1.
Prog Brain Res
; 106: 259-68, 1995.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8584662
Assuntos
Proteínas de Ligação ao GTP/metabolismo , Receptores de Amina Biogênica/metabolismo , Sistemas do Segundo Mensageiro/fisiologia , Sequência de Aminoácidos , Epinefrina/farmacologia , Dados de Sequência Molecular , Estrutura Molecular , Octopamina/farmacologia , Receptores de Amina Biogênica/genética
2.
EMBO J
; 13(6): 1325-30, 1994 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8137817
RESUMO
A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy.