (6.5 per 1,000). A total of 4,437 infants had cardiovascular malformations (6.6 per 1000) of whom 458 (10.3%) died before 1 year of age. Of this number, 151 (33%) deaths had non-cardiac causes, 128 (28%) were cardiac without surgery and 179 (39%) occurred from cardiac causes after surgery. Death was unrelated to the cardiovascular malformation in 57% of infants with an additional chromosomal or genetic abnormality, in 76% of infants with a major non-cardiac malformation and in 16% of infants with an isolated cardiovascular malformation. Terminations of pregnancies affected by cardiovascular malformations increased from 20 per 100,000 registered births in the first 5 years to 78 per 100,000 in the last 5 years. A total of 2,067 infants (47%) underwent surgery and of these 216 (10%) died before 1 year of age. CONCLUSIONS: A total of 10.4% of infants who died had a cardiovascular malformation and two-thirds of deaths were due to the malformation or its treatment. Mortality declined due to increasing termination of pregnancy and improved survival after operation.

Accuracy of the aristotle basic complexity score for classifying the mortality and morbidity potential of congenital heart surgery operations.

BACKGROUND: The Aristotle Basic Complexity Score (ABC score) was derived by consensus of an international surgeon panel to facilitate assessment of surgical performance for quality improvement in congenital heart surgery. The utility of the ABC score depends on its ability to correctly classify procedures according to their potential for morbidity, mortality, and technical difficulty. This collaborative study combined two multiinstitution databases to assess how well the ABC score predicts the actual morbidity and mortality potential of 131 congenital heart surgery procedures. METHODS: Data from the European Association of Cardiothoracic Surgery (EACTS) congenital database (17,838 operations, 56 centers) and the Society of Thoracic Surgeons (STS) congenital database (18,024 operations, 32 centers) were analyzed. Discrimination of the ABC score for predicting in-hospital mortality and postoperative length of stay (PLOS) of more than 21 days was quantified by the C statistic. Procedure-specific rates of mortality and prolonged PLOS were compared with predictions from a logistic regression model, and an exact binomial test was used to identify procedures that were mortality and morbidity outliers. RESULTS: There was a significant positive correlation between the ABC score of a procedure and its observed procedure-specific risk of mortality (C = 0.70) and prolonged PLOS (C = 0.67). Several individual procedures were identifed as mortality and morbidity outliers. CONCLUSIONS: The ABC score generally discriminates between low-risk and high-risk congenital procedures making it a potentially useful covariate for case-mix adjustment in congenital heart surgery outcomes analysis. Planned revisions of the ABC score will incorporate empirical data and will benefit from the large sample sizes of the STS and EACTS databases.

Effects of 'Bristol' on surgical practice in the United Kingdom.

In 1995 a child died following an arterial switch operation for complex transposition of the great arteries. There had been general concern regarding the outcomes for the arterial switch procedure in the unit in Bristol. A review, prompted by parents whose children had died, showed that 29 children had died and four others suffered from cerebral damage postoperatively. The General Medical Council (GMC) considered the conduct of three doctors from the unit. This hearing culminated in the suspension and subsequent removal from the Medical Register of the senior Cardiac Surgeon and the Chief Executive of the hospital. The second Cardiac Surgeon was banned from practising in the field of paediatric cardiac surgery for three years (his results in adult cardiac surgical practice were not called into question). Following this the Government set up a public Inquiry to investigate the causes behind the deaths. This Inquiry, which took three years, made recommendations that have affected the way all doctors in the UK practice.