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Behav Neurosci ; 105(6): 901-12, 1991 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-1663761

RESUMO

Using a 2-lever choice paradigm with concurrent variable interval schedules of reward, it was found that when pulse frequency is increased, the preference-determining rewarding effect of 0.5-s trains of brief cathodal pulses delivered to the medial forebrain bundle of the rat saturates (stops increasing) at values ranging from 200 to 631 pulses/s (pps). Raising the current lowered the saturation frequency, which confirms earlier, more extensive findings showing that the rewarding effect of short trains saturates at pulse frequencies that vary from less than 100 pps to more than 800 pps, depending on the current. It was also found that the maximum possible reward--the magnitude of the reward at or beyond the saturation pulse frequency--increases with increasing current. Thus, increasing the current reduces the saturation frequency but increases the subjective magnitude of the maximum possible reward.


Assuntos
Estimulação Elétrica/métodos , Feixe Prosencefálico Mediano/fisiologia , Motivação , Autoestimulação/fisiologia , Transmissão Sináptica/fisiologia , Animais , Comportamento Apetitivo/fisiologia , Axônios/fisiologia , Mapeamento Encefálico , Masculino , Atividade Motora/fisiologia , Neurônios/fisiologia , Ratos , Ratos Endogâmicos
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