RESUMO
Abstract Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. The pustules resolved within about two weeks after the patient discontinued the antibiotics. This report discusses the case of a woman with a cutaneous drug reaction consistent with acute localized exanthematous pustulosis that occurred after cefoperazone and sodium sulbactam were administered.
Assuntos
Humanos , Feminino , Idoso , Sulbactam/efeitos adversos , Cefoperazona/efeitos adversos , Pustulose Exantematosa Aguda Generalizada/etiologia , Pustulose Exantematosa Aguda Generalizada/patologia , Antibacterianos/efeitos adversos , Pele/patologia , Fatores de Tempo , BiópsiaRESUMO
Abstract Onychogryphosis is an acquired nail plate change. It often affects the toenail and is characterized by an opaque, yellow-brownish nail plate that is distorted, grossly thickened, elongated, and partly curved resembling a ram's horn. Tuberous sclerosis complex is a multisystem disorder associated with high rates of mental retardation, autism, cognitive impairment, behavioral problems, or seizures. Nail disease can also be associated, which is a concern to patients due to pain and nail distortion. We reported a typical tuberous sclerosis complex patient with distinctive clinical features of a ram's horn nails, which presented a great challenge to surgical treatment and nail restoration.
Assuntos
Humanos , Feminino , Idoso , Esclerose Tuberosa/patologia , Doenças da Unha/patologia , Esclerose Tuberosa/diagnóstico por imagem , Encéfalo/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Angiofibroma/patologia , Angiofibroma/diagnóstico por imagem , Neoplasias Renais/diagnóstico por imagem , Lipoma/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Unhas/patologiaAssuntos
Hamartoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Bochecha , Pré-Escolar , Diagnóstico Diferencial , Feminino , Folículo Piloso/patologia , Hamartoma/congênito , Hamartoma/patologia , Humanos , Glândulas Sebáceas/patologia , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/patologiaRESUMO
Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. The pustules resolved within about two weeks after the patient discontinued the antibiotics. This report discusses the case of a woman with a cutaneous drug reaction consistent with acute localized exanthematous pustulosis that occurred after cefoperazone and sodium sulbactam were administered.
Assuntos
Pustulose Exantematosa Aguda Generalizada/etiologia , Pustulose Exantematosa Aguda Generalizada/patologia , Antibacterianos/efeitos adversos , Cefoperazona/efeitos adversos , Sulbactam/efeitos adversos , Idoso , Biópsia , Feminino , Humanos , Pele/patologia , Fatores de TempoRESUMO
Onychogryphosis is an acquired nail plate change. It often affects the toenail and is characterized by an opaque, yellow-brownish nail plate that is distorted, grossly thickened, elongated, and partly curved resembling a ram's horn. Tuberous sclerosis complex is a multisystem disorder associated with high rates of mental retardation, autism, cognitive impairment, behavioral problems, or seizures. Nail disease can also be associated, which is a concern to patients due to pain and nail distortion. We reported a typical tuberous sclerosis complex patient with distinctive clinical features of a ram's horn nails, which presented a great challenge to surgical treatment and nail restoration.
Assuntos
Doenças da Unha/patologia , Esclerose Tuberosa/patologia , Idoso , Angiofibroma/diagnóstico por imagem , Angiofibroma/patologia , Encéfalo/diagnóstico por imagem , Feminino , Humanos , Neoplasias Renais/diagnóstico por imagem , Lipoma/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Unhas/patologia , Tomografia Computadorizada por Raios X , Esclerose Tuberosa/diagnóstico por imagemRESUMO
Dendritic myxofibrolipoma is a newly described benign soft tissue tumor that could be easily mistaken for sarcoma. It develops primarily in the subcutis or muscular fascia of the head and neck, shoulders, etc. Histologically, the tumor is characterized by an admixture of mature adipose tissue, spindle and stellate cells, and abundant myxoid stroma with prominent collagenization. These neoplasms typically show positive immunoreactivity for CD-34, vimentin and Bcl-2. Herein, we described a rare case presenting with a papule on the nasal tip in a 69-year old patient. Histopathology and immunohistochemical staining confirmed the diagnosis. In short, it brings the attention of clinicians to the importance of proper identification and characterization of this tumor.
Assuntos
Fibroma/patologia , Lipoma/patologia , Neoplasias Nasais/patologia , Idoso , Biomarcadores Tumorais/análise , Biópsia , Diagnóstico Diferencial , Fibroma/química , Fibroma/cirurgia , Humanos , Imuno-Histoquímica , Lipoma/química , Lipoma/cirurgia , Masculino , Neoplasias Nasais/química , Neoplasias Nasais/cirurgia , Valor Preditivo dos TestesRESUMO
Favre-Racouchot syndrome (FRS) is a disorder consisting of solar elastosis with the presence of multiple cysts and open comedones. Although the exact mechanism of the condition is not known, FRS has been specifically connected to sun exposure, smoking and radiation exposure. The histological changes present in FRS reveal an atrophic epidermis and large masses of keratinous material, causing follicular plugging, as well as solar elastotic changes and possible basophilic degeneration of connective tissue. Herein, we report an unusual case of FRS concurrent with chronic granulomatous reaction and review relevant published works.
Assuntos
Dermatoses Faciais/complicações , Doença Granulomatosa Crônica/complicações , Idoso , Diagnóstico Diferencial , Dermatoses Faciais/patologia , Doença Granulomatosa Crônica/patologia , Humanos , MasculinoRESUMO
Hemangioblastoma is a rare neoplasm occurred in soft tissue. Herein, we present an intriguing case of sporadic hemangioblastoma in the retroperitoneum occurring in a 59-year-old male. The tumor was characterized by an alternation of cellular and paucicellular areas surrounded by a thick fibrous capsule. The stromal cells showed a pale cytoplasm exhibiting occasional lipid droplets and hyperchromatic, irregularly nuclei. CD56, NSE, a-inhibin and S100 were positive in tumor cells. This is the third reported case of a hemangioblastoma in the retroperitoneum. Based on clinical examination, computed tomography imaging, surgical operation, and histopathologic studies, a definitive diagnosis was made. Further characteristic images and pathology of this disease are discussed.
Assuntos
Hemangioblastoma/diagnóstico , Neoplasias Retroperitoneais/diagnóstico , Antígeno CD56/metabolismo , Hemangioblastoma/patologia , Hemangioblastoma/cirurgia , Humanos , Inibinas/metabolismo , Masculino , Pessoa de Meia-Idade , Neoplasias Retroperitoneais/patologia , Neoplasias Retroperitoneais/cirurgia , Proteínas S100/metabolismo , Tomografia Computadorizada por Raios X , Resultado do TratamentoAssuntos
Hemangioendotelioma/patologia , Neoplasias Cutâneas/patologia , Idoso , Feminino , Pé/patologia , HumanosRESUMO
Xanthogranulomatous cystitis is a rare, benign chronic inflammatory disorder with unclear etiology. Since its similar features to bladder neoplasm, it is extremely easy to be mistaken for malignant tumor. We herein reported a case of xanthogranulomatous cystitis in a 54-year-old male who presented with low abdominal pain and painless, total macrohematuria. Microscopy showed proliferation of large foam histiocytes which expressed CD68 and vimentin. Ki-67 showed a lower proliferation index (< 10%). Histopathology and immunohistochemical findings confirmed the diagnosis. This case highlighted the significance of recognizing this unusual lesion and differentiating it from its histological mimics by immunohistochemical staining.
Assuntos
Cistite/diagnóstico , Neoplasias da Bexiga Urinária/diagnóstico , Biomarcadores Tumorais/análise , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-IdadeRESUMO
Tuberous sclerosis is a genetic multisystem disorder characterized by widespread hamartomas in several organs. Clinically, more than 90% of affected patients have skin lesions including facial angiofibromas, periungual fibromas, hypomelanotic macule, etc. Periungual fibroma is one of the major diagnostic criteria of tuberous sclerosis and has the same pathology (angiofibroma) as the facial papules. We herein describe an interesting histologic variant of angiofibromas coupled with multiple epidermoid cysts in a 33-year-old patient with tuberous sclerosis.