1.
Org Lett
; 24(3): 809-814, 2022 Jan 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35048709
RESUMO
CO2 fixation into electron-deficient aromatic C-H bonds proceeds with the combined Brønsted bases LiO-t-Bu and LiO-t-Am/CsF/18-crown-6 (t-Am = CEtMe2) under a CO2 atmosphere to afford a variety of polyfunctionalized aromatic carboxylic acids.
2.
Chemistry
; 25(13): 3235-3239, 2019 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30637844
RESUMO
We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C-H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert-butyl carbonate species.