RESUMO
Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases.
RESUMO
OBJECTIVE: To evaluate the application value of multiple phase subtraction imaging of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in common breast tumor. METHODS: All radiographic and MRI data of 72 patients with histological proved common breast tumor were analyzed retrospectively. Prior to an injection of gadolinium-diethylenetriaminepentaacetate (GD-DTPA), 3D mask scans were performed. Then 9 consecutive phases of imaging were acquired. After the drawing of time-signal intensity curve, he first and second phases were selected to perform subtraction with the mask, rebuild 3D maximum intensity projection and analyze the application value of subtracted and 3D maximum intensity projection (MIP) reformation images. Chi-square test was used for the analyses of benign and malignant breast tumors. RESULTS: There were 83 lesions in 72 patients. Among 18 cases of fibro adenoma, 23 lesions had no tumor vessel. For the detecting ratio of lesions, the first and second phase subtraction imaging had no statistics difference. Only one intraductal papilloma with ductal carcinoma in situ (DCIS) had tumor vessel in 4 intraductal papilloma patients. Among 5 DCIS cases, one of them had small curved tumor vessel. And 51 lesions were found in 45 infiltrating ductal carcinoma (IDC) cases. Tumor vessels could be seen in all IDC cases. And 37 cases had multiple tumor vessels while 8 cases had single tumor vessel. When the first phase was used for subtraction, 36 lesions were found. On the other hand, 51 lesions were found in the second phase subtraction. There were significant differences between them. CONCLUSION: No significant differences exist in benign breast tumor on differential phase subtraction images of DCE-MRI, but there are significant differences in malignant breast tumor. It is very important to detect the lesions and show the tumor vessels by rebuilding multiple phase subtraction.
