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1.
Br J Oral Maxillofac Surg ; 55(8): 809-814, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28807482

RESUMO

To understand and reduce the impact of postoperative complications, we studied 568 patients who had had operations over 72 months in our hospital. Multivariate analysis indicated that factors indicative of coexisting conditions (including activated systemic inflammation) and the complexity of the operation are primary determinants of postoperative complications. The enhanced recovery after surgery (ERAS) care pathway did not have an effect on their occurrence or severity. Systematic study of patients' toleration of major head and neck operations is required, as optimal perioperative care pathways remain elusive.


Assuntos
Retalhos de Tecido Biológico , Neoplasias de Cabeça e Pescoço/cirurgia , Complicações Pós-Operatórias/epidemiologia , Humanos , Estudos Prospectivos
4.
J Oral Pathol Med ; 35(8): 508-12, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16918603

RESUMO

Dyskeratosis congenita is an inherited disorder that usually presents in males, consisting of a triad of leukoplakia of the mucous membranes, nail dystrophy and skin pigmentation. Whilst most cases are X-linked, autosomal dominant and recessive forms have also been reported. The significance of the condition lies in premature mortality arising from either bone marrow failure or malignant change within the areas of mucosal leukoplakia. We present a case (X-linked recessive form) where the classic triad of signs were present, along with the development of lichenoid reaction in the buccal and labial mucosa. This is believed to be the first case in which such a reaction has been noted together with the oral hyperkeratosis. The identification of a white patch within the mouth of a child, in the absence of any other obvious cause must arouse suspicion of this rare condition. All clinicians should be aware of this rare genetic disorder so that early referral can be made and appropriate management instigated.


Assuntos
Disceratose Congênita/diagnóstico , Adolescente , Carcinoma de Células Escamosas/patologia , Criança , Diagnóstico Diferencial , Disceratose Congênita/terapia , Evolução Fatal , Humanos , Leucoplasia Oral/diagnóstico , Líquen Plano Bucal/diagnóstico , Masculino , Neoplasias da Língua/patologia
5.
Oral Oncol ; 42(4): 331-6, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16140563

RESUMO

Dyskeratosis congenita is an inherited disorder that usually presents in males, consisting of the triad of leukoplakia of the mucous membranes, nail dystrophy and skin pigmentation. Whilst most cases are X-linked, autosomal dominant and recessive forms have been reported. The significance of the condition lies in premature mortality arising from either bone marrow failure or malignant change within the areas of leukoplakia. Various mucocutaneous and non-mucocutaneous manifestations have been reported. The syndrome arises from an inherited defect within the DKC1 gene that codes for the protein dyskerin in the X-linked recessive form of the disorder, whereas mutations in the RNA component of telomerase (TERC) result in the autosomal dominant form of the condition. The identification of a white patch within the mouth of a child in the absence of any other obvious cause should arouse suspicion of this rare condition. Greater understanding of the molecular biology surrounding this syndrome should lead to improvements in diagnosis, monitoring of disease progression and therapy.


Assuntos
Proteínas de Ciclo Celular/genética , Disceratose Congênita/genética , Proteínas Nucleares/genética , Disceratose Congênita/classificação , Disceratose Congênita/patologia , Feminino , Humanos , Masculino , Telomerase/genética
6.
Br J Oral Maxillofac Surg ; 43(2): 188-9, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15749226

RESUMO

We describe a simple and cost effective technique for the insertion of calverial bone grafts for augmentation rhinoplasty.


Assuntos
Transplante Ósseo/métodos , Rinoplastia/métodos , Humanos , Crânio/cirurgia
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