RESUMO
The AuCu3-type intermetallic compoundsReIn3(Re= a rare earth ion) with type-IV magnetic space groups are predicted to show topologically nontrivial electronic states. Here, we grow ErIn3single crystals, and study their magnetic properties and critical behaviors by means of the magnetic susceptibility, and magnetization isotherm measurements. Combining a detailed analysis of the magnetic susceptibility and isothermal magnetization, we find that this compound harbors a complicated magnetic phase diagram, and its magnetic moment arrangement appears not to simply follow the fashion as observed in the isostructural counterpart GdIn3(it adopts a conventional type-Cmagnetic structure that belongs to type-IV magnetic space groups). A careful study of the magnetic properties around the antiferromagnetic (AFM)-paramagnetic transition yields the critical exponentsß= 0.309 (0.297),γ= 1.117 (1.038), andδ= 4.617 (4.454), indicating that the tricritical mean field model or the three-dimensional Ising model works for ErIn3's magnetic behaviors and the presence of a long-range AFM interaction therein. Besides, the exchange interaction distanceJ(r) â¼r-4.665as well confirms a long-range magnetic coupling in ErIn3. Our results offer the clues that the magnetic structure varies from one member ofReIn3family to another, and to confirm their electronic features in the AFM phases further experimental and theoretical studies are still desired.
RESUMO
PrBi, a sister member of the rare-earth monopnictide family, is an excellent candidate for studying extreme magnetoresistance and nontrivial topological electronic states. In this study, we perform angular magnetoresistance measurements as well as bulk and surface band structure calculations on this compound. PrBi's magnetoresistance is revealed to be significantly angle-dependent and shows a fourfold symmetry as always observed in the nonmagnetic isostructural counterparts, including LaSb, LaBi, and LuBi. Its angular magnetoresistance can be reproduced well using the semiclassical two-band model. The deduced parameters suggest that PrBi hosts an elongated electron pocket with a mobility anisotropy of â¼3.13 and is slightly uncompensated in its carrier concentration. Our bulk and surface band structure calculations confirm the anisotropic electronic features. Moreover, we reveal that a nodal-line-shaped surface state appears at the XÌ point, and is associated with the quadratic dispersion along the îº-XÌ direction, and the linear type-I Dirac dispersion along the XÌ-MÌ direction. Owing to the type-I Dirac dispersion feature, PrBi could serve as a promising material platform for studying many unexpected physical properties, such as the highly anisotropic transport and valley polarization of electrons.
RESUMO
Iron chalcogenides are of particular interests among iron-based superconductors due to their distinct properties such as high-Tcon FeSe monolayer and competing magnetic correlations in Fe1+yTe. Here we report unusual transport properties observed near the critical composition of Fe1+yTe (yâ¼ 0.09) where competing magnetic correlations exist. The resistivity exhibits surprising temperature-dependent relaxation behavior belowTN, resulting in the increase of resistivity with time for 35 K
RESUMO
HLA-A*02:625 differs from HLA-A*02:06:01:01 by a single nucleotide substitution at position 806 C>T.
RESUMO
HLA-B*40:333 differs from HLA-B*40:01:01 by a single nucleotide substitution at position 380 T>C.
Assuntos
Alelos , Antígenos HLA-B/genética , Teste de Histocompatibilidade/métodos , Reação em Cadeia da Polimerase/métodos , Sequência de Bases , Éxons/genética , Loci Gênicos , Humanos , Alinhamento de SequênciaRESUMO
HLA-B*27:04:06 differs from HLA-B*27:04:01 by a single-nucleotide substitution at position 396 C > A.
Assuntos
Alelos , Povo Asiático/genética , Medula Óssea/metabolismo , Antígenos HLA-B/genética , Doadores de Tecidos , Sequência de Bases , Éxons/genética , HumanosRESUMO
HLA-DQB1*03:181 has one nucleotide change from HLA-DQB1*03:05:01 at position 470C>G.
Assuntos
Alelos , Povo Asiático/genética , Cadeias beta de HLA-DQ/genética , Leucemia/genética , Sequência de Bases , Éxons/genética , HumanosRESUMO
HLA-DRB1*15:127 has 1 nucleotide change from HLA-DRB1*15:01:01:01 at position 308 C>G.
Assuntos
Alelos , Medula Óssea , Técnicas de Genotipagem , Cadeias HLA-DRB1/genética , Reação em Cadeia da Polimerase , Doadores de Tecidos , China , HumanosRESUMO
HLA-B*27:147 differs from HLA-B*27:04:01 by a single nucleotide substitution at position 523 C>G.
Assuntos
Alelos , Técnicas de Genotipagem/métodos , Antígeno HLA-B27/genética , Reação em Cadeia da Polimerase/métodos , HumanosRESUMO
HLA-B*52:01:27 differs from HLA-B*52:01:01 by a single nucleotide substitution at position 681 C>T.
Assuntos
Alelos , Éxons , Antígeno HLA-B52/genética , Polimorfismo de Nucleotídeo Único , Povo Asiático , Sequência de Bases , Códon/química , Expressão Gênica , Genótipo , Antígeno HLA-B52/imunologia , Transplante de Células-Tronco Hematopoéticas , Teste de Histocompatibilidade , Humanos , Reação em Cadeia da Polimerase , Alinhamento de Sequência , Análise de Sequência de DNA , Doadores de TecidosRESUMO
HLA-B*55:02:09 and HLA-B*55:80 differ from HLA-B*55:02:01 by 1 single nucleotide substitution, respectively.
Assuntos
Alelos , Éxons , Antígenos HLA-B/genética , Polimorfismo de Nucleotídeo Único , Doadores de Tecidos , Substituição de Aminoácidos , Povo Asiático , Sequência de Bases , Transplante de Medula Óssea , Códon/química , Expressão Gênica , Genótipo , Antígenos HLA-B/imunologia , Teste de Histocompatibilidade , Humanos , Reação em Cadeia da Polimerase , Isoformas de Proteínas/genética , Isoformas de Proteínas/imunologia , Alinhamento de Sequência , Análise de Sequência de DNARESUMO
HLA-B*13:83 differs from HLA-B*13:01:01 by 2 nucleotide substitutions at positions 103 and 106.
Assuntos
Alelos , Doadores de Sangue , Éxons , Antígeno HLA-B13/genética , Polimorfismo de Nucleotídeo Único , Substituição de Aminoácidos , Povo Asiático , Sequência de Bases , Códon/química , Transplante de Células-Tronco de Sangue do Cordão Umbilical , Expressão Gênica , Genótipo , Antígeno HLA-B13/imunologia , Teste de Histocompatibilidade , Humanos , Reação em Cadeia da Polimerase , Alinhamento de Sequência , Análise de Sequência de DNARESUMO
HLA-C*08:128 shows a substitution C to T at position 704 when compared to HLA-C*08:01:01.
Assuntos
Alelos , Éxons , Antígenos HLA-C/genética , Polimorfismo de Nucleotídeo Único , Transplantados , Substituição de Aminoácidos , Povo Asiático , Sequência de Bases , Códon/química , Expressão Gênica , Genótipo , Antígenos HLA-C/imunologia , Transplante de Células-Tronco Hematopoéticas , Teste de Histocompatibilidade , Humanos , Leucemia/genética , Leucemia/imunologia , Leucemia/patologia , Leucemia/terapia , Reação em Cadeia da Polimerase , Alinhamento de Sequência , Análise de Sequência de DNARESUMO
HLA-C*01:109N differs from HLA-C*01:02:01 by a single nucleotide substitution at position 683 G > A.
Assuntos
Alelos , Códon sem Sentido , Éxons , Antígenos HLA-C/genética , Leucemia/genética , Transplantados , Povo Asiático , Sequência de Bases , Transplante de Medula Óssea , Clonagem Molecular , Expressão Gênica , Genótipo , Antígenos HLA-C/imunologia , Teste de Histocompatibilidade , Humanos , Leucemia/imunologia , Leucemia/patologia , Leucemia/terapia , Reação em Cadeia da Polimerase , Alinhamento de Sequência , Análise de Sequência de DNARESUMO
HLA-DRB1*08:69 has one nucleotide change from HLA-DRB1*08:03:02 at position 262 G>A.
RESUMO
In this work, we studied the phase transitions and exchange bias of Ni50-xMn36Sn14Tx (T = Pd, Pt; x = 0, 1, 2, 3) alloys. An intermartensitic transition (IMT), not observed in Ni50Mn36Sn14 alloy, was induced by the proper application of negative chemical pressure by Pd(Pt) doping in Ni50-xMn36Sn14Tx (T = Pd, Pt) alloys. IMT weakened and was suppressed with the increase of applied field; it also disappeared with further increase of Pd(Pt) content (x = 3 for Pd and x = 2 for Pt). Another striking result is that exchange bias effect, ascribed to the percolating ferromagnetic domains coexisting with spin glass phase, is notably enhanced by nonmagnetic Pd(Pt) addition. The increase of unidirectional anisotropy by the addition of Pd(Pt) impurities with strong spin-orbit coupling was explained by Dzyaloshinsky-Moriya interactions in spin glass phase.
RESUMO
HLA-B*54:34 is different from HLA-A*54:01:01 by a single nucleotide substitution at position 343 G>A.
Assuntos
Alelos , Éxons , Antígenos HLA-B/genética , Leucemia/genética , Mutação Puntual , Substituição de Aminoácidos , Povo Asiático , Sequência de Bases , Transplante de Medula Óssea , Códon , Feminino , Genótipo , Antígenos HLA-B/imunologia , Teste de Histocompatibilidade , Humanos , Leucemia/imunologia , Leucemia/patologia , Masculino , Herança Materna , Mães , Alinhamento de Sequência , Análise de Sequência de DNA , IrmãosRESUMO
PURPOSE: ZFP36 ring finger protein (ZFP36) and the suppressor of cytokine signaling 3 (SOCS3) have been reported to, respectively, regulate NF-κB and STAT3 signaling pathways. To better understand the correlation of NF-κB and STAT3 negative regulates pathway, we have investigated the involvement of ZFP36 and SOCS3 expressions in human prostate cancer (PCa). METHODS: In the present study, paired patient tissue microarrays were analyzed by immunohistochemistry, and the ZFP36 protein expression was quantitated as immunoreactive scores in patients with PCa. Associations between ZFP36/SOCS3 expression and various clinicopathological features and prognosis of PCa patients were statistically analyzed based on the Taylor database. Then, the functions of ZFP36 and SOCS3 in cancerous inflammation were determined using qPCR and immunohistochemistry in vitro and in vivo. RESULTS: ZFP36 protein expression in PCa tissues was significantly lower than those in non-cancerous prostate tissues (P < 0.05). In mRNA level, ZFP36 and SOCS3 had a close correlation with each other (P < 0.01, Pearson r = 0.848), and its upregulation was both significantly associated with low Gleason score (P < 0.001 and P < 0.001, respectively), negative metastasis (P < 0.001 and P < 0.001, respectively), favorable overall survival (P < 0.001 and P < 0.05, respectively), and negative biochemical recurrence (P < 0.001 and P < 0.001, respectively). Functionally, LPS treatment could lead to the overexpression of ZFP36 and SOCS3 in vitro and vivo. CONCLUSIONS: Our data offer the convincing evidence for the first time that the aberrant expressions of ZFP36 and SOCS3 may be involved into the progression and patients' prognosis of PCa, implying their potentials as candidate markers of this cancer.
Assuntos
Biomarcadores Tumorais/análise , Neoplasias da Próstata/patologia , Proteína 3 Supressora da Sinalização de Citocinas/biossíntese , Tristetraprolina/biossíntese , Idoso , Idoso de 80 Anos ou mais , Animais , Intervalo Livre de Doença , Humanos , Imuno-Histoquímica , Inflamação/metabolismo , Inflamação/patologia , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Prognóstico , Modelos de Riscos Proporcionais , Neoplasias da Próstata/metabolismo , Neoplasias da Próstata/mortalidade , Ratos , Ratos Sprague-Dawley , Proteína 3 Supressora da Sinalização de Citocinas/análise , Análise Serial de Tecidos , Tristetraprolina/análiseRESUMO
In this work, a self-powered photodetector device is fabricated through the integration of a palladium-doped molybdenum disulfide thin film on silicon (Pd-MoS2/Si). The substitution of host Mo atoms with Pd dopants in the MoS2 film is revealed by structural and chemical analysis techniques. Due to the incorporation of Pd atoms into the MoS2 films, the photovoltaic characteristics of the fabricated Pd-MoS2/Si device were enhanced largely, promoting its application as a self-powered photodetector operated at zero bias voltage. The obtained results further show that the device is highly sensitive to broadband wavelengths from ultraviolet to near-infrared light (300-1100 nm). In particular, the Pd-MoS2/Si photodetector shows an ultra-high detectivity of â¼10(14) Jones (Jones = cm Hz(1/2) W(-1)), a responsivity of â¼654.0 mA W(-1), and an ultrafast response speed of â¼2.1 µs. The present work opens new avenues for developing high-performance photodetectors for optical communications and imaging techniques as well as optoelectronic circuits.
RESUMO
Compared with HLA-DQB1*03:03:02:01, HLA-DQB1*03:03:08 and DQB1*03:03:13 have 330 G>C and 349 T>C changes, respectively.