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1.
Adv Ther ; 38(3): 1425-1446, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33570737

RESUMO

While radiation therapy is increasingly utilized in the treatment paradigm of many solid cancers, the chronic effects of radiation therapies are poorly characterized. Notably, understanding radiation-specific chronic pain syndromes is paramount given that the diagnosis and management of these conditions can serve to prevent long-standing functional impairments, optimize quality of life, and even allow for continued radiotherapy candidacy. These radiation-specific chronic pain phenomena include dermatitis, mucositis, enteritis, connective tissue fibrosis, lymphedema, and neuropathic pain syndromes. It is necessary to maintain a low threshold of suspicion for appropriately diagnosing these conditions as there exists a variance in when these symptoms arise after radiation. However, we present key epidemiological data delineating vulnerable cancer populations for each pain syndrome along with the available evidence for the management for each specific condition.


Assuntos
Dor Crônica , Neoplasias , Neuralgia , Dor Crônica/epidemiologia , Dor Crônica/etiologia , Humanos , Neoplasias/complicações , Neoplasias/radioterapia , Qualidade de Vida , Síndrome
2.
Diagn Microbiol Infect Dis ; 76(2): 158-61, 2013 06.
Artigo em Inglês | MEDLINE | ID: mdl-23578976

RESUMO

Procalcitonin (PCT) and pro-adrenomedullin (ProADM) have been proposed as diagnostic and prognostic biomarkers of infection. Between July 2009 and January 2012, we studied the role of these biomarkers in 163 patients with clustered gram-positive and gram-negative bacteremia. PCT levels were significantly higher in patients with Staphylococcus aureus and gram-negative bacteremia than those with coagulase-negative staphylococci (CoNS) isolated from blood cultures (P = 0.29 and <0.001, respectively). ProADM levels were only significantly higher in patients with gram-negative bacteremia (median 1.46 nmol/L) than those with CoNS (median 1.01 nmol/L) (P = 0.04). Among patients with CoNS, PCT, and ProADM, levels failed to differentiate blood contamination (medians 0.24 ng/mL and 0.97 nmol/L) from true bacteremia (medians 0.26 ng/mL and 1.14 nmol/L) (P = 0.51 and 0.57, respectively). In cancer patients, PCT (and to a lesser extent, ProADM) was useful in differentiating CoNS from S. aureus and gram-negative bacteremia.


Assuntos
Adrenomedulina/sangue , Calcitonina/sangue , Precursores de Proteínas/sangue , Infecções Estafilocócicas/diagnóstico , Staphylococcus aureus/classificação , Staphylococcus/classificação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Bacteriemia/diagnóstico , Biomarcadores/sangue , Peptídeo Relacionado com Gene de Calcitonina , Criança , Pré-Escolar , Humanos , Lactente , Pessoa de Meia-Idade , Estudos Retrospectivos , Infecções Estafilocócicas/microbiologia , Staphylococcus/isolamento & purificação , Staphylococcus aureus/isolamento & purificação , Adulto Jovem
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