1.
Org Lett
; 12(19): 4240-3, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20828188
RESUMO
α-Amino imides can be accessed straightforwardly from tertiary amines through copper-catalyzed three-component reactions involving the direct functionalization of sp(3) C-Hs adjacent to nitrogen atoms. This reaction has demonstrated a tolerance to a wide range of functionalizations and can be performed under very mild conditions. A plausible mechanism has been proposed in which an Ugi-type cascade assembly has been included.