1.
Org Lett
; 10(5): 917-20, 2008 Mar 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18225911
RESUMO
Aryl-bridged C1-symmetric oxazolinyl sulfoximines are applicable in copper-catalyzed asymmetric Mukaiyama aldol reactions with methyl pyruvate. The resulting alpha-hydroxy esters have been obtained with up to 94% ee in good yields. They contain a quaternary stereogenic center and represent valuable precursors for biologically active molecules.