Collision carcinoma of endometrial adenocarcinoma and primary serous fallopian tube carcinoma: a case report.

Collision carcinoma is a rare malignancy that generally occurs in cervical, esophageal, pulmonary, and squamous cell cancers. Few studies have been reported involving endometrial adenocarcinoma and fallopian tube carcinoma. We reported the case of a 58-year-old woman who presented because of irregular vaginal bleeding for more than 1 month. Cervical biopsy suggested moderately differentiated cervical adenocarcinoma, and the patient underwent radical hysterectomy under general anesthesia. However, postoperative pathology and immunohistochemical results indicated a collision tumor comprising endometrial adenocarcinoma (grade I) and primary serous fallopian tube carcinoma. According to the treatment principle of multiple primary tumors, a regimen of paclitaxel combined with carboplatin was administered. The patient also underwent local pelvic radiotherapy to treat lymph node metastasis. One month later, the patient developed brain metastases and died.

ß-cyclodextrin functionalized biochars as novel sorbents for high-performance of Pb2+ removal.

The aim of this study was to synthesize the functionalized biochars with ß-cyclodextrin (ß-CD), compare the two kinds of adsorption capability, and try to explore the possible mechanism for the adsorption Pb2+ by ß-CD functionalized rice straw and palm biochars in the aquatic environment. The performance of the functionalized biochars was matched against the activated and raw biochars. Rice straw biochar loaded with ß-CD performed better than functionalized palm biochar with the adsorption capabilities of 130.60 mg/g and 90.30 mg/g at Pb2+ concentration of 3000 mg/L and 2000 mg/L, respectively. Maximum adsorption capability of functionalized rice straw and palm biochars from the Langmuir isotherms were all fitted out to be 131.24 mg/g and 118.08 mg/g for Pb2+. Kinetics and thermodynamics are combined to investigate the Pb2+ removal by the two functionalized biochars, e.g, Pb2+ is mainly removed by chemical process for functionalized palm biochar, whereas by both physical and chemical factors for functionalized rice straw biochar.

Secreted frizzled-related protein 1 (SFRP1) gene methylation changes in the human lung adenocarcinoma cells treated with L-securinine.

Lung cancer remains the leading cause of cancer-related death worldwide. It is important to explore the biomarkers of diagnosis and prognosis in lung cancer. To evaluate the cytotoxicity of L-securinine and the expression and methylation of secreted frizzled-related proteins (SFRPs) genes in the human lung adenocarcinoma cells, cell counting kit-8 (CCK-8) assay was used to assess the proliferation of lung adenocarcinoma cells treated with L-securinine. Quantitative real-time PCR (qRT-PCR) and bisulfite sequencing PCR were used to detect the expression and the DNA methylation of SFRPs genes, respectively. L-securinine inhibited the proliferation of lung adenocarcinoma cells and induced the upregulation of SFRP1 gene expression and the methylation changes at CpG sites in the SFRP1 promoter region. L-securinine was a potential agent in the treatment of lung cancer by upregulation of SFRP1 gene expression and changing the SFRP1 gene methylation.